A5103002102- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Diseases and Glomerulopathies
- Brain Metastases and Treatment
- Platelet Disorders and Treatments
- Gut microbiota and health
- interferon and immune responses
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cell Adhesion Molecules Research
- Clostridium difficile and Clostridium perfringens research
- Eosinophilic Disorders and Syndromes
- Knowledge Management and Technology
- Vasculitis and related conditions
- Salivary Gland Disorders and Functions
- Skin Diseases and Diabetes
- Renal cell carcinoma treatment
- Traffic Prediction and Management Techniques
- Renal and related cancers
- Fire Detection and Safety Systems
- Radiopharmaceutical Chemistry and Applications
- Inflammasome and immune disorders
- Liver Diseases and Immunity
- Sphingolipid Metabolism and Signaling
First Affiliated Hospital Zhejiang University
2019-2025
Peking Union Medical College Hospital
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Xiamen University
2009-2025
Heilongjiang Provincial Academy of Agricultural Sciences
2025
Zhejiang University
2021-2024
Ministry of Education of the People's Republic of China
2021
University of Michigan–Ann Arbor
2021
Kaohsiung Medical University
2006
Background Polymyalgia rheumatica (PMR) is a common inflammatory disease in elderly persons whose mechanism of pathogenesis has not been elucidated. Glucocorticoids are the main first-line treatments but result numerous side effects. Therefore, there need to explore pathogenetic factors and identify possible glucocorticoid-sparing agents. We aimed study features assess efficacy safety Janus tyrosine kinase (JAK)-inhibitor tofacitinib patients with PMR. Methods findings recruited...
Objectives Combination therapy with mycophenolate mofetil, tacrolimus and steroids are effective in achieving complete remission lupus nephritis (LN). uniquely downregulated caspase-1 compared monotherapies, which can cleave gasdermin D (GSDMD) was recently identified as the pyroptosis executioner. We therefore investigated whether combination enabled suppression of caspase-1/GSDMD-mediated LN. Methods Expression activation GSDMD were detected kidney specimens human mouse LN using...
Interferon (IFN)-inducible GTPases currently include four families of proteins: myxovirus resistant proteins (Mxs), guanylate-binding (GBPs), immunity-related GTPase (IRGs), and very large inducible (VLIGs). They are all under conserved regulation by IFNs in humans mice play a critical role preventing microbial infections. However, differences between vertebrates poorly characterized, their evolutionary origins have not been studied detail. In this study, we performed comparative genomic...
Abstract Background Vedolizumab (VDZ) and infliximab (IFX) are both recognized as first-line treatment options for moderate to severe ulcerative colitis (UC). However, there is a paucity of comparative studies examining their real-world efficacy. Methods Patients with UC were consecutively enrolled from 11 centers. Efficacy evaluated after 14 52 weeks. Logistic regression was conducted identify independent risk factors clinical remission. Results A total 235 patients enrolled, which 154...
Background/Objectives: Abiotic stresses impose significant constraints on crop growth, development, and yield. However, the comprehensive characterization of maize (Zea mays) lipoxygenase (LOX) gene family under stress conditions remains limited. LOXs play vital roles in plant responses by mediating lipid oxidation signaling pathways. Methods: In this study, 13 ZmLOX genes were identified characterized to explore their functions abiotic stresses. Results: Phylogenetics revealed that share...
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune condition that causes joint inflammation and damage significantly affects patients' quality of life. Over the past 5 years, application artificial intelligence (AI), particularly deep learning, has resulted in notable advancements field rheumatology. This review explores these developments, highlighting how AI enhanced precision reliability imaging techniques, such as radiography, ultrasound imaging, magnetic resonance for managing...
To provide real-world data and summarize current clinical evidence on the efficacy safety of sirolimus in active systemic lupus erythematosus (SLE) patients.This was a prospective study. Included SLE patients should have Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) ⩾ 2. They were treated with followed up regularly. The SLEDAI-2K, Physician Global Assessment (PGA), serological activity indices, remission organ manifestations evaluated. We also performed meta-analysis...
Background This study described clinical characteristics and outcome in systemic lupus erythematosus (SLE) patients with diffuse alveolar hemorrhage (DAH), investigated risk factors prognostic for DAH. Methods We conducted a retrospective nested case–control analysis single-center cohort. enrolled 94 SLE For each case of DAH, two age-, sex-, courses–matched controls were randomly selected from our All between 2004 2019 followed until death, end registration the physician’s practice, or...
Abstract Background Interstitial lung disease (ILD) and its rapid progression (RP) are the main contributors to unfavourable outcomes of patients with idiopathic inflammatory myopathy (IIM). This study aimed identify clinical value PET/CT scans in IIM-ILD construct a predictive model for RP-ILD. Methods Adult who were hospitalized at four divisions First Affiliated Hospital, Zhejiang University School Medicine (FAHZJU), from 1 January 2017 31 December 2020 reviewed. other characteristics met...
Objective: To elucidate the 18F-fluorodeoxyglucose (FDG) PET/CT characteristics and its prognostic value in patients with anti-melanoma differentiation associated protein 5 antibody positive (anti-MDA5+) dermatomyositis (DM). Methods: This retrospective cross-sectional study included 26 anti-MDA5+ DM 43 anti-MDA5 negative (anti-MDA5-) idiopathic inflammatory myopathy (IIM) who were examined by 18F-FDG from January 1, 2017 to December 31, 2020. The maximum standardized uptake (SUVmax) of...
Background: β 1 ‐integrins, which localize to the basolateral surface of basal keratinocytes, are important in differentiation control and proliferation epidermis. Many cutaneous diseases with perturbed differentiation, including arsenical keratosis, show altered patterns integrin distribution expression. Arsenic may induce keratosis through apoptosis aberration by integrins. The purpose this study is investigate role arsenic pathogenesis keratosis. Methods: Twenty‐five specimens obtained...
Background Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare but fatal complication in idiopathic inflammatory myopathy (IIM) patients. The clinical value of radiological manifestations and serum cytokines remain unknown this systemic crisis. This study aims to investigate the PET/CT scan cytokine profiles predicting understanding sHLH IIM Methods Adult patients who were admitted four divisions First Affiliated Hospital, Zhejiang University School Medicine (FAHZJU) from January...
16127 Background: A prior phase III trial (TARGETs) demonstrated that sorafenib doubled median progression-free survival versus placebo in previously treated clear cell renal cancer (RCC) patients (pts). The was conducted to explore the efficacy and safety profile of Chinese with advanced RCC. Methods: total 62 were enrolled for open-label, non- randomized from April 20 Dec. 28, 2006 4 hospitals China. Major inclusion criteria: Histologically confirmed unresectable and/or metastatic RCC, at...
To investigate the clinical characteristics in patients with primary antiphospholipid syndrome (PAPS) and to identify potential predictors of thrombotic events.A total 107 PAPS were enrolled our study, who admitted Peking Union Medical College Hospital from January 2004 December 2014. Demographic data, age at onset, disease duration, past history hypertension regular cigarette smoking, manifestations, imaging characteristics, management prognosis retrospectively collected. Bivariate...
Abstract Objectives This study aimed at identifying clinical and laboratory risk factors for myocardial involvement (MI) in idiopathic inflammatory myopathies (IIMs) patients as well constructing a risk-predicted nomogram prediction early identification of MI. Methods An IIMs cohort southeastern China was constructed, including 504 adult who met the inclusion exclusion criteria, were hospitalized four divisions First Affiliated Hospital, Zhejiang University School Medicine from January 1st...
Objectives The objective of this study was to investigate risk factors microvascular involvement and survival in Chinese patients with primary antiphospholipid syndrome. Methods In single-center, retrospective study, we enrolled 112 a confirmed diagnosis syndrome who were admitted Peking Union Medical College Hospital from January 2004 December 2016. Demographic data, clinical characteristics, laboratory results, follow-up records collected. Results A total studied. Microvascular identified...
Objective: To study clinical characteristics and pregnancy outcomes under anti-coagulation therapy of non-criteria obstetric antiphospholipid syndrome. Methods: Patients suspected syndrome(OAPS) were recruited through Chinese Rheumatism Data Center from 2015 to 2019 consecutively. fulfilling 2006 Sydney revised syndrome criteria classified as OAPS. definition OAPS(NCOAPS) by expert consensus on diagnosis management China NCOAPS. Clinical laboratory results two groups compared. Live birth...
Abstract Objectives Polymyalgia Rheumatica (PMR) is a common inflammatory disease in elderly persons whose pathogenesis unclear. We aimed to explore the pathogenetic features of PMR and find new therapeutic strategy. Methods included 11 patients with 20 age-matched sex-matched healthy controls (HC) this study. The were described. gene expression profiles analyzed peripheral blood mononuclear cells (PBMCs) by RNA sequencing confirmed RT-PCR. also tested five after tofacitinib therapy. Results...
ABSTRACT Background The etiology of systemic lupus erythematosus (SLE) is multifactorial. Recently, growing evidence suggests that the microbiota plays a role in SLE, yet whether gut participates development SLE remains largely unknown. To investigate this issue, we carried out 16s rDNA sequencing analyses cohort 18 female un-treated active patients and 7 healthy controls, performed fecal transplantation from controls to germ-free mice. Results Compared found no significant different...