A5101869790- Photopolymerization techniques and applications
- Immune Cell Function and Interaction
- Synthesis and properties of polymers
- Melanoma and MAPK Pathways
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Occupational and environmental lung diseases
- T-cell and B-cell Immunology
- Microbial Metabolism and Applications
- Atrial Fibrillation Management and Outcomes
- Ubiquitin and proteasome pathways
- Synthesis of Organic Compounds
- Renal cell carcinoma treatment
- Medicinal Plant Pharmacodynamics Research
- Synthesis and biological activity
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Endometrial and Cervical Cancer Treatments
- Nuclear Structure and Function
- Cancer-related gene regulation
- Renal and related cancers
- Biological Activity of Diterpenoids and Biflavonoids
- Medical Imaging and Pathology Studies
Yanbian University
2005-2025
Weatherford College
2023
Yanbian University Hospital
2015
Malignant melanoma (MM) is a highly aggressive subtype of skin cancer characterized by poor prognosis, particularly in the advanced stages. Despite advancements targeted therapy and immunotherapy, survival rates for MM remain low, underscoring need new therapeutic targets. Pleckstrin homology domain‑containing family A member 4 (PLEKHA4), which has regulatory functions pivotal cellular processes, emerged as potential target melanoma. The present study aimed to investigate role PLEKHA4...
The induction of apoptosis and antiproliferation effect cytokine-induced killer cells (CIK cells) on MGC- 803 its mechanisms were studied by using a tetrazolium dye–based (MTT) assay. Morphological changes observed inverted microscope, haematoxylin/eosin (HE) staining, scanning electron transmission microscope. TdT-mediated dUTP nick labeling (TUNEL) method was used to detect the apoptosis-induced CIK cells. expression rate p53, p16, C-myc, Bcl-2, Bax proteins immunohistochemical staining....
Malignant melanoma (MM) is highly metastatic and has the highest mortality rate in patients with skin cancer. The ERBB3 binding protein 1 (Ebp1) been linked to onset progression of a number malignancies. However, role Ebp1 MM not yet reported.Multiple databases were analyzed for comparing expression normal MM. was knocked down A375 B16 cells, impact on cell growth tested by CCK-8, plate clone colony, cycle assays. Scratch, transwell, vivo caudal vein lung metastasis tests also used confirm...
Kidney Renal Clear Cell Carcinoma (KIRC) is a common malignant tumor of the urinary system, and its incidence increasing. ERBB3 binding protein (EBP1) upregulated in various cancers. However, connection between EBP1 KIRC has not been reported.
In the present study, pleckstrin homology domain‑containing family A member 4 (PLEKHA4) was identified as being upregulated in renal cell carcinoma, particularly within kidney clear carcinoma (KIRC) subtype. The study conducted bioinformatics analysis, Cell Counting Kit‑8 and migration assays, flow cytometry, western blotting <em>in vivo</em> experiments with aim of uncovering role PLEKHA4 β‑catenin signaling KIRC cells. Notably, upregulation revealed to be associated enhanced...
Atrial natriuretic peptide (ANP) plays a pivotal role in the regulation of cardiovascular system. The ANP level increases during atrial fibrillation (AF), suggesting that AF may provoke secretion, but its potential mechanism is still unclear. In present study, mechanisms rapid pacing (RAP) regulating secretion was explored. Rabbits were subjected to burst RAP, increased whereas cyclic guanosine monophosphate (cGMP) concentrations decreased RAP. p-Akt and p-GSK-3β levels tissues. Natriuretic...