A5017427113- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Essential Oils and Antimicrobial Activity
- Peroxisome Proliferator-Activated Receptors
- Liver physiology and pathology
- Gastrointestinal motility and disorders
- Drug-Induced Hepatotoxicity and Protection
- Neuropeptides and Animal Physiology
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Gastroesophageal reflux and treatments
- Genomics, phytochemicals, and oxidative stress
- RNA Research and Splicing
- Eosinophilic Esophagitis
- Mycobacterium research and diagnosis
- Helicobacter pylori-related gastroenterology studies
Second Hospital of Shandong University
2010-2020
We aimed at the effects of long non-coding RNA (lncRNA) SNHG5 on proliferation, metastasis and migration colorectal cancer (CRC) cells. also investigated regulatory relationships among miR-132-3p, CREB5 their roles in CRC. 25 pairs samples containing CRC tissues matched para-tumor were obtained to examine SNHG5, miR-132-3p expression by qRT-PCR or Western blot. The targeted relationship between was confirmed dual luciferase report assay as well pull down assay. cells regulated cell...
This study aims to investigate the effect of miR-21-5p on process colon adenocarcinoma (COAD) cells and its connection with neural cell adhesion molecule L1 (CHL1).Different expressions mRNAs miRNAs were calculated microarray analysis. QRT-PCR western blot performed quantify CHL1 expression. Flow Cytometry, MTT assay, colony formation transwell assay ELISA evaluate propagation invasiveness COAD cells. Dual luciferase reporter was employed scrutinize relationship between miR-21-5P CHL1. We in...
Catalpol is an effective active ingredient that functions as a diuretic and laxative, exhibits blood sugar-lowering, liver protective, anti-aging anticancer effects. In traditional Chinese medicine, catalpol believed to be Yin nourishing. The effect of on human HCT116 colorectal cancer cells were investigated the mechanism action was evaluated. Cellular viability detected using MTT assay. Caspase-3 caspase-9 activity, cellular apoptosis nucleic morphology analyzed caspase-3 activity assay...
Abstract Long non‐coding RNAs have important roles in the occurrence and progression of various cancers. However, molecular mechanism lncRNAs colorectal cancer (CRC) is not well illustrated. Thus, we used bioinformatics methods to find potential associated with CRC progression, chose SH3PXD2A‐AS1 as a candidate for further analysis. The cells were determined by CCK‐8, transwell invasion, wound healing flow cytometry assays. Besides, established tumor models nude mice study effect on growth....
BACKGROUND:The effects of Helicobacter pylori (H. pylori) infection on gastroesophageal reflux disease (GERD) remain unclear. The aim this study was to compare the results clinical esophageal function tests and effect H. GERD. MATERIAL AND METHODS:A prospective included 124 patients diagnosed with GERD (four grades). determined by gastroscopy a rapid urease test (RUT) divide into an HP-positive HP-negative group. Esophageal high-resolution manometry (HRM), peristalsis break (PB), 24-hour pH...
To investigate the effect of Fuzhenghuayu compound (FZHc) on expression nuclear factor E2-related 2 (Nrf2) in hepatocytes under conditions hepatic fibrosis using a mouse model.Mice were randomly assigned to control group and model group. The was further divided into three subgroups for use as normal controls (A1), mineral oil-treated (A2), FZHc-treated (A3); administered carbon tetrachloride (CC14 dissolved oil injected intraperitoneally) four 6-weeks models (B1), 10-weeks (B2), low-dose...