A5101687482- Mesenchymal stem cell research
- Telomeres, Telomerase, and Senescence
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Liver Disease Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Retinoids in leukemia and cellular processes
- Cancer-related molecular mechanisms research
- Surgical Sutures and Adhesives
- Drug-Induced Hepatotoxicity and Protection
- Cardiac Fibrosis and Remodeling
- Cardiac Structural Anomalies and Repair
- Epigenetics and DNA Methylation
- Effects of Radiation Exposure
- Peptidase Inhibition and Analysis
- interferon and immune responses
- RNA modifications and cancer
- Organ Transplantation Techniques and Outcomes
- Insect Resistance and Genetics
- Multiple Myeloma Research and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bone and Joint Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Diseases and Glomerulopathies
Second Hospital of Shandong University
2012-2022
First Affiliated Hospital of Xinxiang Medical University
2015
Shandong University
2011-2013
The present study investigated the inhibitory effect of curcumin on human breast cancer MCF-7 cells and potential underlying molecular mechanisms. were cultured with at different concentrations time points. effects treatment cell proliferation studied using a MTT assay. Reverse transcription-quantitative polymerase chain reaction western blot analysis used to assess mRNA protein expression levels B-cell lymphoma 2 (Bcl-2) Bcl-2-associated X (Bax), nuclear factor-κ-light-chain-enhancer...
The aim of the present study was to determine protection allogeneic bone marrow mesenchymal stem cells (BMSCs) on an ischaemia/reperfusion (I/R)‑induced acute kidney injury (AKI) rat model and investigate underlying mechanisms. BMSCs were isolated cultured from adult Sprague‑Dawley (SD) rats I/R‑induced AKI established by bilateral clamping renal pedicles for 60 min. Following successfully establishing model, 1x106 administered intrarenal injection. All animals randomly divided into four...
The aim of the present study was to investigate effect bone marrow mesenchymal stem cell (BMSC) transp1antation on lung and heart damage in a rat model monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). animals were randomly divided into 3 groups: control, PAH BMSC implantation groups. Structural changes vascular wall, such as artery lumen area (VA) (TAA) measured by hematoxylin eosin (H&E) staining, hemodynamics detected echocardiography. Two weeks post-operation, our...
The aim of the present study was to evaluate effects programmed cell death 4 (PDCD4) on proliferation and apoptosis, elucidate potential role Jun N-terminal kinase (JNK)/c-Jun pathway in human bladder cancer (BCa) cells. Mixed BCa cells were transfected with plasmids containing PDCD4 (PDCD4-pcDNA3). sensitivity cisplatin analyzed using viability, invasion/migration, flow cytometry, wound healing Transwell assays at different transfection times. Furthermore, epithelial-to-mesenchymal...
Abstract Background Primary glomerulonephritis (GN) is the leading cause of chronic kidney disease (CKD) and frequently progresses into end stage renal diseases (ESRDs). Shorter leukocyte telomere length (LTL) has been implicated in CKD susceptibility diminished function, however, it unclear whether variants telomerase genes contribute to risk GN/CKD/ESRD. Here we address this issue by determining their association with genetic rs12696304 at RNA component (TERC) rs2736100 reverse...
The aim of the current study was to confirm effect and elucidate mechanism bone marrow mesenchymal stem cells (BMSCs) in acute myocardial infarction (AMI). AMI induced mini‑swine by ligating left anterior descending coronary artery, BMSCs (1x107) were injected via a sterile microinjection into ischemic area. Six months postoperatively, electrocardiograph‑gated single photon emission computed tomography revealed that filling defect reduced ventricular ejection fraction improved BMSC group...
Clear cell renal carcinoma (ccRCC) is one frequent form of urologic malignancy characterized by deregulated hypoxia-inducible factor signaling, genetic and epigenetic alterations. Metastasis the leading cause mortality from ccRCC, understanding underlying mechanism this event will provide better strategies for its management. Here, we identify tripartite motif containing 7 (TRIM7) as a tumor suppressor in ccRCC cells, which negatively regulates 1α (HIF-1α) signaling through targeting...
To explore the mechanism whereby stem cell factor (SCF) and granulocyte colony-stimulating (G-CSF) jointly mobilize bone marrow cells (BMSCs) promote kidney repair, male Sprague-Dawley rats were randomly assigned into 4 groups. In treatment control group, administered SCF (200 μg·kg(-1)·day(-1)) G-CSF (50 μg·kg-1·day-1) for 5 days. RIRI models established, 6 h later, model groups, tubular epithelial degeneration necrosis noticed, but extent of repair in group was significantly better than...
Human thrombin activatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2), is a procarboxypeptidase enzyme. The purpose of the present study was to observe expression TAFI in breast cancer (BC) and cell (BCC) lines investigate effect suppression by small interfering (si)RNA gene silencing on invasion migration BCC lines. A significant increase level identified immunohistochemical analysis BC tissues compared with normal tissues. inhibited viability, ability...
The aim of the present study was to investigate association human leukocyte antigen (HLA) gene polymorphism and clinical phenotypes patients with mesangial proliferative glomerulonephritis (MsPGN). genotyping HLA-A, HLA-B HLA-DRB1 alleles detected in 1,536 consecutive MsPGN during previous five years 2,027 age- gender-matched healthy individuals by using polymerase chain reaction-sequence-specific primers method. pathological data were collected genotype frequencies (GF) odds ratio (OR)...
PURPOSE: To explore the mechanism of resistance to IKKβ inhibitor in multiple myeloma (MM) cells and uncover novel therapeutic targets for MM. METHODS: We downloaded microarray data (GSE8476) from GEO (Gene Expression Omnibus) database. The were derived human MM lines (L363 cells) treated with MLN120b (MLN) eight, 12 24 hours. Furthermore, we applied Search Tool Retrieval Interacting Genes (STRING) Analysis Systematic Explorer (EASE) database construct protein-protein interaction networks...
To investigate the effect of Fuzhenghuayu compound (FZHc) on expression nuclear factor E2-related 2 (Nrf2) in hepatocytes under conditions hepatic fibrosis using a mouse model.Mice were randomly assigned to control group and model group. The was further divided into three subgroups for use as normal controls (A1), mineral oil-treated (A2), FZHc-treated (A3); administered carbon tetrachloride (CC14 dissolved oil injected intraperitoneally) four 6-weeks models (B1), 10-weeks (B2), low-dose...
To investigate chronic hepatitis B (CHB) patients infected with the antiviral-resistant rtA181 mutation virus (HBV) who have been unresponsive to general therapy determine effects of individualized therapy.Fifty-four confirmed and experienced virological breakthrough during nucleus(t)ide analogue (NUC) treatment were enrolled in this prospective cohort study. Their serum levels HBV DNA, surface antigen (HBsAg), alanine transaminase (ALT) tested. Each patient was genotyped by pyrosequencing...
Stitching skin wounds is one of the essential skills a surgeon. Whether it traumatic wound or surgical incision, choosing most appropriate closure technique according to its characteristics an important factor for good healing. Various suturing techniques have been created and improved over years, which advantages simple operation, precise alignment, reducing tension edges, scar formation, etc. Although these provide more options suture, they also put forward requirements judgment operation...