A5100329690- Angiogenesis and VEGF in Cancer
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmaceutical studies and practices
- Protease and Inhibitor Mechanisms
- Spinal Fractures and Fixation Techniques
- Anesthesia and Sedative Agents
- Bone Tumor Diagnosis and Treatments
- Spine and Intervertebral Disc Pathology
- Advanced MRI Techniques and Applications
- Retinal Diseases and Treatments
- Retinopathy of Prematurity Studies
- Medical Imaging and Analysis
- Nutrition and Health in Aging
- Cardiovascular Disease and Adiposity
- Total Knee Arthroplasty Outcomes
- Folate and B Vitamins Research
- Traumatic Ocular and Foreign Body Injuries
- Spinal Hematomas and Complications
- MRI in cancer diagnosis
Shenzhen University
2025
Chinese University of Hong Kong, Shenzhen
2021-2025
Chinese University of Hong Kong
2017-2025
Tianjin Medical University General Hospital
2014-2024
Second Affiliated Hospital of Jilin University
2021-2024
North University of China
2017-2023
Nanjing University
2023
Shenzhen Institutes of Advanced Technology
2021-2023
Weatherford College
2021
Chinese Academy of Sciences
2021
For scaling clearance between adults and children, allometric with a fixed exponent of 0.75 is often applied. In this analysis, we performed systematic study on the for propofol two subpopulations selected from neonates, infants, toddlers, adolescents adults.
In order to characterize the variation in pharmacokinetics of paracetamol across human age span, we performed a population pharmacokinetic analysis from preterm neonates adults with specific focus on clearance. Concentration-time data obtained 220 (post-natal 1-76 days, gestational 27-42 weeks), infants (0.11-1.33 yrs), children (2-7 yrs) and (19-34 were analyzed using NONMEM 7.2. covariate analysis, linear functions, power function bodyweight-dependent exponent tested. Between adults,...
and colleagues
Beige adipocytes are thermogenic with high expression of uncoupling protein 1 in the white adipose tissue (WAT), accompanied by angiogenesis. Previous studies showed that Smad4 is important for Here we studied whether endothelial Smad4-mediated angiogenesis involved WAT beiging. Inducible knockout cell (EC) selective (Smad4iEC-KO) was achieved using Smad4Floxp/floxp and Tie2CreERT2 mice. fat induction cold or adrenergic agonist, were attenuated Smad4iEC-KO mice, less proliferation ECs...
Hyperhomocysteinemia (HHcy) is considered as a risk factor for several complications, including cardiovascular and neurological disorders. A high methionine low folate (HMLF) diet chronically causes HHcy by accumulating homocysteine in the systemic circulation. Elevated Hcy level also associated with incidence of diabetes mellitus. However, very few studies focus on impact HMLF glucose homeostasis, that gut microbiome profile. was induced feeding C57BL/6 mice 8 weeks. The resulted...
Abstract Recent studies have demonstrated that hypertension correlates with tumorigenesis and prognosis of clear-cell renal cell carcinoma (ccRCC); however, the underlying molecular mechanisms remain unclear. By analyzing bulk single-cell RNA sequencing data experimental examining surgical excised ccRCC samples, we found tissue inhibitors metalloproteinases 3 (TIMP3), a pivotal paracrine factor in suppressing tumor progression, was significantly reduced endothelial cells patients...
Despite the great strides made in imaging breast cancer (BC) humans, current modalities miss up to 30% of BC, do not distinguish malignant lesions from benign ones, and require histologic examinations for which invasive biopsy must be performed. Annually United States, approximately 5.6 million biopsies find lesions. More than 50% human BCs overexpress cyclin D1, all exhibit VPAC1 oncogene products. Together, these gene products may provide an excellent biomarker early accurate detection BC....
Summary Acute lung injury is a condition that characterized by acute onset of severe hypoxaemia and bilateral pulmonary infiltrates. Patients typically require mechanical ventilation in an intensive care unit. Low tidal volume (LTVV), which time varying dynamic treatment regime, has been recommended as effective strategy. This recommendation was based on the results randomized clinical trial designed to compare low versus high strategies Respiratory Distress Syndrome Network. After...
Machine learning (ML) is increasingly used to predict the prognosis of numerous diseases. This retrospective analysis aimed develop a prediction model using ML algorithms and identify predictors associated with recurrence hallux valgus (HV) following surgery.
Successful practice of clinical deep brain stimulation (DBS) calls for basic research on the mechanisms and explorations new indications in animals. In article, a implantable, single-channel, low-power miniature device is proposed, which may transmit pulses chronically into nucleus freely moving rats. The DBS system consists an implantable pulse generator (IPG), bipolar electrode, external programmer. IPG circuit module assembled as 20-mm diameter circular board fixed rat's skull together...