A5101581573- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Bone Tumor Diagnosis and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Hypoxia, and Metabolism
- Liquid Crystal Research Advancements
- Photonic Crystals and Applications
- Sarcoma Diagnosis and Treatment
- RNA Research and Splicing
- TiO2 Photocatalysis and Solar Cells
- Advanced Photocatalysis Techniques
- MicroRNA in disease regulation
- Metamaterials and Metasurfaces Applications
- Wnt/β-catenin signaling in development and cancer
- Metabolism, Diabetes, and Cancer
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Biochemical Acid Research Studies
- Pancreatic and Hepatic Oncology Research
- Pregnancy and Medication Impact
Imperial College London
2023
Shanghai Medical Information Center
2022-2023
Second Military Medical University
2016-2022
Jilin University
2009-2021
First Hospital of Jilin University
2021
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
2014-2016
Jilin Medical University
2014-2015
Duke University Hospital
2012
Duke Medical Center
2012
Duke University
2012
Metformin, an ancient drug commonly used for treating type II diabetes, has been associated to anti-cancer capacity in a variety of developing cancers, though the mechanism remains elusive. Here, we aimed examine inhibitory effect metformin osteosarcoma. Herein, demonstrated that treatment blocked proliferation progression by causing accumulation G2/M phase U2OS and 143B cells. Furthermore, triggered programmed cell death process osteosarcoma lines. Further research indicated induction...
// Xin-gang Cui 2, * , Zhi-tao Han 1, 6, Shao-hui He Xing-da Wu 3, Tian-rui Chen 1 Cheng-hao Shao 4 Dan-lei Ning Su 5 Yuan-ming 6 Ting Wang Jing Dian-Wen Song Wang-jun Yan Xing-Hai Yang Tielong Liu Hai-feng Wei Jianru Xiao Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China 2 Urinary Surgery Third Affiliated 3 Pancreatic the First Hospital Shenyang, Colorectal Spine Ruikang Guangxi University Of Chinese Medicine, Guangxi, Cui, Han, He,...
Most patients with breast cancer in advanced stages of the disease suffer from bone metastases which lead to fractures and nerve compression syndromes. microRNA dysregulation is an important event bone. microRNA-124 (miR-124) has been proved inhibit progression, whereas its effect on not reported. Therefore, this study aimed investigate role underlying mechanism miR-124 cancer. In situ hybridization (ISH) was used detect expression tissues metastatic tissues. Ventricle injection model...
Abstract The Wnt/β-catenin signaling is abnormally activated in the progression of hepatocellular carcinoma (HCC). BCL9 an essential co-activator signaling. Importantly, absent from tumors originating normal cellular counterparts and overexpressed many cancers including HCC. But mechanism for overexpression remains unknown. Ample evidence indicates that hypoxia inducible factors (HIFs) play a role development It was found our study both primary HCC bone metastasis specimens; loss inhibited...
Photonic crystals incorporating with plasmonic nanoparticles have recently attracted considerable attention due to their novel optical properties and potential applications in future subwavelength optics, biosensing data storage device. Here we demonstrate a free-standing chiral film composed of entropy-driven self-co-assembly gold (GNPs) rod-like cellulose nanocrystals (CNCs). The CNCs–GNPs composite films not only preserve the photonic ordering CNCs matrix but also retain resonance GNPs,...
Plasmonic materials with large chiroptical activity at visible wavelength have attracted considerable attention due to their potential applications in metamaterials. Here we demonstrate a novel guest-host chiral nematic liquid crystal film composed of bulk self-co-assembly the dispersed plasmonic silver nanowires (AgNWs) and cellulose nanocrystals (CNCs). The AgNWs-CNCs composite films show strong optical activities, that are dependent on photonic properties CNCs host medium orientation...
Tissue and cell type highly specific Cre drivers are very rare due to the fact that most genes or promoters used direct expressions generally expressed in more than one tissues and/or multiple types. We developed a split-intein based split-Cre system for efficient Cre-reconstitution through protein splicing. This split-intein-split-Cre can be intersect expression patterns of two restrict full-length reconstitution their overlapping domains. To test this vivo, we selected several conserved...
Hierarchical chiroptical activity of emissive YVO<sub>4</sub>:Eu<sup>3+</sup> nanoparticles in chiral nematic cellulose host matrix.
Hierarchically nanostructured TiO<sub>2</sub> has been hydrothermally synthesized using cellulose as a biotemplate involving various types of acids.
Although emerging studies have implicated that Aiopoietin-like 4 Protein (ANGPTL4) is related to the aggressiveness and metastasis of many tumors, role ANGPLT4 in giant cell tumor (GCT) bone was rarely investigated. The mechanism tumor-induced osteoclastogenesis still remains unclear. In this study, we first demonstrated ANGPTL4 highly expressed GCT compared normal tissues, while showed TGF-β2 released by osteoclasts induced resorption could increase expression GCTSCs. By using luciferase...
B-cell CLL/lymphoma 9 protein (BCL-9), a multi-functional co-factor in Wnt signaling, induced carcinogenesis as well promoting tumor progression, metastasis and chemo-resistance colorectal cancer (CRC). However, the mechanisms for increased BCL-9 expression CRC were not understood. Here, we report that hypoxia, hallmark of solid tumors, mRNA human cells. Analysis promoter revealed two functional hypoxia-responsive elements (HRE-B HRE-C) can be specifically bound with transactivated by...
Giant cell tumor (GCT) of bone is a common primary tumor, which exhibits local aggressiveness and recurrent potential, especially for the spinal lesion. Increasing evidence indicates that inflammation plays vital role in tumorigenesis progression. The prognostic value inflammatory biomarkers GCT has not been established. A retrospective analysis was conducted patients with Changzheng Hospital Orthopedic Oncological Center (CHOOC) between January 2005 October 2015 129 were identified...
Study Design. A retrospective study was performed. Objective. The aim of the to illustrate long-term follow-up results and discuss possible factors that may affect outcomes patients with cervical spinal nerve sheath tumors (CSNSTs). Summary Background Data. Nerve are most common neoplasms in spine, but minimal information published literature, especially when regarding prognostic due benign nature. objective our present CSNSTs. Methods. analysis CSNSTs performed by survival analysis. local...
Alzheimer's disease (AD) is characterized by cognitive decline due to the accumulation of extracellular β-amyloid (Aβ) plaques and neurofibrillary tangles in brain, which impair glutamate (Glu) metabolism. Deproteinized Calf Blood Extractive Injection (DCBEI) a biopharmaceutical that contains 17 types amino acids 5 nucleotides. In this study, we found DCBEI pretreatment reduced L-Glu-dependent neuroexcitation toxicity maintaining normal mitochondrial function HT22 cells. treatment also...
Neuroblastoma is the most common extracranial neuroendocrine tumor in childhood. Although many studies have tried to find effective treatments, there are still numerous limitations current clinical targeted therapy. So, it important new therapeutic targets and strategies from a perspective. Our previous study reported that androgen receptor (AR) promotes growth of neuroblastoma vitro vivo . Based on documentary investigation, we postulated AR–SCAP–SREBPs-CYP17/HMGCR axis may regulate...
BACKGROUND: Giant cell tumor of bone (GC), osteosarcoma (OS) and Ewing’s sarcoma (ES) are three different types cancer with common specific pathology features. OBJECTIVE: The purpose the study was to examine relationship differences tumors using clinical samples. METHODS: Through screening profiles samples from GC, OS ES patients a humanoncology array, we found 26, 25 15 tumorigenesis factors significantly increased in GS, tissues compared normal individuals. eNOS, endostatin, HIF-1α, IL-6,...
Deep learning models have achieved the state of art in blood glucose (BG) prediction, which has been shown to improve type 1 diabetes (T1D) management. However, most existing can only provide single-horizon prediction and face a variety real-world challenges, such as lacking hardware implementation interpretability. In this work, we introduce new deep framework, edge-based temporal fusion Transformer (E-TFT), for multi-horizon BG implement trained model on customized wristband with system...
Zinc oxide aerogel-like materials with interconnected porosity and large specific surface area have been prepared, showing excellent ethanol sensing properties.
Abstract Vitamin D deficiency has recently become a global public health problem. However, it is still unclear if gene polymorphisms in the vitamin pathway influence levels among pregnant women Eastern and Central China. The objective of this study was to assess factors influencing women. A total 326 participants Shandong Henan provinces China were enrolled from August 2017 April 2019. Serum 25(OH)D single nucleotide (SNPs) measured using blood samples collected first trimester, second third...