A5076937932- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Ion channel regulation and function
- ECG Monitoring and Analysis
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- RNA Research and Splicing
- Sports injuries and prevention
- Analog and Mixed-Signal Circuit Design
- RNA and protein synthesis mechanisms
- Coronary Interventions and Diagnostics
- Electrochemical Analysis and Applications
- Neuroscience and Neural Engineering
- Genetics and Physical Performance
- Cardiac Structural Anomalies and Repair
- Forensic and Genetic Research
- Neurological disorders and treatments
- Vascular Procedures and Complications
- Cardiovascular Issues in Pregnancy
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Academic Writing and Publishing
- Molecular Biology Techniques and Applications
University of Sassari
2023-2024
Azienda Ospedaliera Universitaria Senese
2024
Ospedale SS. Annunziata
2023
Associazione Istituzione Libera Università Nuorese
2019
October 6 University
2018
Universitat de Barcelona
2007-2017
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2007-2017
Hospital Clínic de Barcelona
2007-2016
Abstract Background and Aims Available data on continuous rhythm monitoring by implantable loop recorders (ILRs) in patients with Brugada syndrome (BrS) are scarce. The aim of this multi-centre study was to evaluate the diagnostic yield clinical implication a strategy ILRs large cohort BrS assess precise arrhythmic cause syncopal episodes. Methods A total 370 (mean age 43.5 ± 15.9, 33.8% female, 74.1% symptomatic) from 18 international centers were included. Patients followed for median...
Current guidelines recommend stopping oral anticoagulation (OAC) and starting heparin infusion before implanting/replacing a pacemaker/implantable cardioverter-defibrillator (ICD) in patients with high risk for thrombo-embolic events. The aim of this study was to demonstrate that the maintenance OAC during device implantation/replacement is as safe bridging intravenous shortens in-hospital stay. A cohort 101 consecutive embolic events indication implant/replacement pacemaker/ICD were...
Young (<18 years of age) patients with Brugada syndrome (BrS) are often under-represented in BrS studies and their management, especially related to syncopal episodes, remains unclear.
Abstract Aims To define the clinical characteristics and long-term outcomes of a large cohort patients with idiopathic ventricular fibrillation (IVF) normal 12-lead electrocardiograms (ECGs). Methods results Patients as presenting rhythm, baseline, follow-up ECGs no signs cardiac channelopathy including early repolarization or atrioventricular conduction abnormalities, without structural heart disease were included in registry. A total 245 (median age: 38 years; males 59%) recruited from 25...
Background Brugada syndrome (BrS) is a rare genetic cardiac arrhythmia that can lead to sudden death in patients with structurally normal heart. Genetic variations SCN5A be identified approximately 20-25% of BrS cases. The aim our work was determine the spectrum and prevalence Spanish cohort diagnosed BrS. Methodology/Principal Findings We directly sequenced fourteen genes reported associated 55 unrelated clinically diagnosed. Our screening allowed identification 61 variants. Of them, 20...
Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a cardiac disease characterized by the presence of fibrofatty replacement myocardium, which may cause arrhythmias and sudden death. Pathogenic mutations in several genes encoding mainly desmosomal proteins have been reported. Our aim to perform genotype-phenotype correlations establish diagnostic value genetics assess role mutation type age-related penetrance ARVC. Methods Results Thirty unrelated Spanish patients underwent...
Little is known about the distribution and clinical course of patients with inherited arrhythmia syndrome (IAS) concomitant atrial arrhythmias (AAs).
Cardiac arrhythmias in pregnant women are a common entity and often drug‐refractory. The major concern about using radiofrequency (RF) catheter ablation guided by fluoroscopy to treat during pregnancy is the potential consequences of exposing fetus radiation. We present two patients with incessant life‐threatening supraventricular tachycardias successfully treated conventional RF under strict radioactive dosimeter surveillance. availability better lead shielding techniques allows perform...
The aim of this study was to investigate the outcomes left atrial appendage occlusion (LAAO) in high bleeding risk patients suffering fibrillation (AF) and analyze different antithrombotic therapies following intervention.This monocentric included 68 with nonvalvular AF an absolute contraindication OAT or at risk. Follow-up done a clinical visit 3-6-12 months.Successful LAAO achieved 67/68 patients. At discharge, 32/68 were on dual antiplatelet therapy (APT), 34/68 without any single drug,...
AimsThe need for antiarrhythmic drugs (AAD) after a first episode of atrial fibrillation (AF) is determined by the probability recurrence. The aim this study was to asses relapse and predictors recurrence in patients with idiopathic AF.
Subcutaneous implantable cardioverter defibrillators (S-ICDs) avoid complications secondary to transvenous leads, but inappropriate shocks (ISs) are frequent. Furthermore, IS data from patients with Brugada syndrome (BrS) an S-ICD scarce.We aimed establish the frequency and predictors of in this population.We analyzed clinical electrocardiographic characteristics, automated screening test data, device programming, occurrence adult BrS S-ICD.Thirty-nine were enrolled (69% male, mean age at...
Brugada syndrome is an inherited cardiac condition transmitted with autosomal dominant pattern which can lead to sudden death from malignant ventricular arrhythmias. The RANGRF gene has recently been proposed be associated syndrome. This encodes the MOG1 protein, a co-factor required for full functioning of sodium channel Nav1.5. nonsense p.E61X genetic variation in postulated as responsible although no clear association established.We clinically and genetically evaluated Spanish family...
Ajmaline challenge can unmask subcutaneous implantable cardioverter-defibrillator (S-ICD) screening failure in patients with Brugada syndrome (BrS) and non-diagnostic baseline electrocardiogram (ECG). The efficacy of the SMART Pass (SP) filter, a high-pass filter designed to reduce cardiac oversensing (while maintaining an appropriate sensing margin), has not yet been assessed BrS. aim this prospective multicentre study was investigate effect SP on dynamic ECG changes evoked by ajmaline...
Background Chronic diseases have a negative impact on quality of life (QOL) and psychological health. There are limited related data regarding this topic in Brugada syndrome (BrS). We evaluated the effects diagnosis BrS health-related QOL status among patients their relatives. Methods Patients with relatives underwent evaluation at (T0), 1 2 years after (T1 T2) using questionnaires mental QOL, anxiety, depression, stress, post-traumatic resilience resources. Results Sixty-one 39 were...