A5022123282- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ion channel regulation and function
- Venous Thromboembolism Diagnosis and Management
- Analog and Mixed-Signal Circuit Design
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Abdominal vascular conditions and treatments
- Cardiac Imaging and Diagnostics
- Frailty in Older Adults
- Antiplatelet Therapy and Cardiovascular Diseases
- Nutrition and Health in Aging
- Neural Networks and Applications
- Heart Failure Treatment and Management
- Advanced MRI Techniques and Applications
- Renal and Vascular Pathologies
- Inhalation and Respiratory Drug Delivery
- Airway Management and Intubation Techniques
Regione Toscana
2016-2024
Fondazione Toscana Gabriele Monasterio
2010-2024
Istituto di Fisiologia Clinica
2005-2024
Ca' Foncello Hospital
2024
Azienda Ospedaliera Universitaria Senese
2024
Scuola Superiore Sant'Anna
2024
University of Pisa
2024
Azienda Ospedaliera Universitaria Pisana
2024
AULSS 2 Marca Trevigiana
2022
University of Verona
2012-2015
Abstract Background and Aims Available data on continuous rhythm monitoring by implantable loop recorders (ILRs) in patients with Brugada syndrome (BrS) are scarce. The aim of this multi-centre study was to evaluate the diagnostic yield clinical implication a strategy ILRs large cohort BrS assess precise arrhythmic cause syncopal episodes. Methods A total 370 (mean age 43.5 ± 15.9, 33.8% female, 74.1% symptomatic) from 18 international centers were included. Patients followed for median...
BackgroundThere are limited real-world data about the extended prognosis of patients with drug-induced type 1 Brugada electrocardiogram (ECG).ObjectiveWe assessed clinical outcomes and predictors life-threatening arrhythmias in ECG.Materials MethodsThis multicenter retrospective study, conducted at 21 Italian Swiss hospitals from July 1997 to May 2021, included consecutive ECG. The primary outcome, a composite appropriate ICD therapies sudden cardiac death (SCD), was along these...
Young (<18 years of age) patients with Brugada syndrome (BrS) are often under-represented in BrS studies and their management, especially related to syncopal episodes, remains unclear.
Background: Atrioventricular (AV) interval optimization, ensuring the best filling and abolishment of presystolic mitral regurgitation, is crucial for efficacy cardiac resynchronization therapy (CRT). The methods proposed to optimize AV delay have many limitations. maximum left ventricular pressure derivative (LV dP/dt)—an index performance—could provide a clue optimization. DP/dt can be calculated by Doppler curve regurgitation jet it related micromanometer‐derived dP/dt. Aim: aim this...
Artificial Intelligence (AI) applications and Machine Learning (ML) methods have gained much attention in recent years for their ability to automatically detect patterns data without being explicitly taught rules. Specific features characterise the ECGs of patients with Brugada Syndrome (BrS); however, there is still ambiguity regarding correct diagnosis BrS its differentiation from other pathologies.This work presents an application Echo State Networks (ESN) Recurrent Neural (RNN) class...
In patients with atrial fibrillation (AF) pharmacological or electrical cardioversion may be performed to restore sinus rhythm. The procedure is associated an increased risk of thromboembolic events, which can significantly reduced by adequate anticoagulation (OAC). Our aim was create a partly prospective, retrospective registry, particularly focusing on OAC strategies in different European countries, and emerging choice over time.From September 2014 October 2015, cardioversions due AF six...
Abstract Background Radiofrequency ablation has been shown to be a safe and effective treatment for scar-related ventricular arrhythmias (VA). Recent preliminary studies have that real time integration of late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) images with electroanatomical map (EAM) data may lead increased procedure efficacy, efficiency, safety. Methods VOYAGE is prospective, randomized, multicenter controlled open label study designed compare in terms safety CMR...
Abstract Aims To investigate the prognostic significance of heterogeneity in refractoriness right ventricular (RV) outflow tract (RVOT) and RV apex at electrophysiological study (EPS) Brugada syndrome (BrS). Methods results A cohort BrS patients (primary prevention) from five Italian centres was retrospectively analysed. Patients with spontaneous or drug-induced Type-1 electrocardiogram (ECG) + symptoms were offered an EPS for stratification. The primary endpoint a composite sudden cardiac...
Brugada Syndrome (BrS) is a primary electrical epicardial disease characterized by ST-segment elevation followed negative T-wave in the right precordial leads on surface electrocardiogram (ECG), also known as ‘type 1’ ECG pattern. The risk stratification of asymptomatic individuals with spontaneous type 1 pattern remains challenging. Clinical and electrocardiographic prognostic markers are known. As none these predictors alone highly reliable terms arrhythmic prognosis, several multi-factor...
The subcutaneous implantable cardioverter-defibrillator (S-ICD) is a new technology for the management of ICD patients. But what patients' perspective? Previous studies on transvenous (TV-ICD) showed that device implantation related not only to anxiety and depression because fear shocks, but also many biopsychosocial factors like body image changes, perceived reduction socialization limitation in professional sports activities. Anxiety distress are more evident younger women aesthetic...
The best ablation treatment for persistent atrial fibrillation (PeAF) patients is still debated. vein of Marshall (VOM) seems to be a promising target and could combined with linear set lesions. aim our study evaluate the incidence AF recurrences in PeAF population treated comprehensive approach consisting VOM ethanol infusion (EI), pulmonary isolation (PVI), left (LA) roofline, mitral line (guided by newly formed lesion after alcohol into validated pacing), cavotricuspid isthmus...
Chronic right ventricular (RV) apical pacing may lead to left (LV) dyssynchrony and LV dysfunction. In heart failure due RV pacing, upgrading biventricular stimulation (CRT) can improve NYHA Class function. A proportion of patients do not respond upgrading. Aim was assess whether etiology dysfunction accounts for responses CRT in RV-paced patients. Sixty-two treated by CRT, under from 50.2 ± 5.4 months, were studied. Cause non-ischemic (NIC) 28 ischemic cardiomyopathy (IC) 34 Clinical...
Abstract Background Transmural voltage gradient in RVOT induces ECG–phenotype Brugada syndrome(BrS). Moreover,RVOT depolarization abnormalities have been described as contributors to BrS phenotype and arrhythmogenesis. Purpose To investigate the effect of ajmaline administration on J–elevation unipolar signals patients. Moreover,we wanted assess whether ajmaline–induced J–point elevation variations induced local abnormalities. Methods 21 patients with spontaneous type–1 ECG pattern were...
Abstract Introduction Adults with repaired tetralogy of Fallot (rToF) are most often referred to Adult Congenital Heart Disease centers for atrial tachycardia (AT) and radiofrequency catheter ablation (RFCA) is required. A systematic evaluation the mechanisms recurrences arrhythmias in these patients lacking. Methods 28 rToF Interventional Electrophysiology Unit our center between January 2013 2023 were evaluated. Pts underwent electrophysiologic study (EPS) 3D electroanatomic high density...
Abstract Introduction Adults with repaired tetralogy of Fallot (rToF) are prone to develop ventricular tachycardia (VT) in adulthood, due reentry related slowly conducting anatomical isthmuses (SCAI). Pulmonary valve replacement (PVR) patients without history VT, may lead obliteration unrecognized SCAI subsequent catheter ablation failure; electrophysiologic study is thus recommended before PVR. A systematic evaluation the topology this population is, however, scant. Methods Consecutive rToF...
Abstract Background Coved-type electrocardiographic (ECG) pattern of patients with Brugada syndrome (BrS) is secondary to action potential lengthening in the right ventricular outflow tract (RVOT) epicardium. This may be approximated by activation-recovery interval (ARI), a marker local repolarization dispersion. Purpose Our aim was examine epicardial dispersion ARI RVOT BrS and its correlation conduction slowing Tpeak-Tend (Tpe) interval, altered on surface ECG previously associated higher...