A5008909218- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ion channel regulation and function
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Acute Ischemic Stroke Management
- Cardiac Imaging and Diagnostics
- ECG Monitoring and Analysis
- Venous Thromboembolism Diagnosis and Management
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
- Cardiac Health and Mental Health
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- Orthopedic Infections and Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
Hospital Universitario Puerta de Hierro Majadahonda
2015-2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2021-2024
Instituto de Salud Carlos III
2024
ERN GUARD-Heart
2024
Centro de Investigación Biomédica en Red
2021-2024
Hospital Universitario 12 De Octubre
2020
Klinikum Darmstadt
2011
Catheter ablation (CA) is a highly effective therapy for the treatment of paroxysmal atrial fibrillation (AF) when compared with antiarrhythmic drug (ADT). No randomized studies have two strategies in persistent AF. The present trial aimed to compare effectiveness CA vs. ADT treating Patients AF were randomly assigned or (excluding patients long-standing AF). Primary endpoint at 12-month follow-up was defined as any episode flutter lasting >24 h that occurred after 3-month blanking period....
Background— An implantable cardioverter-defibrillator (ICD) is the therapy of choice for primary prevention in patients with ischemia who are at risk sudden cardiac death (SCD). One third significant coronary disease have chronic total occlusion (CTO), which associated long-term mortality previous myocardial infarction. However, impact CTO on occurrence ventricular arrhythmias and ICD recipients remains unknown. Methods Results— All consecutive artery receiving SCD were included study. Among...
Objective: Cardiac amyloid infiltration can lead to systolic heart failure (HF) or conduction disorders (CD). Patients with transthyretin (ATTR) amyloidosis are particularly exposed. We sought determine the prevalence of ATTR and AL among patients >60 years admitted CD unexplained HF increased wall thickness. Materials Methods: studied 143 (57% males, 79 ± 9 years) (N = 28) requiring pacemaker implantation 115). In total, 139 (97%) (28 111 CD) underwent 99mTc-DPD scintigraphy detect ATTR,...
Background Brugada syndrome (BrS) is a rare genetic cardiac arrhythmia that can lead to sudden death in patients with structurally normal heart. Genetic variations SCN5A be identified approximately 20-25% of BrS cases. The aim our work was determine the spectrum and prevalence Spanish cohort diagnosed BrS. Methodology/Principal Findings We directly sequenced fourteen genes reported associated 55 unrelated clinically diagnosed. Our screening allowed identification 61 variants. Of them, 20...
Brugada syndrome (BrS) is a life-threatening, inherited arrhythmogenic associated with autosomal dominant mutations in SCN5A, the gene encoding cardiac Na+ channel alpha subunit (Nav1.5). The aim of this work was to characterize functional alterations caused by novel SCN5A mutation, I890T, and thus establish whether mutation BrS. identified direct sequencing from proband's DNA. Wild-type (WT) or I890T Nav1.5 channels were heterologously expressed human embryonic kidney cells. Sodium currents...
The term embolic stroke of undetermined source (ESUS) has been defined for patients with ischemic strokes, where neither a cardioembolic nor non-cardiac can be detected. These may have asymptomatic episodes atrial fibrillation (AF). Prolonged monitoring implantable loop recorder (ILR) and daily remote interrogation in after an ESUS shown incidence AF about 25%.The main objective this study was to analyze the predictive factors who underwent ILR implantation.It single center study. From June...
Abstract Background and Objectives The common practice after atrial fibrillation ablation is to admit patients for an overnight stay. aim of this study was compare a strategy vascular suture mediated closure system utilization early discharge (strategy A) compared traditional hospitalization B) regarding feasibility, safety, quality life health care cost effectiveness. Methods Results Hundred were randomized both strategies. No clinical differences reported except diabetes mellitus. Six (6%)...
Conventional right ventricle (RV) pacemaker stimulation has been associated with worse clinical outcomes in patients cardiac amyloidosis (CA). Left bundle branch area pacing (LABPP) suggested as a promising alternative. We sought to assess the safety, feasibility, and of LABPP CA.
Implantable cardioverter defibrillators (ICDs) are increasingly being used for treatment of ventricular tachycardia (VT)/fibrillation. Inappropriate therapy delivery remains the most frequent complication in patients with ICDs, resulting psychological distress, proarrhythmia, and battery life reduction. We aim to determine if inappropriate therapies could be reduced by using a morphology discrimination criterion. evaluated performance Wavelet™ algorithm (Medtronic, Inc.) independently from...
Although sudden death (SD) is a recognized complication of cardiac amyloidosis, there scarce data about its incidence, mechanisms, and predictors. The aim this study was to describe incidence SD analyze possible risk factors.
Objective We sought to investigate prevalence, incidence and prognostic implications of permanent pacemaker (PPM) implantation in patients with cardiac amyloidosis (CA), thereby identifying the predictors time PPM implantation. Methods Seven hundred eighty-seven CA (602 men, median age 74 years, 571 transthyretin (ATTR), 216 light-chain (AL)) evaluated at two European referral centres were retrospectively included. Clinical, laboratory instrumental data analysed. The associations between...