A5069220450- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Neurological disorders and treatments
- Cardiomyopathy and Myosin Studies
- Advanced MRI Techniques and Applications
- Cardiovascular Effects of Exercise
- EEG and Brain-Computer Interfaces
- Vascular anomalies and interventions
- Tissue Engineering and Regenerative Medicine
- Mechanical Circulatory Support Devices
- Business, Innovation, and Economy
- Heart Rate Variability and Autonomic Control
- Electrospun Nanofibers in Biomedical Applications
- Congenital Heart Disease Studies
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Cardiac and Coronary Surgery Techniques
Hospital General Universitario Gregorio Marañón
2016-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2025
Centro de Investigación Biomédica en Red
2013-2025
Instituto de Salud Carlos III
2017-2024
Madrid Health Service
2024
Universidad Complutense de Madrid
2010-2022
Centre for Biomedical Network Research on Rare Diseases
2020-2022
Universitat Politècnica de València
2013-2018
Hospital Universitario Infanta Leonor
2018
Sociedad Española de Cardiología
2005-2016
Using more intervals to detect ventricular tachyarrhythmias has been associated with reducing unnecessary implantable cardioverter-defibrillator (ICD) therapies.To determine whether using 30 of 40 arrhythmias (VT) (long detection) during spontaneous fast VT episodes reduces antitachycardia pacing (ATP) and shock delivery than 18 24 (standard detection).Randomized, single-blind, parallel-group trial that enrolled 1902 primary secondary prevention patients (mean [SD] age, 65 [11] years; 84%...
Catheter ablation (CA) is a highly effective therapy for the treatment of paroxysmal atrial fibrillation (AF) when compared with antiarrhythmic drug (ADT). No randomized studies have two strategies in persistent AF. The present trial aimed to compare effectiveness CA vs. ADT treating Patients AF were randomly assigned or (excluding patients long-standing AF). Primary endpoint at 12-month follow-up was defined as any episode flutter lasting >24 h that occurred after 3-month blanking period....
Endocardial mapping before sustained monomorphic ventricular tachycardia (SMVT) induction may reduce time during and facilitate the ablation of unmappable VT.Left electroanatomic voltage maps obtained right apex pacing in 26 patients with chronic myocardial infarction referred for VT were analyzed to identify conducting channels (CCs) inside scar tissue. A CC was defined by presence a corridor consecutive electrograms differentiated higher amplitude than surrounding area. The effect...
Background— It is unclear whether atrial fibrillation (AF) drivers in humans are focal or reentrant. To test the hypothesis that functional reentry involved human AF maintenance, we determined effects of adenosine infusion on local dominant frequency (DF) at different sites. By increasing inward rectifier potassium channel conductance, would increase DF reentrant but decrease it case a mechanism. Methods and Results— Thirty-three patients were studied during (21 paroxysmal, 12 persistent)...
Background— Adenosine acutely reconnects pulmonary veins (PVs) after radiofrequency application, revealing “dormant conduction” and identifying PVs at risk of reconnection, but the underlying mechanisms are unknown. Methods Results— Canine PV left-atrial (LA) action potentials were recorded with standard microelectrodes ionic currents whole-cell patch clamp before adenosine perfusion. isolated current application in coronary-perfused LA-PV preparations. abbreviated potential duration...
Ablation of high-frequency sources in patients with atrial fibrillation (AF) is an effective therapy to restore sinus rhythm. However, this strategy may be ineffective without a significant dominant frequency (DF) gradient. The aim study was investigate whether sites activity human AF can identified noninvasively, which should help intervention planning and therapy.In 14 history AF, 67-lead body surface recordings were simultaneously registered 15 endocardial electrograms from both atria...
Some patients with an automatic implantable cardioverter-defibrillator (ICD) suffer multiple appropriate, consecutive, high-energy discharges (MCDs) during follow-up. Such events might represent resistant ventricular arrhythmias and have prognostic significance.Eighty consecutive ICD were followed up for to 82 months (mean, 21 +/- 19 months). Thirty-eight had survived out-of-hospital cardiac arrest 42 recurrent tachycardia. During follow-up, 16 MCD (group A), 26 episodes of single...
Three trials demonstrated recently that a long detection window reduces implantable cardioverter-defibrillator (ICD) therapy in primary prevention patients. Avoid Delivering Therapies for Nonsustained Arrhythmias ICD Patients III (ADVANCE III) was the only trial enrolled both and secondary patients.Of 1902 patients ADVANCE trial, 477 received defibrillator prevention; 248 were randomly assigned to setting (30 of 40 intervals) 229 nominal (18 24 ventricular arrhythmias with cycle length ≤ 320...
Background —The crista terminalis (CT) has been identified as the posterior boundary of typical atrial flutter (AFL) in lateral wall (LW) right atrium (RA). To study conduction properties across CT, rapid pacing was performed at both sides CT after bidirectional block achieved cavotricuspid isthmus by radiofrequency catheter ablation. Methods and Results —In 22 patients (aged 61±7 years) with AFL (cycle length, 234±23 ms), during double electrograms recorded between LW (PW). After ablation...
Ablation of high dominant frequency (DF) sources in patients with atrial fibrillation (AF) is an effective treatment option for paroxysmal AF. The aim this study was to evaluate the accuracy noninvasive estimation DF and electrical patterns determination by solving inverse problem electrocardiography.Four representative AF left-to-right right-to-left were included study. For each patient, intracardiac electrograms from both atria recorded simultaneously together 67-lead body surface...
Abstract Introduction Following myocardial infarction (MI), there is a high risk of sudden cardiac death due to the development ventricular tachycardia (VT). This study aimed evaluate effects intracoronary (IC) administration cardiosphere-derived cell secretome (S-CDCs) on VT inducibility and function in porcine model MI. Methods Fourteen pigs underwent endovascular MI induction. At four weeks, either saline (CON; 5 ml; n=7) or S-CDCs (9.16 mg protein ml saline; were blindly administered via...
The differential diagnosis of supraventricular tachycardia with concentric atrial activation usually requires the inducibility sustained and needs a complex time-consuming electrophysiological evaluation. To develop simple test to establish if ventriculoatrial conduction uses posteroseptal accessory pathway or normal system, we compared intervals during right ventricular pacing from apical posterobasal sites.Continuous was performed an site in 34 patients retrograde over system (group A) 22...