A5075107870- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- ECG Monitoring and Analysis
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Ion channel regulation and function
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Vagus Nerve Stimulation Research
- Spine and Intervertebral Disc Pathology
- RNA and protein synthesis mechanisms
- T-cell and Retrovirus Studies
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Heart Rate Variability and Autonomic Control
- Network Security and Intrusion Detection
- Pulmonary Hypertension Research and Treatments
- Ocular and Laser Science Research
- Telemedicine and Telehealth Implementation
Barts Health NHS Trust
2017-2025
St Bartholomew's Hospital
2016-2025
William Harvey Research Institute
2022-2025
Queen Mary University of London
2017-2025
British Heart Foundation
2017-2024
RELX Group (United States)
2024
RELX Group (United Kingdom)
2024
University of London
2023
National Health Service
2019-2023
Government of the United Kingdom
2019-2022
Abstract Background Pulmonary vein isolation (PVI) using high power delivered by SmartTouch Surround Flow (STSF) catheters guided ablation index (AI) was evaluated in a multicenter registry. Methods Patients with paroxysmal AF underwent PVI STSF 30 W on the posterior wall and 40 elsewhere. AI targets were 350 walls 450 Procedures compared controls conventionally irrigated contact force‐sensing conventional powers (25 elsewhere) force‐time integral (no agreed targets). The waiting period of...
This study sought to use a novel panoramic mapping system (CARTOFINDER) detect and characterize drivers in persistent atrial fibrillation (AF).Mechanisms sustaining AF remain uncertain.Patients undergoing catheter ablation for were included. A 64-pole basket was used acquire unipolar signals, which processed by the generate wavefront propagation maps. The identify potential pre- post-pulmonary vein (PV) isolation. effect of on identified post-PV isolation assessed.Twenty patients included...
The goal of this study was to develop a risk score model for patients with Brugada syndrome (BrS).Risk stratification in BrS is significant challenge due the low event rates and conflicting evidence.A multicenter international cohort no previous cardiac arrest used evaluate role 16 proposed clinical or electrocardiogram (ECG) markers predicting ventricular arrhythmias (VAs)/sudden death (SCD) during follow-up. Predictive were incorporated into model, validated by using out-of-sample...
Antimicrobial envelopes reduce the incidence of cardiac implantable electronic device infections, but their cost restricts routine use in United Kingdom. Risk scoring could help to identify which patients would most benefit from this technology.
The sympathetic autonomic nervous system plays a major role in arrhythmia development and maintenance. Historical preclinical studies describe preferential increases cardiac tone upon selective stimulation of the subclavian ansae (SA), nerve cord encircling artery. This study sought to define, for first time, functional anatomy physiology SA humans using percutaneous approach. authors prospectively recruited patients undergoing catheter ablation paroxysmal atrial fibrillation (AF) under...
ABSTRACT Background Exercise Oscillatory Ventilation (EOV) and a steep ventilatory efficiency (VE/VCO2) slope are features of inefficiency on cardiopulmonary exercise testing (CPET), both associated with poor prognosis in patients heart failure (HF). The prevalence co‐existent atrial fibrillation (AF) the impact catheter ablation (CA) is unknown. Objectives To characterize persistent AF Left Ventricular Systolic Dysfunction (LVSD) assess CA. Methods Patients Ejection Fraction (LVEF) < 50%...
Background Outcomes of catheter ablation atrial fibrillation (AF) are variable and the predictors success require further elucidation since identification correctable risk factors could help to optimize therapy. We aimed assess impact body mass index (BMI) in overall safety efficacy AF, with emphasis on use cryoballoon novel oral anticoagulants. Methods Results There were 2497 consecutive patients undergoing AF 7 European high volume centers stratified according BMI (normal weight <25 kg/m2,...
Rate-dependent conduction velocity (CV) slowing is associated with atrial fibrillation (AF) initiation and reentrant mechanisms.The purpose of this study was to assess the relationship between bipolar voltage, CV dynamics, AF drivers.Patients undergoing catheter ablation for persistent (<24 months) were enrolled. Unipolar electrograms recorded a 64-pole basket during pacing at 4 intervals (PIs) sinus rhythm. CVs measured pole pairs along wavefront path correlated underlying voltage. dynamics...
The aim of this study was to demonstrate that a stochastic vector-based mapping approach could guide ablation atrial fibrillation (AF) drivers as evidenced by response and long-term follow-up outcomes. optimal method for AF is yet be defined. Patients undergoing persistent were recruited. underwent pulmonary vein isolation (PVI) with further guided the trajectory analysis ranked signals (STAR) method. proportion time an electrode’s activation seen precede its neighboring electrodes used...
The RADIANCE first-in-man study evaluated acute (3-month) safety and design concept in terms of utility a new multi-electrode radiofrequency (RF) balloon catheter (HELIOSTAR, Biosense Webster) to achieve pulmonary vein isolation (PVI). After conclusion, subset patients was followed up 12 months.Patients with drug refractory paroxysmal atrial fibrillation were enrolled. Neurological assessment, cardiac cerebral magnetic resonance imagings performed pre post procedure. Ablation delivered at 15...
Abstract Aims To define the clinical characteristics and long-term outcomes of a large cohort patients with idiopathic ventricular fibrillation (IVF) normal 12-lead electrocardiograms (ECGs). Methods results Patients as presenting rhythm, baseline, follow-up ECGs no signs cardiac channelopathy including early repolarization or atrioventricular conduction abnormalities, without structural heart disease were included in registry. A total 245 (median age: 38 years; males 59%) recruited from 25...
Abstract Introduction Cryoballoon ablation is an established technique to achieve pulmonary vein isolation in patients with atrial fibrillation (AF). Recently, a new manufacturer of cryoballoon achieved regulatory CE marking (POLARx™; Boston Scientific). We describe our early experience using this market entrant the technology and procedural aspects comparison incumbent Medtronic Arctic Front Advance™. Methods assessed first 40 AF ablations performed POLARx catheter at Barts Heart Centre....
Abstract Aims The SMART Pass™ (SP) algorithm is a high-pass filter that aims to reduce inappropriate therapy (IT) in subcutaneous internal cardiac defibrillator (S-ICD), but SP can deactivate due low amplitude sensed R waves or asystole. association between IT and deactivation management strategies were evaluated, hypothesizing increases the risk of device re-programming, lead/generator re-positioning could this risk. Methods results Retrospective single-centre audit Emblem™ S-ICD devices...
Abstract Introduction Identifying drivers in persistent atrial fibrillation (AF) remains challenging. We sought to validate an automated system for detection of focal activation using basket and PentaRay catheters AF. Methods Patients having ablation tachycardia (AT) AF were mapped. Thirty‐second unipolar recordings analyzed CARTOFINDER. Focal or “region interest” (ROI) was defined as more than equal 2 consecutive activations with one electrode leading relative its neighbors QS morphology on...
Human T-lymphotropic virus type 1 (HTLV-1), a retrovirus, is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia/lymphoma (ATLL). The reported association with pulmonary disease such as bronchiectasis less certain.A retrospective case review HTLV-1 seropositive cohort attending national referral centre. was categorised into symptomatic patients (SPs) (ATLL, HAM/TSP, Strongyloidiasis HTLV associated inflammatory (HAID))...