A5080602807- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Electrochemical Analysis and Applications
- Cardiac Arrest and Resuscitation
- Electrical and Bioimpedance Tomography
- Pulmonary Hypertension Research and Treatments
- Fault Detection and Control Systems
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Sports injuries and prevention
Queen Mary University of London
2023-2024
University of Leicester
2019-2022
Introduction The mechanism, frequency and clinical impact of arrhythmias in pulmonary hypertension (PH) are unclear. We sought to clarify the electrophysiological mechanism PH correlate with arrhythmia incidence outcomes. Methods Invasive (n=10) non-invasive (n=30) mapping techniques determined myocardial conduction velocity, scar burden atrioventricular (AV) nodal refractoriness, which were then related cardiac structure function. Implantable monitors (ICMs) implanted into 80 patients...
To enable large in silico trials and personalized model predictions on clinical timescales, it is imperative that models can be constructed quickly reproducibly. First, we aimed to overcome the challenges of constructing cardiac at scale through developing a robust, open-source pipeline for bilayer volumetric atrial models. Second, investigate effects fibres, fibrosis representation fibrillatory dynamics. construct models, extended our previously developed coordinate system incorporate...
Background Areas of abnormal and/or heterogenous conduction velocity (CV) are important ablation targets for ventricular tachycardias. Yet, precise assessment CV in clinical contact mapping remains challenging. Numerous different estimation methods have been proposed. Objective To compare the automated LAT-independent omnipolar-based method termed "Wave Speed" (WS) with four established LAT-based and formally establish quantitative differences between them. Methods High-density maps patients...
Abstract Background Identification of functionally critical sites to target for ablation in scar-related VT during substrate mapping remains challenging. Vector Field Heterogeneity (VFH) is a novel omnipolar metric quantify locally heterogeneous propagation patterns. Objective Assess the diagnostic value VFH characterizing abnormal patterns ventricular and compare between isthmus, low voltage bystander areas (LVA) normal (NVA). Methods High-density maps activation acquired with 16-pole grid...
Abstract This study presents an electrocardiogram (ECG) monitoring and processing system which can observe subjects in real time display the resultant ECG signals on a computer for observation. The primary application is remote observation of cardiac patients. paper aims to determine its reliability by analysing portability wireless connectivity. comprised three principal units, namely data acquisition circuit, where electrical are detected using surface electrodes placed at different...
Abstract Background ACM is a hereditary condition characterized by fibrofatty infiltration and replacement of cardiac myocytes predominantly presenting with ventricular arrhythmias (VA). Cardiac imaging allows for detailed structural phenotyping scar patterns in ACM. Yet, there lack tools to objectively quantify the electrical substrate alterations that may enable more precise identification critical sites predispose VA. Purpose To locally disorganized propagation wavefronts using Vector...
Abstract Funding Acknowledgements This work was supported by the NIHR Leicester Biomedical Research Centre. XL funded MRC(MR/S037306/1) and BHF (PG/18/33/33780) Background It remains controversial as to whether rotors detected using phase mapping during persistent atrial fibrillation (persAF) represent main drivers of underlying mechanism others found be located near line conduction block. Regional electrogram desynchronization (RED) has been suggested successful targets for persAF ablation,...
Understanding the spatiotemporal behaviour of 'rotors' in human atrial fibrillation (AF) is important for using them as targets ablation.This study aims to track stability rotors over 5 min time interval during persistent (PersAF).This involved 10 PersAF patients, who underwent catheter ablation.2048 non-contact virtual unipolar electrograms (VEGMs) were simultaneously collected and resampled at 512Hz, QRST removed reconstructed a sinusoidal wavelet fitting approach (Kuklik et al.Subsequent...
Purpose: Several studies have emphasised the significance of high dominant frequency (HDF) and rotors in perpetuation AF. However, co-localisation relationship between both attributes is not completely understood yet. In this study, we aim to evaluate spatial distributions HDF regions rotor sites within left atrium (LA) pre post HDF-guided ablation PersAF. Methods: This study involved 10 PersAF patients undergoing catheter targeting LA. 2048-channels atrial electrograms (AEG) were collected...
Understanding the spatiotemporal behaviour of ‘rotors’ in human atrial fibrillation (AF) is important for using them as targets ablation. This study aims to track stability rotors over 5 min time interval during persistent (PersAF). involved 10 PersAF patients, who underwent catheter 2048 non-contact virtual unipolar electrograms (VEGMs) were simultaneously collected and resampled at 512Hz, QRST removed reconstructed a sinusoidal wavelet fitting approach (Kuklik et al. Subsequent density...
To better understand the propagation of electrical activity Atrial Fibrillation (AF) in Left Atrium (LA), is essential for AF termination and treatment (catheter ablation). Components 3 computing models were combined, they were: Fenton & Karma, Courtemanche et al. Simitev-Biktashev. It aims to follow spread simulation form LA be generalisable, using a larger set parameters, achieved by combining models. Potentially, enabling degree efficiency trailing an individualised manner each patient....
To better understand the propagation of electrical activity Atrial Fibrillation (AF) in Left Atrium (LA), is essential for AF termination and treatment (catheter ablation).Components 3 computing models were combined, they were: Fenton & Karma, Courtemanche et al. Simitev-Biktashev.It aims to follow spread simulation form LA be generalisable, using a larger set parameters, achieved by combining models.Potentially, enabling degree efficiency trailing an individualised manner each...
Sequential electrogram collection using multipolar catheters (Pantaray, HD Grid, etc.) is increasingly used in persistent atrial fibrillation (persAF) mapping.However, it unknown whether sequential mapping suitable for dominant frequency (DF) mapping, as DF tends to be spatiotemporally unstable.We aim model and compare simultaneously sequentially collected EGMs mapping.
Identifying ablation targets in persistent atrial fibrillation (PersAF) remains challenging. This study aims to investigate the spatiotemporal stability of PersAF drivers within 5 min recordings virtual electrograms (VEGMs). 2048-channel VEGMs (EnSite Array, Abbott) were analysed for patients undergoing substrate-guided ablation. Following QRST subtraction, dominant frequency (DF, 4–10 Hz) and organization index (OI) identified using fast Fourier transform (4 s windows; 50% overlap). Areas...
The combined use of dominant frequency (DF) and organization index (OI) might help to identify atrial regions with organized, fast activation rates in persistent fibrillation (persAF). We determined adaptive thresholds for DF OI based on electrophysiological responses following AF substrate modification. 2048-channel electrograms (3206 EGMs, 30 s, EnSite Array) were analyzed from 10 persAF patients undergoing DF-guided ablation. After QRST subtraction, Fourier transform was used calculate...