A5025530610- Glioma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Cannabis and Cannabinoid Research
- Vascular Malformations Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Moyamoya disease diagnosis and treatment
- Cytomegalovirus and herpesvirus research
- Vasculitis and related conditions
- Genetics and Neurodevelopmental Disorders
- Head and Neck Surgical Oncology
- Sarcoma Diagnosis and Treatment
- Brain Metastases and Treatment
- Autoimmune and Inflammatory Disorders Research
- Protein Tyrosine Phosphatases
- Prenatal Screening and Diagnostics
- Hedgehog Signaling Pathway Studies
- Neurological and metabolic disorders
- Genomics and Rare Diseases
- Polyomavirus and related diseases
- Mast cells and histamine
- Kidney Stones and Urolithiasis Treatments
- Hearing, Cochlea, Tinnitus, Genetics
University of Chieti-Pescara
2020-2023
Federico II University Hospital
2013-2022
Don Carlo Gnocchi Foundation
2014-2022
Merck Serono (Italy)
2022
University of Naples Federico II
2010-2021
University of Campania "Luigi Vanvitelli"
2019
Fatebenefratelli Hospital
2019
Tecnologie Avanzate (Italy)
2017
Institute of Neurobiology and Molecular Medicine
2016
Istituti di Ricovero e Cura a Carattere Scientifico
2014
Traditional use and clinical reports suggest that the culinary herb sage (<i>Salvia officinalis</i>) may be effective for patients with mild to moderate Alzheimer9s disease (AD). In this study, we evaluated effect of a standardized extract from leaves <i>S. officinalis</i> (SOE) its active ingredient rosmarinic acid on Alzheimer amyloid-β peptide (Aβ)-induced toxicity in cultured rat pheochromocytoma (PC12) cells. Incubation PC12 cells Aβ (fragment 1–42) 24 h caused cell death, was reduced...
Importance Although whole-body hypothermia is widely used after mild neonatal hypoxic-ischemic encephalopathy (HIE), safety and efficacy have not been evaluated in randomized clinical trials (RCTs), to our knowledge. Objective To examine the effect of 48 72 hours HIE on cerebral magnetic resonance (MR) biomarkers. Design, Setting, Participants This open-label, 3-arm RCT was conducted between October 31, 2019, April 28, 2023, with masked outcome analysis. were neonates at 6 tertiary intensive...
To cite this article: Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno De Filippis D, D’Amico A, Saturnino C, Orlando P, Zimmer Iuvone Di Marzo V. Protective role of palmitoylethanolamide in contact allergic dermatitis. Allergy 2010; 65 : 698–711. Abstract Background: Palmitoylethanolamide (PEA) is an anti‐inflammatory mediator that enhances the activation by anandamide (AEA) cannabinoid receptors and transient receptor potential vanilloid type‐1 (TRPV1) channels,...
Abstract Purpose Pituitary macroadenoma consistency can influence the ease of lesion removal during surgery, especially when using a transsphenoidal approach. Unfortunately, it is not assessable on standard qualitative MRI. Radiomic texture analysis could help in extracting mineable quantitative tissue characteristics. We aimed to assess accuracy combined with machine learning preoperative evaluation pituitary patients undergoing endoscopic endonasal surgery. Methods Data 89 (68 soft and 21...
The endocannabinoid system plays protective roles against the growth and spreading of several types carcinomas. Because estrogens regulate this both in physiological states cancer, paper we evaluated its involvement endometrial carcinoma, a well-known estrogen-dependent tumor. To test whether is expressed tissue samples were collected from 18 patients undergoing surgical treatment for adenocarcinoma 16 healthy age-matched controls, treated Western blot immunohistochemical analysis. Moreover,...
Sepsis is an inflammatory condition that associated with reduced propulsive gastrointestinal motility (ileus). A therapeutic option to treat sepsis promote intestinal propulsion preventing bacterial stasis, overgrowth and translocation. Recent evidence suggests anti-oxidants improve sepsis-induced ileus. Cannabidiol, a non-psychotropic component of Cannabis sativa, exerts strong anti-oxidant anti-inflammatory effects without binding cannabinoid CB(1) or CB(2) receptors. Cannabidiol also...
Abstract A statistical study was done on the sensorineural component in hearing loss, using 595 patients suffering from Chronic Otitis Media (COM); of these, 195 with monolateral COM were taken into consideration. They presented criteria valuation which excluded other possible causes such as exposure to acoustic trauma, ototoxic drugs, cardiovascular disease, past head injury and hereditary causes. The contralateral (healthy) ear served a control. We determined average losses relation age...
Background. The growing social emergency represented by Alzheimer’s disease (AD) and the lack of medical treatments able to modify course have kindled interest in nonpharmacological therapies. Objective. We introduced a novel approach for people with AD (PWA) named Multidimensional Stimulation group Therapy (MST) improve PWA condition different domains: cognition, behavior, motor functioning. Methods. Enrolling 60 mild moderate stage disease, we evaluated efficacy MST randomized-controlled...
Oral-facial-digital type 1 syndrome (OFD1; OMIM 311200) belongs to the expanding group of disorders ascribed ciliary dysfunction. With aim contributing understanding role primary cilia in central nervous system (CNS), we performed a thorough characterization CNS involvement observed this disorder. A cohort 117 molecularly diagnosed OFD I patients was screened for presence neurological symptoms and/or cognitive/behavioral abnormalities on basis available information supplied by collaborating...
Moyamoya syndrome (MMS) is the most common cerebral vasculopathy among children with neurofibromatosis type 1 (NF1). In this study, we clinically, radiologically, and genetically examined a cohort that was not previously described, comprising European NF1 MMS. The genotyping had been registered. This study included 18 children. mean age 2.93 ± 3.03 years at diagnosis 7.43 4.27 MMS diagnosis. seven patients, diagnosed before or same time as NF1. Neuroimaging performed in 10 patients due to...
The aim of the current study is to investigate integrity Mirror Neurons (MN) network in normal aging, Mild Cognitive Impairment (MCI), and Alzheimer disease (AD). Although AD MCI are considered "cognitive" diseases, there has been increasing recognition a link between motor function AD. More recently embodied cognition hypothesis also developed: it postulates that part results from coupling action perception representations. MN represent neuronal population which links perception, action,...
Mutations in KARS, which encodes for both mitochondrial and cytoplasmic lysyl-tRNA synthetase, have been so far associated with three different phenotypes: the recessive form of Charcot-Mary-Tooth polyneuropathy, autosomal nonsyndromic hearing loss last recently described condition related to congenital visual impairment progressive microcephaly. Here we report case a 14-year-old girl severe cardiomyopathy mild psychomotor delay myopathy; moreover, diffuse reduction cytochrome C oxidase...
Palmitoylethanolamide (PEA) and some of its analogues have shown great efficacy in the treatment pain inflammation. Adelmidrol - International Nonproprietary Name (INN) di-amide derivative azelaic acid is one these analogues. The anti-inflammatory analgesic effects PEA adelmidrol are hypothesized to be mediated, at least part, by mast cell down-modulation. Mast mediators released early stage inflammatory process drive reaction chronicity as it happens X-carrageenin-induced granulomatous...
Neurofibromas are the hallmark lesions in Neurofibromatosis 1 (NF1); these tumors classified as cutaneous, subcutaneous and plexiform. In contrast to cutaneous neurofibromas, plexiform neurofibromas can grow quickly progress malignancy. Curcumin, a turmeric-derived polyphenol, has been shown interact with several molecular targets implicated carcinogenesis. Here, we describe impact of different dietary patterns, namely Mediterranean diet (MedDiet) compared Western (WesDiet), both or without...
The accurate stratification of infants with congenital cytomegalovirus (CMV) infection at risk for more severe outcome may help in the management patients. Aim this study was to investigate ability a comprehensive neuroimaging investigation predicting long-term neurodevelopmental patients CMV. We analyzed prognostic accuracy traditional score and recently proposed scale applied head ultrasound (HUS), computed tomography (CT) magnetic resonance imaging (MRI).All consecutive neonates born from...
Increasing evidence suggests that non-pharmacological therapies impact on neuropsychiatric symptoms and quality of life in people with Alzheimer's disease. Among these, art-based interventions seem particularly suitable for elders' rehabilitation as they act both cognitive functions life. However, their benefits are not yet appropriately explored. The main aim this quasi-experimental study was to test the feasibility likely efficacy a novel multi-dimensional visual art intervention disease...