A5064533816- Telomeres, Telomerase, and Senescence
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Metabolism and Genetic Disorders
- Tissue Engineering and Regenerative Medicine
- Mitochondrial Function and Pathology
- Bone Tissue Engineering Materials
- Adipose Tissue and Metabolism
- Blood properties and coagulation
- Cancer, Hypoxia, and Metabolism
- Genetic Neurodegenerative Diseases
- Polymer Surface Interaction Studies
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Muscle Physiology and Disorders
- Sperm and Testicular Function
- Hydrogels: synthesis, properties, applications
- 3D Printing in Biomedical Research
- biodegradable polymer synthesis and properties
- Urologic and reproductive health conditions
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- Cancer-related Molecular Pathways
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
National Research Council
2016-2025
Saint Camillus International University of Health and Medical Sciences
2022-2025
University of Palermo
2024
Institute of Biosciences and Bioresources
2013-2022
Institute of Ecosystem Study
2019-2021
Terrestrial Ecosystem Research Network
2020
Institute of Agricultural Biology and Biotechnology
2017-2018
University of Naples Federico II
1999-2016
University of Campania "Luigi Vanvitelli"
2002-2016
Erciyes University
2016
Senescent cells secrete senescence-associated secretory phenotype (SASP) proteins to carry out several functions, such as sensitizing surrounding senesce; immunomodulation; impairing or fostering cancer growth; and promoting tissue development. Identifying secreted factors that achieve tasks is a challenging issue since the profile of depends on genotoxic stress cell type. Currently, researchers are trying identify common markers for SASP. The present investigation compared secretome...
Cellular senescence is the permanent arrest of cell cycle, physiologically related to aging and aging-associated diseases. Senescence also recognized as a mechanism for limiting regenerative potential stem cells protect from cancer development. The program realized through autocrine/paracrine pathways based on activation peculiar senescence-associated secretory phenotype (SASP). We show here that conditioned media (CM) senescent mesenchymal (MSCs) contain set secreted factors are able induce...
// Nicola Alessio 2 , Stefania Del Gaudio Capasso Giovanni Di Bernardo Salvatore Cappabianca 4 Marilena Cipollaro Gianfranco Peluso 3 Umberto Galderisi 1, 2, 1 Sbarro Institute for Cancer Research and Molecular Medicine, Center Biotechnology, Temple University, Philadelphia, PA 19107-6799, USA Department of Experimental Biotechnology Biology Section, Second University Naples, Naples 80138, Italy Bioscience Bioresources, CNR, “F. Magrassi – A. Lanzara” Correspondence to:...
The metabolic alterations of cancer cells represent an opportunity for developing selective antineoplastic treatments. We investigated the therapeutic potential ST1326, inhibitor carnitine-palmitoyl transferase 1A (CPT1A), rate-limiting enzyme fatty acid (FA) import into mitochondria.ST1326 was tested on in vitro and vivo models Burkitt's lymphoma, which c-myc, drives cellular demand FA metabolism, is highly overexpressed. performed assays to evaluate effect ST1326 proliferation, oxidation,...
// Stefania Capasso 2 , Nicola Alessio Tiziana Squillaro Giovanni Di Bernardo Mariarosa A. Melone 3,4 Marilena Cipollaro Gianfranco Peluso 3 and Umberto Galderisi 1,2,3 1 Sbarro Institute for Cancer Research Molecular Medicine, Center Biotechnology, Temple University, Philadelphia, PA, USA Department of Experimental Biotechnology Biology Section, Second University Naples, Italy Bioscience Bioresources, CNR, 4 Clinical Medicine Surgery, Division Neurology, Correspondence to: Peluso, email:...
During their life span, cells have two possible states: a non-cycling, quiescent state (G0) and cycling, activated state. Cells may enter reversible G0 of quiescence or, alternatively, they undergo an irreversible The latter be physiological differentiation following stress event, senescent status. Discrimination among the several states represents significant investigation, since quiescence, differentiation, senescence are progressive phenomena with intermediate transitional stages. We used...
The concept of "stemness" incorporates the molecular mechanisms that regulate unlimited self-regenerative potential typical undifferentiated primitive cells. These cells possess unique ability to navigate cell cycle, transitioning in and out quiescent G0 phase, hold capacity generate diverse phenotypes. Stem cells, as precursors endow with extraordinary regenerative capabilities, exhibit a heterogeneous tissue-specific distribution throughout human body. identification characterization...
Abstract Cells that are exposed to harmful genetic damage, either from internal or external sources, may undergo senescence if they unable repair their DNA. Senescence, characterized by a state of irreversible growth arrest, can spread neighboring cells through process known as the senescence-associated secretory phenotype (SASP). This phenomenon contributes both aging and development cancer. The SASP comprises variety factors regulate numerous functions, including induction secondary...
Skeletal muscle in congestive heart failure is responsible for increased fatigability and decreased exercise capacity. A specific myopathy with expression of fast-type myosins, myocyte atrophy, secondary to apoptosis triggered by high levels circulating tumor necrosis factor-alpha (TNF-alpha) has been described. In an animal model failure, the monocrotaline-treated rat, we have observed increase apoptotic skeletal nuclei. Proapoptotic agents, caspase-3 -9, were increased, as well serum...