A5081519754- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Sarcoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Multiple Myeloma Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurofibromatosis and Schwannoma Cases
- Sinusitis and nasal conditions
- Salivary Gland Tumors Diagnosis and Treatment
- Allergic Rhinitis and Sensitization
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Alzheimer's disease research and treatments
- Thyroid and Parathyroid Surgery
- Oral and Maxillofacial Pathology
- Pituitary Gland Disorders and Treatments
- Medical Imaging and Pathology Studies
- Ovarian cancer diagnosis and treatment
- PI3K/AKT/mTOR signaling in cancer
- Cardiac tumors and thrombi
- Ear and Head Tumors
- Cancer Diagnosis and Treatment
University of Foggia
2020-2024
University of Bari Aldo Moro
2019-2020
Microglia activation drives the pro-inflammatory activity in early stages of Alzheimer's disease (AD). However, mechanistic basis is elusive, and hypothesis targeting microglia to prevent AD onset little explored. Here, we demonstrated that upon LPS exposure, shift towards an energetic phenotype characterised by high glycolysis mitochondrial respiration with dysfunction. Although electron transport chain (ETC) complexes boosted LPS, this mostly devoted generation reactive oxygen species. We...
Monocytes (Mos) are crucial in the evolution of metabolic dysfunction-associated steatotic liver disease (MASLD) to steatohepatitis (MASH), and immunometabolism studies have recently suggested targeting leukocyte bioenergetics inflammatory diseases. Here, we reveal a peculiar bioenergetic phenotype circulating Mos patients with MASH, characterized by high levels glycolysis mitochondrial (mt) respiration. The enhancement mt respiratory chain activity, especially complex II (succinate...
Epidermal growth factor receptor (EGFR) and its ligand heparin-binding EGF-like (HB-EGF) sustain endothelial cell proliferation angiogenesis in solid tumors, but little is known about the role of HB-EGF-EGFR signaling bone marrow multiple myeloma (MM) progression. We found that cells from patients with MM express high levels EGFR HB-EGF, compared monoclonal gammopathy undetermined significance, overexpressed HB-EGF stimulates expression an autocrine loop. also parallel plasma number, a...
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of globally, and represents a health care burden as treatment options are very scarce. The reason behind NAFLD progression to non-alcoholic steatohepatitis (NASH) not completely understood. Recently, deficiency micronutrients (e.g., vitamins, minerals, other elements) has been suggested crucial in progression, such that recent studies reported potential hepatic antioxidant properties supplementation. However, little known. Here...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is defined as a Type 2 eosinophilic disease, while CRSsNP considered 1 neutrophilic disease. Since neutrophils are also activated in CRSwNP, the eosinophil-neutrophil dualism has been revaluated. Among inflammatory cells infiltrating sinus-nasal tissues, role of mast (MCs) not already recognized, although Clinical-Cytological Grading, which defines severity attributes to mixed eosinophil-MC forms CRSwNP greater risk recurrence. We aimed...
Background. The acinic cell carcinoma (AciCC) of the parotid gland is a rare tumor with an indolent behavior; however, subgroup this presents aggressive behavior tendency to recur. aim multicenter study was identify and stratify those patients AciCC at high risk recurrence. Methods. A retrospective carried out involving 77 treated surgery between January 2000 September 2022, in different Italian referral centers. Data about characteristics its recurrence were collected. histological...
Primary pulmonary enteric adenocarcinoma (PEAC) is a rare non-small cell lung cancer subtype sharing morphologic and immunohistochemical features with colorectal adenocarcinoma. Given the frequency of metastases in cancer, differential diagnosis PEAC according to routine morphological findings may be difficult. Genome sequence by next-generation sequencing has recently introduced new perspectives better define tumor sensitivity treatments, while rarity this still limits current knowledge its...
Benign recurrent intrahepatic cholestasis is a genetic disorder with cholestatic jaundice due to ATP8B1 and ABCB11 gene mutations encoding for hepato-canalicular transporters. Herein, we firstly provide the evidence that nonsense variant of (c.1558A>T) in heterozygous form involved BRIC pathogenesis.A 29-year-old male showed severe laboratory tests consistent despite normal gamma-glutamyltranspeptidase. Acute chronic liver diseases viral, metabolic autoimmune etiology were excluded. Normal...
Innovative therapies have improved the overall survival in melanoma, although a high number of patients still experience disease progression or recurrence. Ex-vivo culture circulating tumour cells (CTCs) represents valuable laboratory resource for in-depth characterization rare cell populations responsible progression.CTCs from with metastatic melanoma were in-vitro established. Their stemness was demonstrated by both phenotypic and genotypic assays, as well functional studies. Xenograft...
Solitary fibrous tumor of the liver (SFTL) is a rare occurrence with low number cases reported in literature. SFTL usually benign but, 10%-20% are to be malignant tendency metastasize. The majority associated paraneoplastic hypoglycaemia defined as Doege-Potter syndrome. Surgery best therapeutic treatment, however, long- life follow-up recommended.A 74-year-old man, was admitted emergency department after syncopal episode detection resistant medical treatment. computed tomography revealed...
DEAD-Box Helicase 4 (Ddx4)+ ovarian stem cells are able to differentiate into several cell types under appropriate stimuli. Ddx4 expression has been correlated with poor prognosis of serous cancer (OC), while the potential role Ddx4+ in non-serous epithelial OC (NS-EOC) is almost unexplored. The aim this study was demonstrate presence NS-EOC and investigate effect follicle-stimulating hormone (FSH) on population. Increased demonstrated samples from patients advanced NS-EOC, compared those...
Event Abstract Back to Diffuse epithelioid angiosarcoma of the oral cavity: clinical, radiological and immunohistochemical presentation a case Fedora Della Vella1*, Paolo Callea1, Claudia Laudadio1, Eliano Cascardi1, Loren Duda1 Massimo Petruzzi1 1 University Bari Aldo Moro, Interdisciplinary Department Medicine, Italy Aim. Angiosarcomas are extremely rare tumors arising in vascular endothelium. They comprise only 1-2% soft tissues sarcomas usually occur skin subcutis, or visceral sites such...