A5050009953- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Advanced Chemical Sensor Technologies
- Respiratory and Cough-Related Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Olfactory and Sensory Function Studies
- Dysphagia Assessment and Management
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
- Gas Sensing Nanomaterials and Sensors
- Insect Pheromone Research and Control
- Gastroesophageal reflux and treatments
- Vitamin D Research Studies
- Cardiovascular and Diving-Related Complications
- Cystic Fibrosis Research Advances
- IL-33, ST2, and ILC Pathways
- Sinusitis and nasal conditions
- Sleep and Wakefulness Research
University of Bari Aldo Moro
2013-2025
Ospedale Civile di Venezia
2018-2024
University of Ioannina
2022
Second Affiliated Hospital of Luohe Medical College
2020
Abstract Purpose Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world in grip Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm associated severity. consideration role vitamin immune system, aim this study was to analyse levels patients acute failure due COVID-19 and assess any correlations severity prognosis. Methods retrospective, observational study, we analysed demographic, clinical...
Obstructive Sleep Apnea (OSA) is a sleep-related breathing disorder associated with the development of cardiovascular diseases and atherosclerosis. Systemic inflammation plays an important role in complications OSA patients. The aim study was to evaluate relationship between carotid intima-media thickness (cIMT) inflammatory markers plasma levels We enrolled 80 patients 40 controls matched for age body mass index (BMI). presence severity sleep apnea determined by in-laboratory portable...
Abstract Purpose: Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world in grip Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm associated severity. consideration role vitamin immune system, aim this study was to analyse levels patients acute failure due COVID-19 and assess any correlations severity prognosis. Methods: retrospective, observational study, we analysed demographic,...
The aim of our study was to assess whether a polymer-based e-nose can distinguish head and neck cancer subjects from healthy controls, as well patients with allergic rhinitis. A total number 45 participated in this study. first group composed 15 histology confirmed diagnosis cancer. second made up diagnoses control consisted negative history upper airways and/or chest symptoms. Exhaled breath collected all participants sampled by (Cyranose 320, Sensigent, Pasadena, CA, USA). In the Principal...
Background: Laryngopharyngeal reflux (LPR) is a common inflammatory condition of the upper aerodigestive tract tissues related to effects gastroduodenal content reflux, characterized by wide variety clinical manifestations. The aim our study was evaluate possible association between dental disorders and LRP, focusing on role salivary changes. Methods: Patient's status evaluated according Schiff Index Sensitivity Scale (SISS), Basic Erosive Wear Examination (BEWE) Decayed, Missing, Filled...
In obese subjects with obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) may be linked to systemic and adipose tissue inflammation.We obtained abdominal subcutaneous biopsies from OSA non-OSA (BMI > 35) at baseline after 24 weeks (T1) of weight-loss intervention plus continuous positive airway pressure (c-PAP) or alone, respectively. were grouped according good (therapeutic) poor (subtherapeutic) adherence c-PAP.At baseline, anthropometric metabolic parameters, serum...
Abstract Hospitalized COVID-19 patients are vulnerable to different degrees of stress disorders as well depression, anxiety and fear. The aim this study was evaluate the feasibility introducing Music therapy on site with Covid-19 investigating immediate effects a single session has anxiety, heart rate (HR), oxygen saturation (O2Sat) satisfaction compared standard care. A randomized controlled trial 40 conducted. Participants were assigned control group (CG) or treatment (MG). MG received an...
Abstract Purpose Positive airway pressure (PAP) treatment for obstructive sleep apnea syndrome (OSAS) is often burdened by lower adherence rates. Patients’ perception and acceptance of PAP therapy play a crucial role in achieving acceptable adherence. Method We conducted prospective cohort study to assess patients’ initial impressions using six-item questionnaire. The questionnaire evaluated CPAP tolerance, interface comfort, titration pressure, likelihood use, expected health benefits,...
Exhaled breath contains thousands of volatile organic compounds (VOCs) in gaseous form, which may be used as markers airway inflammation and lung disease. Electronic noses enable quick real-time pattern analysis VOC spectra. It has been shown that the exhaled patients with obstructive sleep apnoea (OSA) differs from non-obese controls. We aimed to assess influence obesity composition VOCs by comparing obese subjects without OSA. Moreover, we identify discriminant two groups.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of central and peripheral motor neurons. Some studies have found discordant data in presence sleep apnea ALS patients. An obstructive component also occurs with upper airways hypotonia muscle weakness that may result an excessive reduction airway lumen, leading to (OSA). The aim this study was assess role apneic events at onset prognosis.A longitudinal retrospective conducted on 42...
BackgroundBiological therapies, such as mepolizumab, have transformed the treatment of severe eosinophilic asthma. Although mepolizumab's short-term effectiveness is established, there limited evidence on its ability to achieve long-term clinical remission.ObjectiveTo evaluate and safety explore potential induce sustained remission, identify baseline factors associated with likelihood achieving remission over 24 months.MethodsThe REMIssion in Severe Eosinophilic Asthma Treated Mepolizumab...
We aimed to investigate the effects of age and gender on profile exhaled volatile organic compounds. evaluated 68 healthy adult never-smokers, comparing them by gender. Exhaled breath samples were analyzed an electronic nose (e-nose), resulting in "breathprints". Principal component analysis canonical discriminant showed that older subjects (≥ 50 years age) could not be distinguished from younger basis their breathprints, as well breathprints males those females (cross-validated accuracy,...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is defined as a Type 2 eosinophilic disease, while CRSsNP considered 1 neutrophilic disease. Since neutrophils are also activated in CRSwNP, the eosinophil-neutrophil dualism has been revaluated. Among inflammatory cells infiltrating sinus-nasal tissues, role of mast (MCs) not already recognized, although Clinical-Cytological Grading, which defines severity attributes to mixed eosinophil-MC forms CRSwNP greater risk recurrence. We aimed...
Exhaled breath analysis using an e-nose is a groundbreaking tool for exhaled volatile organic compound (VOC) analysis, which has already shown its applicability in several respiratory and systemic diseases. It still unclear whether food intake can be considered confounder when analyzing the VOC-profile. We aimed to assess discriminate before after predefined at different time periods. enrolled 28 healthy non-smoking adults collected their as follows: (a) intake, (b) within 5 min consumption,...
Long COVID is now recognized as a common consequence of the SARS-CoV-2 infection, but we are still far from fully understanding its pathogenesis and predictive factors. Many pathophysiological factors have been studied, including ethnicity. To our knowledge, risk for not studied in Southeastern Italy.
Background/Objectives: Several studies have demonstrated the positive clinical and functional impact of adding Long-Acting Muscarinic Antagonist (LAMA) to Inhaled Corticosteroids (ICS) Beta-Agonists (LABA) therapy in treatment severe asthma. Aim objectives: To demonstrate that treating Small Airways Disease (SAD) asthma patients who are candidates for biologics can improve respiratory symptoms, lung function, airways inflammation, potentially avoiding or delaying use biological therapy....
<h3>BACKGROUND:</h3> CPAP is currently the treatment of choice for obstructive sleep apnea syndrome, but therapy adherence poor. Many educational trials have been proposed to increase adherence. We tested hypothesis that polysomnograph chart viewing by patients would improve <h3>METHODS:</h3> A controlled parallel group study was performed with 206 newly diagnosed syndrome patients, randomized into 2 groups (<i>n</i> = 103 each): standard support group, and group. Each subject viewed...
The analysis of volatile organic compounds (VOCs) by an electronic nose (e-nose) is a groundbreaking method that provides distinct exhaled molecular patterns in several respiratory and systemic diseases. It has been shown e-nose can detect obstructive sleep apnea (OSA) as well chronic pulmonary disease (COPD). OSA COPD are sometimes associated into the so-called overlap syndrome (OVS). In this pilot study we hypothesized could discriminate breath patients with OVS from subjects alone....