A5024276000- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neutrino Physics Research
- Cystic Fibrosis Research Advances
- Ultrasound in Clinical Applications
- Particle physics theoretical and experimental studies
- Astrophysics and Cosmic Phenomena
- Eosinophilic Esophagitis
- Obstructive Sleep Apnea Research
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Pediatric health and respiratory diseases
- Pleural and Pulmonary Diseases
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Extracellular vesicles in disease
- Neuroscience of respiration and sleep
- Lung Cancer Diagnosis and Treatment
- Allergic Rhinitis and Sensitization
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
University of Foggia
2016-2025
Ospedali Riuniti di Foggia
2020-2025
Weatherford College
2021
Hospital Clínic de Barcelona
2016-2020
Austral University
2020
Consejo Nacional de Investigaciones Científicas y Técnicas
2020
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2019
Universitat de Barcelona
2019
Fundació Clínic per a la Recerca Biomèdica
2015
The efficacy of dupilumab as biological treatment severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) depends on its ability to inhibit the pathophysiologic mechanisms involved in type 2 inflammation.
Introduction Clinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack detailed profile of what features could better identify patients undergoing clinical remission. In this study, aim to address issue, tracing possible identikit fulfilling criteria. Methods We enrolled 266 with eosinophilic asthma (SEA) treated 12-month course anti-IL5/IL5 receptor (IL5r) monoclonal antibodies. Patients no exacerbation, OCS...
Abstract Background and Objective Several randomized controlled trials (RCTs) have shown that benralizumab is characterized by a good profile of efficacy safety, thereby being potentially able to elicit clinical remission on‐treatment severe eosinophilic asthma (SEA). The main goal this multicentre observational study was verify the effectiveness in inducing sustained SEA patients with or without comorbid chronic rhinosinusitis nasal polyps (CRSwNP). Methods Throughout 2 years treatment...
Background. Nowadays, highly selective biological drugs offer the possibility of treating severe type 2 asthma. However, in real-life setting, it is crucial to confirm validity chosen treatment by evaluating achievement clinical remission. Study purpose. The main aims this study were evaluate efficacy dupilumab terms clinical, functional, and inflammatory outcomes at 6, 12, 18, 24 months estimate percentage patients achieving partial or complete remission 12 treatment. In addition, we...
Background and objectives: A new phenotype with overlapping characteristics between asthma chronic obstructive pulmonary disease (COPD) called asthma–COPD overlap syndrome (ACOS) is emerging among inflammation diseases. To date, there no agreement on specific criteria to define this syndrome, the current guidelines are insufficient classify analogy differences COPD or phenotypes. It would be necessary identify biomarkers able these diseases clearly. Thus, aim of study was a serum supernatant...
Background: Asthma and bronchiectasis are different conditions that frequently coexist. The prevalence of rises considerably in subjects with severe asthma (25%–51%). Objective: We evaluated the clinical biological efficacy mepolizumab on our pilot population uncontrolled asthmatics not related to other pathologies. Patients methods: Four patients diagnosed as were recruited started treatment mepolizumab. Standard investigations performed all four at baseline (T0), after 3 months (T1) 1 year...
Background: Benralizumab can be utilized as add-on biological treatment of severe eosinophilic asthma. However, so far only a few real-life studies have been published with regard to the use this anti-IL-5 receptor humanized monoclonal antibody. Objective: The primary aim multicenter observational investigation has assess therapeutic effects benralizumab in patients uncontrolled, corticosteroid refractory secondary objective was evaluate efficacy positive or negative skin prick test (SPT)....
Introduction: Dupilumab is a monoclonal antibody targeting IL-4Rα recently licensed for severe asthma (SA). A Named Patients Program (NPP) was created in Italy before its commercial availability SA patients with no other available therapeutic options. We aimed to assess the real-world effectiveness of dupilumab and unmet needs. Methods: performed multicentre retrospective study, including admitted NPP treated 12 months. Data on number exacerbations, Asthma Control Test (ACT),...
Abstract The prognosis of the coronavirus disease 2019 (COVID-19) patients is variable and depends on several factors. Current data about impact chronic obstructive pulmonary (COPD) smoking clinical course COVID-19 are still controversial. This study evaluated prevalence COPD smokers in a cohort 521 admitted to four intermediate Respiratory Intensive Care Units (Puglia, Italy) with respiratory failure due pneumonia. current was 14% 13%, respectively. had higher 30-day all-cause mortality...
Introduction: The co-presence of bronchiectasis (BE) in severe eosinophilic asthma (SEA) is common. Data about the effectiveness benralizumab patients with SEA and BE (SEA + BE) are lacking. Aim: aim this study was to evaluate remission rates compared BE, also according severity. Methods: We conducted a multicentre observational study, including who underwent chest high-resolution computed tomography at baseline. Bronchiectasis Severity Index (BSI) used assess Clinical functional...
Background Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare vasculitis characterized by asthma, systemic manifestations, and blood tissue eosinophilia. Objective To assess the effectiveness safety of mepolizumab (anti-IL-5) benralizumab (anti-IL-5Rα) in EGPA for 24 months. Methods We conducted multicenter observational study, including patients treated anti-IL-5/Rα biologics 9 Italian specialized facilities. Systemic disease activity, remission relapse rate were evaluated from...
Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are two diseases that afflict many individuals worldwide with negative effects on health may overlap in Overlap Syndrome (OS). The aim of our study was to investigate the differences mortality between OSAS alone OS risk factors involved.
Metabolic syndrome (MetS) is a combination of metabolic disorders that concurrently act as factors promoting systemic pathologies such atherosclerosis or diabetes mellitus. It now believed to encompass six main interacting conditions: visceral fat, imbalance lipids (dyslipidemia), hypertension, insulin resistance (with without impairing both glucose tolerance and fasting blood sugar), inflammation. In the last 10 years, there has been progressive interest through scientific research...
We present a detailed analysis of the zenith angle distributions atmospheric neutrino events observed in Super-Kamiokande (SK) underground experiment, assuming two-flavor and three-flavor oscillations (with one dominant mass scale) among active neutrinos. In particular, we calculate five angular associated with sub-GeV multi-GeV \ensuremath{\mu}-like e-like to upward through-going muons, for total 30 accurately computed observables (zenith bins). First study how such vary oscillation...
<h3>Background</h3> Some patients with COPD report frequent acute exacerbations (AECOPD) of the disease (FE), whereas others suffer them infrequently (IE). Because current diagnosis exacerbation relies on patient9s perception increased symptoms (mostly dyspnoea), we hypothesised that dyspnoea might be different in FE (≥2 or 1 hospitalisation due to AECOPD previous year) IE (≤1 year), being defined by institution antibiotics and/or steroids treatment, hospital admission. <h3>Objective</h3> To...
Background: Current availability of several biologic treatments for severe asthma makes it possible to choose the most appropriate each patient. Sometimes a good percentage patients with may be eligible biologics that target either allergic phenotype or eosinophilic one, but not all respond selected as first choice. The aim our real-life study was assess whether, asthma, previously controlled by anti-IgE omalizumab, shift another targeting interleukin-5, such mepolizumab, represent...
Current mortality rate in patients with COVID-19 disease is about 2%, whereas 5% of require admission to the intensive care unit. It assumed that interleukin (IL)-6 may be involved pathogenesis severe infections; therefore, absence a specific antiviral therapy, some authors have suggested tocilizumab - drug used block signal transduction pathway IL-6 could beneficial effects management disease. However, mild-to-moderate elevation transaminases and drug-induced liver injury been observed...
Severe asthma (SA) is a chronic inflammatory disease of the airways. Due to extreme heterogeneity symptoms, new biomarkers are currently needed. MiRNAs non-coding RNAs that negatively regulate gene expression at post-transcriptional level. In biological fluids, miRNAs contained within exosomes, vesicles capable giving considerable stability and resistance degradation by RNAses. The main function attributed exosomes intercellular communication. goal our study was analyze intracellular...
There is still a debate for the link between obstructive sleep apnoea (OSA) and cancer. The mechanisms underlying this causality are poorly understood. Several miRNAs involved in cancer development progression with expression being influenced by hypoxia. aims of work were (i) to compare controls versus patients affected OSA without or (ONCO-OSA) (ii) colorectal cells exposed intermittent hypoxia (IH), evaluate impact on tumor vitro.We detected qRT-PCR patients' sera CaCo2 2-32h IH...
The atmospheric neutrino data collected by the Super-Kamiokande experiment span about four decades in energy E, and are thus appropriate to probe dependence of oscillation wavelength $\ensuremath{\lambda}$ associated with ${\ensuremath{\nu}}_{\ensuremath{\mu}}\ensuremath{\leftrightarrow}{\ensuremath{\nu}}_{\ensuremath{\tau}}$ flavor transitions, when these assumed explain data. Such a takes form ${\ensuremath{\lambda}}^{\ensuremath{-}1}\ensuremath{\propto}{E}^{n}$ wide class theoretical...