A5014730176- Obstructive Sleep Apnea Research
- Cancer, Hypoxia, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- High Altitude and Hypoxia
- Pharmaceutical Practices and Patient Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Medication Adherence and Compliance
- Economic and Financial Impacts of Cancer
- RNA modifications and cancer
- Statistical Methods in Clinical Trials
- Ethics in Clinical Research
- Hepatitis C virus research
- Lipid metabolism and disorders
- Cardiovascular Syncope and Autonomic Disorders
- Respiratory Support and Mechanisms
- Fibroblast Growth Factor Research
- Chemokine receptors and signaling
- Pharmaceutical Economics and Policy
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Extracellular vesicles in disease
Inserm
2017-2023
Université Grenoble Alpes
2013-2023
Centre Hospitalier Universitaire de Grenoble
2013-2023
Grenoble Institute of Neurosciences
2017
Nonalcoholic fatty liver disease (NAFLD) is independently linked to cardiometabolic morbidity and mortality. Low-grade inflammation, oxidative stress ectopic fat, common features of chronic obstructive pulmonary (COPD), might contribute the development NAFLD. We aimed investigate prevalence NAFLD evaluate relationship between various types damage COPD severity, comorbidities circulating inflammatory cytokines. Validated noninvasive tests (FibroMax: SteatoTest, NashTest FibroTest) were used...
There is still a debate for the link between obstructive sleep apnoea (OSA) and cancer. The mechanisms underlying this causality are poorly understood. Several miRNAs involved in cancer development progression with expression being influenced by hypoxia. aims of work were (i) to compare controls versus patients affected OSA without or (ONCO-OSA) (ii) colorectal cells exposed intermittent hypoxia (IH), evaluate impact on tumor vitro.We detected qRT-PCR patients' sera CaCo2 2-32h IH...
The objective of this work was to compare two generic questionnaires assessing patients' satisfaction with medication. In addition we tested whether can predict adherence medication regimens in patients chronic diseases, and which dimensions are most involved.This prospective, observational study conducted over one year a heterogeneous population various diseases. Satisfaction assessed by using the TSQM® vII SatMed-Q® questionnaires, treatment Morisky-Green questionnaire. Clinical...
Obstructive sleep apnea (OSA) is an emerging risk factor for cancer occurrence and progression, mainly mediated by intermittent hypoxia (IH). Systemic IH, a main landmark of OSA, local sustained (SH), classical feature at the core tumors, may act separately or synergistically on tumor cells. Our aim was to compare respective consequences HIF-1, endothelin-1 VEGF expression cell proliferation migration in HepG2 liver Wound healing, spheroid expansion, were evaluated cells following IH SH...
Performing hypoxia-reoxygenation cycles in cell culture with a cycle duration accurately reflecting what occurs obstructive sleep apnea (OSA) patients is difficult but crucial technical challenge. Our goal was to develop novel device expose multiple dishes intermittent hypoxia (IH) relevant OSA limited gas consumption. With flows as low 200 ml/min, our combination of plate holders gas-permeable cultureware generates rapid normoxia-hypoxia cycles. Cycles alternating 1 min at 20% O2 followed...
Obstructive sleep apnea (OSA) syndrome is characterized by chronic intermittent hypoxia and associated with an increased risk of all-cause mortality, including cancer mortality. Hepatocellular carcinoma (HCC) the most common type liver cancer, increasing incidence high However, link between HCC OSA-related remains unclear. Herein, we used a diethylnitrosamine (DEN)-induced model to investigate whether has impact on progression. To elucidate mechanisms, first evaluated status in DEN-induced...
Alcohol-associated hepatocellular carcinoma (AL-HCC) poor prognosis has been attributed to diagnosis at a later stage. However, host factors and specific health trajectories have associated with severe outcomes in alcohol-related liver disease. We hypothesize AL-HCC is not homogeneous condition but encompasses subgroups yielding different outcomes.Our aim was provide first attempt clinical phenotyping of AL-HCC.We analysed data for the calendar years 2007-2013 from French nationwide...
<b>Background:</b> Obstructive sleep apnea (OSA) is a breathing disorder associated with an increased cancer risk, but the mechanisms underlying this link remain poorly understood. Several miRNAs are involved in development and progression. Their expression can be influenced by hypoxia. The main aim of experimental study was to evaluate changes controls or patients affected OSA and/or colorectal cells exposed intermittent hypoxia (IH), their impact on tumor progression vitro. <b>Methods:</b>...
Clinical trials are an opportunity for patients to access innovative therapy, but patient inclusion in clinical can also result cost savings hospitals. Our objective was evaluate the economic impact of drug a French academic institution from perspectives both Health Insurance (FHI) and