A5081308892- Silicon Nanostructures and Photoluminescence
- Advanced biosensing and bioanalysis techniques
- Nanowire Synthesis and Applications
- Analytical Chemistry and Sensors
- Diatoms and Algae Research
- Photonic and Optical Devices
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Photonic Crystals and Applications
- Advanced Biosensing Techniques and Applications
- Biosensors and Analytical Detection
- Electrochemical sensors and biosensors
- Advancements in Transdermal Drug Delivery
- Nanoplatforms for cancer theranostics
- Protist diversity and phylogeny
- Gas Sensing Nanomaterials and Sensors
- Semiconductor materials and devices
- Bone Tissue Engineering Materials
- Molecular Junctions and Nanostructures
- Nanofabrication and Lithography Techniques
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Lipid Membrane Structure and Behavior
- Advanced Nanomaterials in Catalysis
- Graphene research and applications
National Research Council
2015-2024
Institute of Applied Science and Intelligent Systems
2020-2024
Total (Italy)
2024
University of Groningen
2023
Institute for Microelectronics and Microsystems
2011-2020
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2008-2020
Naples Anesthesia & Physician Associates
2016-2020
Consorzio Roma Ricerche
2017
National Academies of Sciences, Engineering, and Medicine
2011-2015
Institute of Polymers, Composites and Biomaterials
2014
Diatomite is a natural fossil material of sedimentary origin, constituted by fragments diatom siliceous skeletons. In this preliminary work, the properties diatomite nanoparticles as potential system for delivery drugs in cancer cells were exploited. A purification procedure, based on thermal treatments strong acid solutions, was used to remove inorganic and organic impurities from make them safe medical applications. The micrometric powder reduced mechanical crushing, sonication, filtering....
Diatomite is a natural porous silica material of sedimentary origin.
Some natural structures show three-dimensional morphologies on the micro- and nano-scale, characterized by levels of symmetry complexity well far beyond those fabricated best technologies available. This is case diatoms, unicellular microalgae, whose protoplasm enclosed in a nanoporous microshell, made hydrogenated amorphous silica, called frustule. We have studied optical properties Arachnoidiscus sp. single valves both visible ultraviolet range. found photonic effects due to diffraction...
Current advances in the fabrication of smart nanomaterials and nanostructured surfaces find wide usage biomedical field. In this context, nanosensors based on localized surface plasmon resonance exhibit unprecedented optical features that can be exploited to reduce costs, analytic times, need for expensive lab equipment. Moreover, they are promising design nanoplatforms with multiple functionalities (e.g., multiplexed detection) large integration within microelectronics microfluidics....
In this work, we report on the light focusing ability exploited by microshell of a marine organism: Coscinodiscus wailesii diatom. A 100 microm spot size red laser beam is narrowed up to less than 10 at distance 104 after transmission through regular geometry diatom structure, which thus acts as microlens. Numerical simulations electromagnetic field propagation show good qualitative agreement with experimental results. The effect due superposition waves scattered holes present surface valve....
A photochemical functionalization process which passivates the porous silicon surface of optical biosensors has been optimized as a function thickness and porosity devices. The modification characterized by contact angle measurements. Fluorescence measurements have used to investigate stability DNA single strands bound nanostructured material. dose-response curve for an label-free biosensor in 6-80 μM range realized.
Porous silicon samples have been reduced in nanometric particles by a well known industrial mechanical process, the ball grinding planetary mill; process has extended to crystalline for comparison purposes. The nanoparticles studied X-ray diffraction, infrared spectroscopy, gas porosimetry and transmission electron microscopy. We estimated crystallites size from about 50 nm 12 porous silicon. specific surface area of powders analyzed ranges between 100 m²/g 29 depending on milling time,...
A colorimetric immunosensor based on local surface plasmon resonance by gold nanoparticles is presented, and its application for the detection of human immunoglobulin G (IgG) demonstrated. The color change colloidal solution produced nanoparticle aggregation, a process that can be tuned presence analyte once are functionalized. In comparison to common functionalization techniques, procedure described here simpler, low-cost, effective in binding antibodies upright surface. dose-response curve...
Ti<sup>3+</sup> self-doped black titania is obtained by a simple annealing in air without harsh conditions nor external reducing agents.
Different spectroscopic techniques have been applied to fluorine doped ZnO powders prepared through hydrothermal synthesis, discern the effective capability of F atoms improve conductivity. From XRD analysis, no lattice distortion was observed up doping at 5 at. % concentration. Photoluminescence measurements and electron paramagnetic resonance data show that tend occupy oxygen vacancies, inducing onset luminescence centers. The resulting effect consists into increment localized charge, as...
Diatoms—unicellular photosynthetic algae—are promising natural sources of nanostructured silica. These microorganisms produce in their membrane approximately a highly ordered porous cell wall called frustule as protection from environmental stress. Diatom frustules consist hydrated silica that show peculiar properties including biocompatibility, tailorable surface chemistry, chemical inertness, and thermal stability. Frustules harvested aquatic ecosystems or diatomaceous fossil sediments...
Microneedles (MNs) are an emerging technology in pharmaceutics and biomedicine, ready to be commercialized the world market. However, solid microneedles only allow small doses time-limited administration rates. Moreover, some well-known already approved drugs need re-formulated when supplied by MNs. Instead, hollow (HMNs) for rapid, painless self-administrable microinjection of their standard formulation. Furthermore, body fluids can easily extracted analysis a reverse use HMNs, thus making...
Abstract The small molecule Galunisertib (LY2157299, LY) shows multiple anticancer activities blocking the transforming growth factor‐β1 receptor, responsible for epithelial‐to‐mesenchymal transition (EMT) by which colorectal cancer (CRC) cells acquire migratory and metastatic capacities. However, frequent dosing of LY can produce highly toxic metabolites. Alternative strategies to reduce drug side effects rely on nanoscale delivery systems that have led a medical revolution in treatment...
The characterization of partially coherent light transmission by micrometer sized valves marine diatoms is an interesting optical challenge and, from the biological point view, outmost relevance in order to understand evolution mechanisms such organisms. In present work, we have studied coming a monochromator through single Coscinodiscus wailesii diatoms. Incoming confined regular pore pattern diatom surface into spot few microns, its dimensions depending on wavelength. effect ascribed...
Direct solid phase synthesis of peptides and oligonucleotides (ONs) requires high chemical stability the support material. In this work, we have investigated passivation ability porous oxidized silicon multilayered structures by two aminosilane compounds, 3-aminopropyltriethoxysilane 3-aminopropyldimethylethoxysilane (APDMES), for optical label-free ON biosensor fabrication. We also studied spectroscopic reflectometry hybridization between a 13 bases ON, directly grown on modified in situ...
Silicon dioxide surfaces, functionalized by two aminosilane compounds (3-amino-propyl-triethoxysilane, APTES; 3-amino-propyl-dimethyl-ethoxysilane, APDMES) both dissolved in different solvents (dry ethanol and toluene), have been investigated standard techniques such as spectroscopic ellipsometry (SE), water contact angle (WCA), atomic force microscopy (AFM). Silane thicknesses between 5 80 Å found, depending on deposition conditions; surface wettabilities change, accordingly. These...