A5003013528- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Cytomegalovirus and herpesvirus research
- Hearing, Cochlea, Tinnitus, Genetics
- Proteoglycans and glycosaminoglycans research
- Angiogenesis and VEGF in Cancer
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Colorectal Cancer Screening and Detection
- Adipose Tissue and Metabolism
- Vestibular and auditory disorders
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Electrospun Nanofibers in Biomedical Applications
- Neuroendocrine Tumor Research Advances
- Herpesvirus Infections and Treatments
- Exercise and Physiological Responses
- Cancer Research and Treatments
- Wound Healing and Treatments
- Genomics, phytochemicals, and oxidative stress
University of Utah
2016-2025
University of Nevada, Reno
2024
Thomas Jefferson University Hospital
2024
Primary Children's Hospital
2023
University of Utah Hospital
2020
Huntsman Cancer Institute
2010-2018
ARUP Laboratories (United States)
2018
The University of Texas MD Anderson Cancer Center
2015-2016
Centre International de Recherche sur le Cancer
2016
Duke Medical Center
2016
Although B cell response is frequently found in cancer, there little evidence that it alters tumor development or progression. The process through which tumor-associated antigens trigger humoral not well delineated. We investigate the repertoire of associated with immune pancreatic ductal adenocarcinoma (PDAC) using in-depth proteomic profiling immunoglobulin-bound proteins from PDAC patient plasmas and identify induce antibody together exosome hallmark proteins. Additional cell-derived...
Abstract Objectives To assess the relationship between telomere length and adiposity, using dual‐energy X‐ray absorptiometry (DXA) magnetic resonance imaging (MRI), in addition to conventional anthropometric proxies including body mass index (BMI) cardiovascular disease risk factors. Methods A cross‐sectional sample of 309 non‐Hispanic white participants Fels Longitudinal Study aged 8 80 yr (52% female) was included. Average measured by quantitative PCR. Results Telomere negatively...
Aging promotes accumulation of reactive oxygen/nitrogen species (ROS/RNS) in cardiomyocytes, which leads to contractile dysfunction and cardiac abnormalities. These changes may contribute increased cardiovascular disease the elderly. Inducible antioxidant pathways are regulated by nuclear erythroid 2 p45-related factor (Nrf2) through response cis-elements (AREs) impaired aging heart. Whereas acute exercise stress (AES) activates Nrf2 signaling myocardial function young mice (∼2 months),...
Inheritable missense mutations in small molecular weight heat-shock proteins (HSP) with chaperone-like properties promote self-oligomerization, protein aggregation, and pathologic states such as hypertrophic cardiomyopathy humans. We recently described that human mutant αB-crystallin (hR120GCryAB) overexpression caused aggregation (PAC) was genetically linked to dysregulation of the antioxidant system reductive stress (RS) mice. However, mechanism induces RS remains only partially...
Background: CA19-9, which is currently in clinical use as a pancreatic ductal adenocarcinoma (PDAC) biomarker, has limited performance detecting early-stage disease. We and others have identified protein biomarker candidates that the potential to complement CA19-9. carried out sequential validations starting with 17 determine markers marker combination would improve detection of disease compared CA19-9 alone. Methods: Candidate biomarkers were subjected enzyme-linked immunosorbent assay...
RF3 was initially characterized as a factor that stimulates translational termination in an vitro assay. The has GTP binding site and shows sequence similarity to elongation factors EF-Tu EF-G. Paradoxically, addition of abolishes stimulation the classical assay, using stop triplets.We here show hydrolysis, which is only dependent on simultaneous presence ribosomes. Applying new uses minimessenger RNA instead separate triplets, we at rate-limiting concentrations RF1. We can substitute for...
Pancreatic ductal adenocarcinoma (PDAC) has a dismal 5-year survival rate of 5%. There is an urgent need for early detection while the tumors are small and surgically resectable. We assessed serum osteopontin (OPN) tissue inhibitor metalloproteinase 1 (TIMP-1) as possible diagnostic prognostic biomarkers in novel cohort patients with pancreatic cancer.Osteopontin TIMP-1 levels were determined sera from 86 PDAC, healthy control subjects, 48 chronic pancreatitis. Regression models used to...
Proteomic analyses of readily obtained human fluids (e.g., serum, urine, and saliva) indicate that the diagnosis complex diseases will be enhanced by simultaneous measurement multiple biomarkers from such samples. This paper describes development a nanoparticle-based multiplexed platform has potential for read-out large numbers biomolecules. For this purpose, we have chosen pancreatic adenocarcinoma (PA) as test bed prognosis. PA is devastating form cancer in which an estimated 86% diagnoses...
The incidence and death rate of pancreatic ductal adenocarcinoma (PDAC) have increased in recent years, therefore the identification novel targets for treatment is extremely important. Interactions between cancer stromal cells are critically involved tumour formation development metastasis. Here we report that PDAC secrete BAG3, which binds activates macrophages, inducing their activation secretion supporting factors. We also identify IFITM-2 as a BAG3 receptor show it signals through PI3K...
When epithelia become too crowded, some cells are extruded that later die. To extrude, a cell produces the lipid, Sphingosine 1-Phosphate (S1P), which activates S1P 2 receptors in neighboring seamlessly squeeze out of epithelium. Here, we find extrusion defects can contribute to carcinogenesis and tumor progression. Tumors or lacking cannot extrude apically instead form apoptotic-resistant masses, possess poor barrier function, shift basally beneath epithelium, providing potential mechanism...