A5001338039- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Neuropeptides and Animal Physiology
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Glycosylation and Glycoproteins Research
- Click Chemistry and Applications
- Radiopharmaceutical Chemistry and Applications
- Porphyrin and Phthalocyanine Chemistry
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Carbohydrate Chemistry and Synthesis
- Receptor Mechanisms and Signaling
- Polysaccharides and Plant Cell Walls
- Microwave-Assisted Synthesis and Applications
- Antimicrobial Peptides and Activities
- Neuroendocrine Tumor Research Advances
- Cardiovascular Function and Risk Factors
- Chemokine receptors and signaling
- Multiple Myeloma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Advanced Biosensing Techniques and Applications
- Nanocomposite Films for Food Packaging
- Synthesis of Organic Compounds
- Renal cell carcinoma treatment
University of Salerno
2025
Institute of Biostructure and Bioimaging
2015-2024
National Research Council
2015-2024
Magna Graecia University
2021-2024
Naples Anesthesia & Physician Associates
2015-2020
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi
2000-2018
University of Naples Federico II
2004-2018
University of the Sciences
2017
Gonzaga University
2016-2017
National Academies of Sciences, Engineering, and Medicine
2010-2015
Background: Obesity impairs renal function through direct mechanisms, such as proinflammatory adipocytokine production, and indirect including obesity-related comorbidities. Despite the increasing prevalence of obesity chronic kidney disease (CKD), clinical guidelines for their combined management remain lacking. Very Low Energy Ketogenic Therapy (VLEKT) has demonstrated efficacy in weight loss, but evidence on its safety individuals with mild impairment is limited. This study aimed to...
The zeolites are porous solid structures characterized by a particular framework of aluminosilicates, in which the incorporation Al+3 ions generates an excess negative charge compensated cations (usually alkali or earth) protons. In latter case, they employed as catalysts for wide variety reactions, such dehydration, skeletal isomerization and cracking, while catalytic activity basic has not found, up to now, any industrial whatever relevant application chemical processes. present review, we...
OBJECTIVE To determine the number of lymph nodes that need to be examined accurately stage pN variable in patients undergoing radical nephrectomy (RN) for renal cell carcinoma (RCC). PATIENTS AND METHODS We reviewed operative and pathology reports 725 with RCC submitted RN. All tumours were classified using fifth edition Tumour‐Nodes‐Metastasis classification. For each patient removed was recorded. The divided into five different groups according removed, i.e. group 1, 1–4; 2, 5–8; 3, 9–12;...
The CXCR4/CXCL12 axis plays a role in cancer metastases, stem cell mobilization and chemosensitization. Proof of concept for efficient CXCR4 inhibition has been demonstrated prior to autologous transplantation hematological malignancies. Nevertheless inhibitors suitable prolonged use as required anticancer therapy are not available. To develop new antagonists rational, ligand-based approach was taken, distinct from the more commonly used development strategy. A three amino acid motif...
Abstract Background Obesity is accompanied by hormonal, inflammatory and endothelial alterations. These alterations induce a stimulation of several other mechanisms that contribute to the hypertensive state increase cardiovascular morbidity. This pilot, open - label, single- center, prospective clinical trial aimed evaluate effect very low- calorie ketogenic diet (VLCKD) on blood pressure (BP) in women with obesity hypertension. Methods A total 137 women, who met inclusion criteria accepted...
Preclinical studies have highlighted the activity of lenalidomide in mantle cell lymphoma and its anti-proliferative synergy with dexamethasone.In this prospective, multicenter, phase II study, patients relapsed/refractory who were not eligible for, or had relapsed after, intensive treatments received 25 mg/day (days 1-21 each 28-day cycle) dexamethasone (40 on days 1, 8, 15, 22) for up to 12 months.The primary end-points, overall complete response rates, achieved by 17 33 (52%; 95%...
The term “overkilling” in forensic medicine is not clearly defined and used to refer homicides involving unusually massive injuries, far exceeding those necessary kill the victim. This clinical case of a dog found February 2023 town near Naples, with rope around its neck metacarpal region forelimbs. was taken Istituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM, Portici, Southern Italy), where it underwent total body radiographic study performed using “Philosophy HF400” X-ray device...
Chemical modification of pectin was successfully accomplished as a solvent free process. It involved acylation alcoholic functions the polysaccharide by using several fatty acid anhydrides. The reaction performed simply mixing reagents with catalytic amount inorganic base potassium carbonate and heating obtained mixture at temperature 160 °C. desired esters were fully characterized NMR FT-IR spectroscopy.
Microwave-assisted solvent-free modification of pectin was successfully accomplished, consisting in the esterification several fatty acids by alcoholic functions. The reaction performed simply mixing reagents with a catalytic amount inorganic base (potassium carbonate) and irradiating obtained mixture microwaves for short time (3–6 min). replacement traditional heating microwave source allowed development new synthetic protocol which provided increased yield final products, since it...
A synthetic process was developed to modify pectin samples under solvent free conditions, obtaining at increasing concentration of palmitic, oleic, and linoleic acids. The weight loss the modified powders showed a degradation path very similar pure pectin, indicating that pristine structure preserved after chemical modification. decreasing mass evaporating water on fatty acid concentration, in particular for palmitic modification, indicated reduced sorption by powders. Differential scanning...
Abstract Purpose: To test whether a novel bifunctional chimeric peptide comprising cyclic Arg-Gly-Asp pentapeptide covalently bound to an echistatin domain can discriminate αvβ3 from αvβ5 integrin, thus allowing the in vivo selective visualization of expression by single-photon and positron emission tomography (PET) imaging. Experimental Design: The was preliminarily tested for inhibition αvβ3-dependent cell adhesion competition 125I-echistatin binding membrane stably transfected K562 cells...
HER2 transmembrane receptor is an important target in immunotherapy treatment of breast and gastroesophageal cancer. Molecular imaging expression may provide essential prognostic predictive information concerning disseminated cancer aid selection optimal therapy. Radiolabeled low molecular weight peptide ligands are particularly attractive as probes for imaging, since they reach bind to the clear from non-target organs blood stream faster than bulky antibodies. In this study, we evaluated a...
Identification of molecules able to promote neuroprotective mechanisms can represent a promising therapeutic approach neurodegenerative disorders including Huntington’s disease. Curcumin is an antioxidant and agent, even though its efficacy limited by poor absorption, rapid metabolism, systemic elimination, blood–brain barrier (BBB) permeability. Herein, we report on novel biodegradable curcumin-containing nanoparticles favor the compound delivery potentially enhance brain bioavailability....
A microwave-assisted esterification reaction to prepare hyaluronan-curcumin derivatives by employing a solvent-free process was developed. In particular, solid-state strategy react two molecules characterized totally different solubility profiles Hyaluronic acid, highly hydrosoluble polysaccharide, reacted with hydrophobic and even water-unstable curcumin. Microwave (MW) irradiation employed activate the between solid compounds through direct interaction them preserve integrity of sensitive...
The antimicrobial peptide distinctin consists of two chains linked by a disulfide bridge; it presents peculiar fold in water resulting from noncovalent dimerization heterodimeric molecules. To investigate the contribution each chain and S-S bond to biochemical properties, different monomeric homodimeric analogues were synthesized comparatively evaluated with respect native molecule. Our experiments demonstrate that simultaneous occurrence both is essential for formation quaternary structure...