A5076525720- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Tracheal and airway disorders
- Cardiovascular and Diving-Related Complications
- Sleep and Wakefulness Research
- Amyotrophic Lateral Sclerosis Research
- Sleep and related disorders
- Heart Rate Variability and Autonomic Control
- Neurogenetic and Muscular Disorders Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sleep and Work-Related Fatigue
- Restless Legs Syndrome Research
- Liver Disease Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Asthma and respiratory diseases
- Spinal Cord Injury Research
- Neonatal Respiratory Health Research
- Child Nutrition and Feeding Issues
- Cardiovascular Health and Disease Prevention
- Airway Management and Intubation Techniques
- Long-Term Effects of COVID-19
- Dysphagia Assessment and Management
- Cardiovascular Syncope and Autonomic Disorders
- Alcohol Consumption and Health Effects
National Research Council
2015-2025
Institute for Biomedical Research and Innovation
2019-2025
National Academies of Sciences, Engineering, and Medicine
2011-2022
Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy
2009-2021
University of Cologne
2020
University of Pavol Jozef Šafárik
2020
Krankenhaus Bethanien
2020
University of Palermo
1988-2019
National Research Council
2016
Institut de Myologie
2011
Objective To assess spontaneous baroreceptor-heart rate reflex sensitivity during sleep in patients with obstructive apnea syndrome, a condition associated increased cardiovascular morbidity and mortality characterized by marked sympathetic activation, which is believed to originate from hypoxic chemoreceptor stimulation, although little known of other possible mechanisms such as baroreflex impairment. Design methods In 11 severe syndrome (mean ± SD age 46.8 8.1 years, apnea/hypopnea index...
The European Sleep Apnoea Database (ESADA) reflects a network of 22 sleep disorder centres in Europe enabled by COST action B26 programme. This ongoing project aims to describe differences standard clinical care patients with obstructive apnoea (OSA) and establish resource for genetic research this disorder. Patients suspected OSA are consecutively included followed up according local standards. Anthropometrics, medical history, medication, daytime symptoms data (polysomnography or...
The role of the arterial baroreflex in cardiovascular changes associated with obstructive sleep apnea syndrome (OSAS), and effect nasal continuous positive airway pressure (CPAP) treatment on function during are unknown. Baroreflex control heart rate was studied 29 normotensive patients OSAS under no treatment, 11 age-matched subjects, 10 at CPAP withdrawal after 5.5 +/- 3.7 (range 3-14) months treatment. assessed by "sequence method" analysis blood recordings (Finapres) obtained nocturnal...
Background/Aims We assessed whether obstructive sleep apnea (OSA) and nocturnal hypoxemia are associated with severity of liver fibrosis carotid atherosclerosis in patients biopsy-proven NAFLD low prevalence morbid obesity. Secondary aim was to explore the association OSA NASH pathological changes. Methods Consecutive (n = 126) chronically elevated ALT underwent STOP-BANG questionnaire estimate risk ultrasonographic assessment. In accepting perform cardiorespiratory polygraphy (PG, n 50),...
Summary The cross‐sectional relationship of obstructive sleep apnea with moderate to severe chronic kidney disease, defined as an estimated glomerular filtration rate <60 mL min −1 ∙1.73 m −2 , was investigated in a large cohort patients suspected studied by nocturnal polysomnography or cardiorespiratory polygraphy. Data were obtained from the European Sleep Apnea Database, where information unselected adult afferent 26 centres had been prospectively collected. Both Modification Diet...
Obstructive sleep apnoea (OSA) is highly prevalent and a recognised risk factor for motor vehicle accidents (MVA). Effective treatment with continuous positive airway pressure has been associated normalisation of this increased accident risk. Thus, many jurisdictions have introduced regulations restricting the ability OSA patients from driving until effectively treated. However, uncertainty prevails regarding relative importance severity determined by apnoea–hypopnoea frequency per hour...
The association of mild obstructive sleep apnea (OSA) with important clinical outcomes remains unclear. We aimed to investigate the between OSA and systemic arterial hypertension (SAH) in European Sleep Apnea Database cohort.In a multicenter sample 4,732 participants, we analyzed risk (subclassified into 2 groups: mildAHI 5-<11/h (apnea-hypopnea index [AHI], 5 <11 events/h) 11-<15/h (AHI, ≥11 <15 compared nonapneic snorers for prevalent SAH after adjustment relevant confounding factors...
Excessive daytime sleepiness (EDS) is a symptom of obstructive sleep apnea (OSA) that resolves under treatment with continuous positive airway pressure (CPAP). In some patients, persists despite CPAP treatment. We retrospectively analyzed data on subjective residual EDS, assessed as an Epworth Sleepiness Scale score (ESS) &gt;10, in patients from the European Sleep Apnea Database ( n = 4,853, mean age ± SD 54.8 11.8 years, 26.1% females), at baseline and first visit (median follow-up: 5...
Baroreflex control of heart rate during sleep (baroreflex sensitivity; BRS) has been shown to be depressed in obstructive apnoea (OSA), and improved after treatment with continuous positive airway pressure (CPAP). Whether CPAP also acutely affects BRS uncomplicated severe OSA is still debatable. Blood was monitored nocturnal polysomnography 18 patients at baseline first-time application. Spontaneous analysed by the sequence method, estimated as mean slope. did not affect blood or but...
Summary Obstructive sleep apnea often coexists with visceral adiposity and metabolic syndrome. In this study, we analysed gender‐related differences in anthropometrics according to severity abnormalities. addition, the index, a recently introduced marker of cardiometabolic risk, was analysed. Consecutive subjects suspected obstructive ( n = 528, 423 males, mean age ± standard deviation: 51.3 12.8 years, body mass index: 31.0 6.2 kg m −2 ) were studied by full polysomnography (apnea–hypopnea...
This study aimed to examine feasibility of inspiratory muscle strength tests, such as maximal pressure (MIP) and sniff nasal (SNIP) in adult patients affected by spinal muscular atrophy (SMA), well their ability, along with forced vital capacity (FVC), predict noninvasive ventilation (NIV) needs. Additionally, we evaluated effectiveness respiratory oscillometric measurements the same patients. Twenty were retrospectively evaluated. NIV requirement was considered peak nocturnal transcutaneous...
This study aimed to investigate the effect of periodic breathing (PB) at high altitude on sleep structure and arterial oxygen saturation (Sa,O2). Five healthy subjects underwent polysomnographic studies sea level, during first fourth week sojourn 5,050 m. Their pattern, architecture Sa,O2 were analysed. PB was detected in high-altitude nonrapid eye movement (NREM) tended increase from week. Stages 3-4 absent four week, but only one irrespective amount PB. The arousal index 11.6+/-3.8...