A5056169745- Obstructive Sleep Apnea Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Sleep and related disorders
- Respiratory Support and Mechanisms
- Sleep and Wakefulness Research
- Cardiovascular and Diving-Related Complications
- Respiratory and Cough-Related Research
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Sleep and Work-Related Fatigue
- Sarcoidosis and Beryllium Toxicity Research
- Cardiovascular Disease and Adiposity
- Health disparities and outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Restless Legs Syndrome Research
- Global Health Care Issues
- Pediatric health and respiratory diseases
- Climate Change and Health Impacts
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
Democritus University of Thrace
2016-2025
University Hospital of Alexandroupolis
2014-2024
University of Washington
2021-2024
Institute for Health Metrics and Evaluation
2021-2024
National and Kapodistrian University of Athens
2023
Tehran University of Medical Sciences
2023
Polyclinic General Hospital
2022
Spitalul Clinic Dr. Victor Babes
2022
Turku University Hospital
2022
University of Turku
2022
The implication of T cells in the pathogenesis idiopathic pulmonary fibrosis (IPF) is controversial. CD4(+)CD25(+)FOXP3(+) regulatory (Tregs) are pivotal maintaining immune homeostasis, but their role IPF pathophysiology has not yet been studied.To explore Treg dynamics and function IPF.Treg levels were analyzed by flow cytometry peripheral blood (PB) bronchoalveolar lavage (BAL) 21 patients with IPF, 35 lung diseases other than (patients without IPF), 20 collagen vascular parenchymal...
study objectives: Several lines of evidence suggest immune system derangement in obstructive sleep apnea syndrome (OSAS) patients.However, no data exist on the long-term effect continuous positive airway pressure (CPAP) treatment systemic immunity.Hence, we sought to evaluate this various immunological parameters OSAS patients.design: Prospective case series.setting: Sleep unit a general hospital.Patients: Newly-diagnosed, nonsmoking, otherwise healthy male patients (n = 52) were evaluated...
<br><b>Background:</b> Shift work is associated with sleep disruption, impaired quality of life, and a risk factor for several health conditions. Aim this study was to investigate the impact shift on life health-care workers (HCW). <b>Settings:</b> Tertiary University hospital in Greece. <b>Study Design:</b> Cross-sectional study. <b>Materials Methods:</b> Included were HCW, working either an irregular system or exclusively morning shifts. All participants answered WHO-5 Well-Being Index...
Background-Aim: Medical students have been greatly affected by the COVID-19 pandemic due to their educational program, which comprises theoretical knowledge and also clinical duties, making them vulnerable viral exposures possibly affecting everyday life. The aim of this study was explore changes in sleep mental health parameters among medical Greece during second year pandemic. Methods: This cross-sectional comprised all schools ( n = 7), using an anonymous online survey. Participants...
Summary The cross‐sectional relationship of obstructive sleep apnea with moderate to severe chronic kidney disease, defined as an estimated glomerular filtration rate <60 mL min −1 ∙1.73 m −2 , was investigated in a large cohort patients suspected studied by nocturnal polysomnography or cardiorespiratory polygraphy. Data were obtained from the European Sleep Apnea Database, where information unselected adult afferent 26 centres had been prospectively collected. Both Modification Diet...
The association of mild obstructive sleep apnea (OSA) with important clinical outcomes remains unclear. We aimed to investigate the between OSA and systemic arterial hypertension (SAH) in European Sleep Apnea Database cohort.In a multicenter sample 4,732 participants, we analyzed risk (subclassified into 2 groups: mildAHI 5-<11/h (apnea-hypopnea index [AHI], 5 <11 events/h) 11-<15/h (AHI, ≥11 <15 compared nonapneic snorers for prevalent SAH after adjustment relevant confounding factors...
The aim of this study was to determine if the lockdown measures applied due pandemic Coronavirus Disease 2019 (COVID-19) affected sleep general population and health professionals in six different countries (Greece, Switzerland, Austria, Germany, France, Brazil). We used a web-based survey with short questionnaire 13 questions, translated into four languages (Greek, German, French, Portuguese). included information about demographic professional data, quantitative qualitative characteristics...
Evidence from large epidemiological studies has shown that obesity may predispose to increased Th2 inflammation and increase the odds of developing asthma. On other hand, there is growing evidence suggesting metabolic dysregulation occurs with obesity, more specifically hyperglycemia insulin resistance, modify immune cell function in some degree systemic inflammation. Insulin resistance seldom on its own, most cases constitutes a clinical component syndrome, along central dyslipidemia....
Introduction . Emerging evidence supports the role of epidermal growth factor-receptor (EGFR) in fibrogenesis. The aim our study was to investigate expression profiles EGFR three forms IIPs, including idiopathic pulmonary fibrosis (IPF), cryptogenic organizing pneumonia (COP), and nonspecific interstitial (NSIP). Patients Methods Twenty newly diagnosed patients with IPF, 15 COP, NSIP (cellular,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Patients with overlap syndrome (OS), that is obstructive sleep apnea (OSA) and chronic pulmonary disease (COPD), are at increased risk of acute exacerbations related to COPD (AECOPD). We assessed the effect CPAP compliance on AECOPD, symptoms function in OS patients.Consecutive patients underwent assessment baseline 12 months under treatment of: AECOPD hospitalizations, Assessment Test (CAT) modified British Medical Research Council (mMRC) questionnaires, testing 6-min walking test (6MWT).In...
Aim The impact of obstructive sleep apnoea (OSA)–COPD overlap syndrome (OVS) on quality and cardiovascular outcomes has not been fully explored. We aimed to compare clinical polysomnographic characteristics patients with OVS versus OSA, explore pathophysiological links between comorbidities. Study design methods This cross-sectional analysis initially included data from 5600 OSA lung function in the European Sleep Apnoea Database. Two subgroups (n=1018) or (n=509) were matched (2:1) based...
Pulmonary manifestations of vasculitis are associated with significant morbidity and mortality in affected individuals. They result from a complex interplay between immune dysregulation, which leads to vascular inflammation tissue damage. This review explored the underlying pathogenesis pulmonary involvement vasculitis, encompassing various forms such as granulomatosis polyangiitis (GPA), microscopic (MPA), eosinophilic (EGPA), anti-GBM disease. Mechanisms involving ANCA autoantibodies,...
The coexistence of chronic obstructive pulmonary disease (COPD) and sleep apnea (OSA) in the same patient is referred to as overlap syndrome (OS). Patients with OS suffer more frequently from cardiovascular (CVD) carry a higher risk COPD-related exacerbations than patients COPD alone, especially when OSA left untreated. Based on recent evidence, triple therapy, namely inhaled corticosteroid/long-acting muscarinic antagonist/long-acting beta-agonist (ICS-LABA-LAMA), treatment strategy history...
Background/Objectives: The study examined the relationships between specific Theory-of-Mind (ToM) dimensions, cognitive planning, and sleep duration in aging adults. Methods: sample included 179 participants, comprising 46 cognitively healthy individuals, 75 diagnosed with amnestic Mild Cognitive Impairment (aMCI), 58 non-amnestic (naMCI). mean age of participants was 70.23 years (SD = 4.74), a educational attainment 12.35 3.22) gender distribution 53 men 126 women. ToM assessment tasks...