Xiaoling Liao
A5055474144- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Nuclear Receptors and Signaling
- Adenosine and Purinergic Signaling
- Macrophage Migration Inhibitory Factor
- Chemokine receptors and signaling
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Caveolin-1 and cellular processes
- Erythrocyte Function and Pathophysiology
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Microtubule and mitosis dynamics
Fourth People's Hospital of Sichuan Province
2023
Chongqing University of Science and Technology
2022
Glioblastoma (GBM) constitutes the most lethal primary brain tumor for which immunotherapy has provided limited benefit. The unique immune landscape is reflected in a complex microenvironment (TIME) GBM. Here, single-cell sequencing of GBM TIME revealed that microglia were under severe oxidative stress, induced nuclear receptor subfamily 4 group A member 2 (NR4A2)-dependent transcriptional activity microglia. Heterozygous Nr4a2 (Nr4a2+/-) or CX3CR1+ myeloid cell-specific...
<p>Supplemental Figure S7 describes that oxidative stress in microglia as an independent predictor for clinical outcome glioma patients.</p>
<p>Table S1 describes glioma patients and tissue samples information for evaluating the relationship of oxidative stress in microglia prognosis</p>
<p>Table S3 describes primer information for qPCR analysis.</p>
<p>Supplemental Figure S1 describes elevated oxidative stress challenge in the microglia of glioma.</p>
<p>Supplemental Figure S2 describes that oxidative stress in microglia promotes the immunosuppressive functions of microglia.</p>
<div>Abstract<p>Glioblastoma (GBM) constitutes the most lethal primary brain tumor for which immunotherapy has provided limited benefit. The unique immune landscape is reflected in a complex microenvironment (TIME) GBM. Here, single-cell sequencing of GBM TIME revealed that microglia were under severe oxidative stress, induced nuclear receptor subfamily 4 group A member 2 (NR4A2)–dependent transcriptional activity microglia. Heterozygous <i>Nr4a2</i>...
<p>Supplemental Figure S5 describes that genetic knockout of Nr4a2 in microglia reverses immunosuppressive state.</p>
<p>Table S4 describes list of literature-based immune marker panel selected to identity cell types obtained clusters.</p>
<p>Supplemental Figure S2 describes that oxidative stress in microglia promotes the immunosuppressive functions of microglia.</p>
<p>Supplemental Figure S1 describes elevated oxidative stress challenge in the microglia of glioma.</p>
<p>Supplemental Figure S6 describes that inhibition of NR4A2 or SQLE improves the therapeutic efficacy immune checkpoint blockade.</p>
<div>Abstract<p>Glioblastoma (GBM) constitutes the most lethal primary brain tumor for which immunotherapy has provided limited benefit. The unique immune landscape is reflected in a complex microenvironment (TIME) GBM. Here, single-cell sequencing of GBM TIME revealed that microglia were under severe oxidative stress, induced nuclear receptor subfamily 4 group A member 2 (NR4A2)–dependent transcriptional activity microglia. Heterozygous <i>Nr4a2</i>...
<p>Supplemental Figure S4 describes that NR4A2-knockdown affects lipid metabolism and promotes antigen presentation of microglia.</p>
<p>Supplemental Figure S4 describes that NR4A2-knockdown affects lipid metabolism and promotes antigen presentation of microglia.</p>
<p>Supplemental Figure S3 describes that inhibiting nuclear translocation of NR4A2 hampers immunosuppressive functions and promotes antigen presentation capacities microglia.</p>
<p>Supplemental Figure S5 describes that genetic knockout of Nr4a2 in microglia reverses immunosuppressive state.</p>
<p>Table S3 describes primer information for qPCR analysis.</p>
<p>Supplemental Figure S7 describes that oxidative stress in microglia as an independent predictor for clinical outcome glioma patients.</p>
<p>Table S1 describes glioma patients and tissue samples information for evaluating the relationship of oxidative stress in microglia prognosis</p>
<p>Supplemental Figure S3 describes that inhibiting nuclear translocation of NR4A2 hampers immunosuppressive functions and promotes antigen presentation capacities microglia.</p>
<p>Table S4 describes list of literature-based immune marker panel selected to identity cell types obtained clusters.</p>