A5046150977- Natural product bioactivities and synthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phytochemistry and Biological Activities
- Plant chemical constituents analysis
- Pharmacological Effects of Natural Compounds
- Traditional and Medicinal Uses of Annonaceae
- Bioactive natural compounds
- Cancer Treatment and Pharmacology
- Antimicrobial Resistance in Staphylococcus
- Synthesis and biological activity
- Sirtuins and Resveratrol in Medicine
- Ginger and Zingiberaceae research
- Essential Oils and Antimicrobial Activity
- Antimicrobial Peptides and Activities
- Phytochemical compounds biological activities
- Phytochemical Studies and Bioactivities
- Alkaloids: synthesis and pharmacology
- Sesquiterpenes and Asteraceae Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Carbohydrate Chemistry and Synthesis
- Food Safety and Hygiene
- Synthesis and Biological Activity
- Cancer, Hypoxia, and Metabolism
- Berberine and alkaloids research
Fudan University
2015-2024
Tongren University
2024
Pudong Medical Center
2024
Nanjing Normal University
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Tianjin University of Traditional Chinese Medicine
2021
Beijing Sport University
2018
Purdue University West Lafayette
2014-2017
Huashan Hospital
2016
A Mannich–Michael combo: An efficient and highly enantioselective cascade process by H-bonding catalysis for the synthesis of functionalized tetrahydroquinolines has been developed. indane amine-thiourea small molecule discovered to catalyze this in high yields with good diastereomeric ratios excellent enantioselectivities (see scheme). Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They...
Treating staphylococcal biofilm-associated infections is challenging. Based on the findings that compound 2 targeting HK domain of Staphylococcus epidermidis YycG has bactericidal and antibiofilm activities against staphylococci, six newly synthesized derivatives were evaluated for their antibacterial activities. The inhibited autophosphorylation recombinant YycG' IC50 values ranged from 24.2 to 71.2 μM. displayed activity planktonic S. or aureus strains in MIC range 1.5-3.1 All had 6- 24-h...
The accumulation and deposition of beta-amyloid (Aβ) are key neuropathological hallmarks Alzheimer's disease (AD). PARP16, a Poly(ADP-ribose) polymerase, is known tail-anchored endoplasmic reticulum (ER) transmembrane protein that transduces ER stress during pathological processes. Here, we found PARP16 was significantly increased in the hippocampi cortices APPswe/PS1dE9 (APP/PS1) mice hippocampal neuronal HT22 cells exposed to Aβ, suggesting positive correlation between progression AD...
Five new compounds, two degraded terpene glycosides, dasycarpusides A and B (1, 2), three phenolic 2-methoxy-4-hydroxymethylphenol 1-O-alpha-rhamnopyranosyl-(1"-->6')- beta-glucopyranoside ( 3), 2-methoxy-4-acetylphenol 1-O-alpha-rhamnopyranosyl-(1"-->6')-beta-glucopyranoside (4), 2-methoxy-4-(8-hydroxyethyl)-phenol (5), were isolated from the water-soluble constituents of root bark Dictamnus dasycarpus Turcz.(Rutaceae). Their structures elucidated by spectroscopic analysis chemical...
A new lignan glycoside, (7S,8R)-guaiacylglycerol-ferulic acid ether-7-O-β-D-glucopyranoside (1), along with five known phenylpropanoids (2-6) and seven phenylpropanoid glycosides (7-13), were isolated from the stems of Zanthoxylum armatum DC. Their structures elucidated by spectroscopic analysis. Compounds 2-8 11-13 first Rutaceae others for time Z. armatum.
Twelve phenolic compounds, including four novel skeleton planchols A-D (1-4), together with pairs of isomeric flavanoids (5-12) were isolated from the root Actinidia chinensis Planch (Actinidiaceae). Their structures elucidated by spectroscopic analysis and chemical evidence. The structure 1 was further confirmed a single-crystal X-ray diffraction determination. Moreover, it found that 2 showed remarkable cytotoxic activity against P-388 A-549 cell lines.
Two new flavonoids, 6,8,3′,4′-tetrahydroxy-2′-methoxy-7-methylisoflavanone (1) and 6,8,3′,4′-tetrahydroxy-2′-methoxy-6′-(1,1-dimethylallyl)-isoflavone (2), were isolated from the 95% ethanolic extract of dried roots Lespedeza cuneata together with betulinic acid (3), β-sitosterol (4), hexacosanoic 2,3-dihydroxy-propyl ester (5), which this plant for first time. Their structures elucidated by spectral analysis.
Two new phenolic glycoside, 2-methoxy-4-hydroxylphenyl-1-O-α-L-rhamnopyranosyl- (1″ → 6')-β-D-glucopyranoside. (1) and threo-3-methoxy-5-hydroxy-phenylpropanetriol-8-O-β-D-glucopyranoside (2), were isolated from the stems of Zanthoxylum armatum. The compounds 1 2 showed weak scavenging activity in DPPH free radical assay with IC50 values 323 114 mM, respectively.
From the water-soluble constituents of root bark Dictamnus dasycarpus, six new eudesmane-type sesquiterpene glycosides, dictamnosides H-M (1-6), and a trinorguaiane-type glycoside, dictamnoside N (7), together with four known A (8), B (9), D (10), G (11), were isolated. Their structures elucidated by spectroscopic analyses chemical evidence. In vitro tests for immunological activity showed (8) to possess remarkable in stimulating proliferation T-cells.
Six novel 4,5-seco-rearranged abietane diterpenoids, including one tetracyclic diterpenoid, prionoid A (1), two tricyclic prionoids B (2) and C (3), three dicyclic D (4), E (5), F (6), were isolated from the roots of Salvia prionitis Hance (Labiatae). Their structures elucidated using spectroscopic analysis. The structure 1 was further confirmed by a single-crystal X-ray diffraction determination. Moreover, it found that 4 (IC50 = 0.41 microM) 5 0.72 showed significant cytotoxic activity...