Gwendolyn Osborne

ORCID: 0000-0003-0466-6865
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About
Contact & Profiles
Research Areas
  • Carcinogens and Genotoxicity Assessment
  • Effects and risks of endocrine disrupting chemicals
  • Nutritional Studies and Diet
  • Toxic Organic Pollutants Impact
  • Health, Environment, Cognitive Aging
  • Cancer Risks and Factors
  • Water Treatment and Disinfection
  • Metabolomics and Mass Spectrometry Studies
  • Gut microbiota and health
  • Chemistry and Chemical Engineering
  • Environmental Justice and Health Disparities
  • Air Quality and Health Impacts
  • Heavy Metal Exposure and Toxicity
  • Birth, Development, and Health
  • Pharmacogenetics and Drug Metabolism
  • Chemical Safety and Risk Management
  • Pesticide Exposure and Toxicity
  • Vitamin D Research Studies
  • Animal testing and alternatives
  • Occupational and environmental lung diseases

California Environmental Protection Agency
2017-2024

New York University
2019

University of California, Berkeley
2015

Center for Environmental Health
2015

Many nitrosamines are potent carcinogens, with more than 30 listed under California's Proposition 65. Recently, nitrosamine contamination of commonly used drugs for treatment hypertension, heartburn, and type 2 diabetes has prompted numerous Food Drug Administration (FDA) recalls in the US. These contaminants include carcinogens NDMA (N-nitrosodimethylamine) NDEA (N-nitrosodiethylamine) animal tumorigen NMBA (N-nitroso-N-methyl-4-aminobutyric acid). metabolically and/or structurally related...

10.3390/ijerph18189465 article EN International Journal of Environmental Research and Public Health 2021-09-08

The ten key characteristics (KCs) of carcinogens are based on known human and encompass many types endpoints. We propose that an objective review the large amount cancer mechanistic evidence for chemical bisphenol A (BPA) can be achieved through use these KCs. search metabolic data relevant to carcinogenicity BPA was conducted web-based software tools were used screen organize results. applied KCs systematically identify, organize, summarize information BPA, bring carcinogenic mechanisms...

10.1177/10915818231225161 article EN International Journal of Toxicology 2024-01-10

Our objective was to investigate the relationship between gut microbiota and anthropometric measurements among 248 participants from Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. cohort represents a unique population that allows for investigation lean individuals. We measured height, weight, arm, thigh, hip, waist circumferences, collected fecal samples. Microbial DNA extracted stool samples sequenced by 16S rRNA gene sequencing. examined associations relative abundance...

10.1080/19490976.2019.1614394 article EN Gut Microbes 2019-05-29

Objectives The US National Toxicology Program (NTP) recently recommended in its Report on Carcinogens Monograph for Antimony Trioxide that antimony trioxide be listed as ‘ reasonably anticipated to a human carcinogen ’ based sufficient evidence of carcinogenicity experimental animals and supporting from mechanistic studies. Our goal was estimate the possible cancer risk occupational exposure trioxide. Methods We selected data 2-year inhalation studies male female mice conducted by NTP...

10.1136/oemed-2020-106980 article EN Occupational and Environmental Medicine 2020-11-26

Abstract Dibenzanthracenes (DBAs) are identified as carcinogens and on the California Proposition 65 list. DBAs five-ring polycyclic aromatic hydrocarbons (PAHs). This chemical group consists of three isomers: DB[a,c]A, DB[a,h]A, DB[a,j]A. products incomplete combustion or pyrolysis organic matter can be formed during high temperature cooking. They air pollutants present in engine exhaust, tobacco marijuana smoke, may also contaminate soil water. DB[a,h]A is a well-studied International...

10.1158/1538-7445.am2018-4021 article EN cc-by-nc Cancer Research 2018-07-01
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