A5051948953- Phytoestrogen effects and research
- Cancer Risks and Factors
- Tea Polyphenols and Effects
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Estrogen and related hormone effects
- Nutrition, Genetics, and Disease
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
- Antioxidant Activity and Oxidative Stress
- Menopause: Health Impacts and Treatments
- Phytochemicals and Antioxidant Activities
- Growth Hormone and Insulin-like Growth Factors
- Physical Activity and Health
- Food composition and properties
- Hormonal and reproductive studies
- Protein Hydrolysis and Bioactive Peptides
- Nutrition and Health in Aging
- Genomics, phytochemicals, and oxidative stress
- Breast Cancer Treatment Studies
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
University of Minnesota
2014-2024
University of Minnesota System
2017-2024
Palo Alto University
2013
Stanford University
2013
University of Delaware
2013
Loma Linda University
2013
National Institute of Health Sciences
2013
University of Pennsylvania
2009-2013
Case Western Reserve University
2013
Brigham and Women's Hospital
2013
Abstract Thirteen isoflavonoids, flavonoids, and lignans, including some known phytoestrogens, were evaluated for their effects on DNA synthesis in estrogen‐dependent (MCF‐7) ‐independent (MDA‐MB‐231) human breast cancer cells. Treatment 24 hours with most of the compounds at 20–80 μM sharply inhibited MDA‐MB‐231 In MCF‐7 cells, other hand, biphasic seen. At 0.1–10 μM, coumestrol, genistein, biochanin A, apigenin, luteolin, kaempferol, enterolactone induced 150–235% and, 20–90 pM, by 50%....
Soy isoflavones have been hypothesized to exert hormonal effects in postmenopausal women. To test this hypothesis, we studied the of three soy powders containing different levels 18 Isoflavones were consumed relative bodyweight [control: 0.11 +/- 0.01; low isoflavone (low-iso): 1.00 high (high-iso): 2.00 0.02 mg/kg/day] for 93 days each a randomized crossover design. Blood was collected on day 1 study (baseline) and 36-38, 64-66, 92-94 diet period, analysis estrogens, androgens,...
Abstract Epidemiologic and animal studies suggest a protective role of green tea against breast cancer. However, the underlying mechanism is not understood. We conducted randomized, double-blinded, placebo-controlled phase II clinical trial to investigate whether supplementation with extract (GTE) modifies mammographic density (MD), as potential mechanism, involving 1,075 healthy postmenopausal women. Women assigned treatment arm consumed daily 4 decaffeinated GTE capsules containing 1,315...
Soy isoflavones are hypothesized to be responsible for changes in hormone action associated with reduced breast cancer risk. To test this hypothesis, we studied the effects of isoflavone consumption 14 premenopausal women. Isoflavones were consumed soy protein powders and provided relative body weight (control diet, 10 ± 1.1; low 64 9.2; high 128 16 mg/day) three menstrual cycles plus 9 days a randomized cross-over design. During last 6 weeks each diet period, plasma was collected every...
Abstract Soy isoflavones are hypothesized to exert hormonal effects in women and thus may play a role bone metabolism throughout life. In 2 randomized, cross-over studies, 14 pre- 17 postmenopausal were given 3 soy protein isolates containing different amounts of [control, 0.13; low isoflavone (low-iso), 1.00; high-iso, 2.01 mg/kg body wt·day, averaging 8, 65, 130 mg/day, respectively], for over months each. Food records, blood samples, 24-h urine collections obtained the studies. The...
Lignans are a group of phytochemicals shown to have weakly estrogenic and antiestrogenic properties. Two specific lignans, enterodiol enterolactone, absorbed after formation in the intestinal tract from plant precursors particularly abundant fiber-rich food excreted urine. We evaluated effect ingestion flax seed powder, known produce high concentrations urinary on menstrual cycle 18 normally cycling women, using balanced randomized cross-over design. Each subject consumed her usual...
Abstract Phytoestrogen effects on estrogen action and tyrosine kinase activity have been proposed to contribute cancer prevention. To study these mechanisms, a number of phytoestrogens related compounds were evaluated for their DNA synthesis (estimated by thymidine incorporation analysis) in estrogen‐dependent MCF‐7 cells the presence estradiol (E2), tamoxifen, insulin, or epidermal growth factor. We observed that 1) at 0.01–10 μ?, genistein coumestrol enhanced ?2‐induced synthesis, as did...