Nathalie Gaudreault
A5081112788- Cardiac Valve Diseases and Treatments
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Infective Endocarditis Diagnosis and Management
- Neural dynamics and brain function
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Atherosclerosis and Cardiovascular Diseases
- Lung Cancer Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lipoproteins and Cardiovascular Health
- Protease and Inhibitor Mechanisms
- Genetic Associations and Epidemiology
- Neuroscience and Neuropharmacology Research
- Peroxisome Proliferator-Activated Receptors
- Pulmonary Hypertension Research and Treatments
- Metabolism, Diabetes, and Cancer
- Visual perception and processing mechanisms
- Nitric Oxide and Endothelin Effects
- Peptidase Inhibition and Analysis
- Cardiomyopathy and Myosin Studies
- Neuroendocrine Tumor Research Advances
- IL-33, ST2, and ILC Pathways
- Nutrition, Genetics, and Disease
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2016-2025
Université Laval
2016-2025
Montreal Heart Institute
2007-2023
Centre Hospitalier Universitaire de Sherbrooke
2023
Université de Sherbrooke
2016-2023
Lung Institute
2012-2020
Allen Institute for Brain Science
2017-2019
Allen Institute
2017-2019
Cégep de Chicoutimi
2016
Centre hospitalier universitaire de Québec
2015
Calcific aortic valve disease is characterized by an abnormal mineralization of the valve. Osteogenic activity in under control NOTCH1, which regulates expression key pro-osteogenic genes such as RUNX2 and BMP2. Long noncoding RNAs (lncRNAs) may reprogram cells altering gene pattern.Multidimensional genomic profiling was performed human valves to document lncRNAs DNA methylation pattern calcific disease. In-depth functional assays were carried out impact lncRNA on valve.We documented that...
Abstract To identify candidate causal genes of asthma, we performed a genome-wide association study (GWAS) in UK Biobank on broad asthma definition (n = 56,167 cases and 352,255 controls). We then carried out functional mapping through transcriptome-wide studies (TWAS) Mendelian randomization lung 1,038) blood 31,684) tissues. The GWAS reveals 72 asthma-associated loci from 116 independent significant variants (P < 5.0E-8). most TWAS gene 17q12-q21 is GSDMB 1.42E-54). Other include TSLP...
Summary To understand how the brain processes sensory information to guide behavior, we must know stimulus representations are transformed throughout visual cortex. Here report an open, large-scale physiological survey of neural activity in awake mouse cortex: Allen Brain Observatory Visual Coding dataset. This publicly available dataset includes cortical from nearly 60,000 neurons collected 6 areas, 4 layers, and 12 transgenic lines 221 adult mice, response a systematic set stimuli. Using...
Cigarette smoking is the leading risk factor for lung cancer. To identify genes deregulated by and to distinguish gene expression changes that are reversible persistent following cessation, we carried out genome-wide profiling on nontumor tissue from 853 patients with Gene levels were compared between never current smokers, time-dependent in studied former smokers. A total of 3,223 transcripts differentially expressed groups discovery set (n = 344, P < 1.29 × 10(-6)). substantial number...
As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer's disease (AD) have not led to effective treatments, and there is increasing evidence of a disconnect between traditional pathology cognitive abilities with advancing age, indicative individual variation resilience pathology. Here, we generated comprehensive neuropathological, molecular,...
Abstract Calcific aortic valve stenosis (CAVS) is a common and life-threatening heart disease the current treatment options cannot stop or delay its progression. A GWAS on 1009 cases 1017 ethnically matched controls was combined with large-scale eQTL mapping study of human tissues ( n = 233) to identify susceptibility genes for CAVS. Replication performed in UK Biobank, including 1391 352,195 controls. transcriptome-wide association (TWAS) reveals PALMD (palmdelphin) as significantly...
Vascular endothelial growth factor (VEGF)-C plays an important role in lymphangiogenesis; however, functional responses of lymphatic vessels to VEGF-C have not been characterized. We tested the hypothesis that VEGF-C-induced activation VEGF receptor (VEGFR)-3 increases pump output. examined vivo activity rat mesenteric collecting lymphatics using intravital microscopy during basal conditions and treatment with 1 nM recombinant VEGF-C, selective VEGFR-3 agonist VEGF-Cys(156)Ser mutation...
The scientific mission of the Project MindScope is to understand neocortex, part mammalian brain that gives rise perception, memory, intelligence, and consciousness. We seek quantitatively evaluate hypothesis neocortex a relatively homogeneous tissue, with smaller functional modules perform common computational function replicated across regions. here focus on mouse as model organism genetics, physiology, behavior can be readily studied manipulated in laboratory. describe operation cortical...
Abstract The mammalian cortex is a laminar structure composed of many cell types densely interconnected in complex ways. Recent systematic efforts to map the mouse mesoscale connectome provide comprehensive projection data on interareal connections, but not at level specific classes or layers within cortical areas. We present here significant expansion Allen Mouse Brain Connectivity Atlas, with ∼1,000 new axonal mapping experiments across nearly all isocortical areas 49 Cre driver lines....
The molecular mechanisms leading to premature development of aortic valve stenosis (AS) in individuals with a bicuspid are unknown. objective this study was identify genes differentially expressed between calcified valves (BAVc) and tricuspid (TAVc) without (TAVn) AS using RNA sequencing (RNA-Seq). We collected 10 human BAVc nine TAVc from men who underwent primary replacement. Eight TAVn were obtained heart transplantation. mRNA levels measured by RNA-Seq compared groups. Two upregulated,...
Objective— We investigated atheroprotective properties of apolipoprotein (apo) E beyond its ability to lower plasma cholesterol. hypothesized that apoE reduces atherosclerosis by decreasing lipid accumulation in circulating monocytes and the inflammatory state vascular endothelium. Methods Results— developed mice with spontaneous hyperlipidemia without apoE. Hypomorphic deficient low-density lipoprotein receptor ( Apoe h/h Ldlr −/− ) were compared mice. Despite 4-fold more than WT mice,...
Calcific aortic valve stenosis (AS) is a life-threatening disease with no medical therapy. The genetic architecture of AS remains elusive. This study combines genome-wide association studies, gene expression, and expression quantitative trait loci mapping in human tissues to identify susceptibility genes AS.A meta-analysis was performed combining the results 2 studies 474 486 cases from Quebec City (Canada) Paris (France), respectively. Corresponding controls consisted 2988 1864 individuals...
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal our study has been to integrate complete results with a large‐scale expression quantitative trait loci (eQTL) mapping in human tissues ( n = 1,038) identify candidate causal genes for cancer. performed transcriptome‐wide association (TWAS) overall, by histology (adenocarcinoma, squamous cell carcinoma small cancer) smoking subgroups (never‐ ever‐smokers)....
Circulating tumor DNA (ctDNA) positivity at diagnosis, which is associated with worse outcomes in multiple solid tumors including stage I–III non-small cell lung cancer (NSCLC), may have utility to guide (neo)adjuvant therapy. In this retrospective study, 260 patients clinical I NSCLC (180 adenocarcinoma, 80 squamous carcinoma) were allocated (2:1) high- and low-risk groups based on relapse versus disease-free status ≤5 years post-surgery. We evaluated the association of preoperative ctDNA...
The most near-term clinical application of genome-wide association studies in lung cancer is a polygenic risk score (PRS).
Pressure-induced decreases in arterial diameter are accompanied by membrane depolarization and Ca 2+ entry via voltage-gated channels. Recent evidence also suggests the involvement of sensitization contractile proteins. Both PKC Rho kinase candidate second messengers for mediation process. We investigated signaling pathways pressure-induced rat cerebral artery vessels that were depolarized with a 60 mM potassium-physiological salt solution (KPSS). Arteries mounted on pressure myograph,...
Whether single-cell RNA-sequencing (scRNA-seq) captures the same biological information as single-nucleus (snRNA-seq) remains uncertain and likely to be context-dependent. Herein, a head-to-head comparison was performed in matched normal-adenocarcinoma human lung samples assess insights derived from scRNA-seq versus snRNA-seq better understand cellular transition that occurs normal tumoral tissue. Here, transcriptome of 160,621 cells/nuclei obtained. In non-tumor lung, cell type proportions...