A5006528725- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Chromatin Remodeling and Cancer
- Genetic Associations and Epidemiology
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Colorectal Cancer Screening and Detection
- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Nutrition, Genetics, and Disease
- Retinoids in leukemia and cellular processes
- Gut microbiota and health
- Folate and B Vitamins Research
- COVID-19 Clinical Research Studies
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Vitamin C and Antioxidants Research
- Data-Driven Disease Surveillance
- Toxic Organic Pollutants Impact
- Metabolomics and Mass Spectrometry Studies
Shanghai Jiao Tong University
2024-2025
Shanghai First People's Hospital
2024-2025
Nanjing Medical University
2018-2024
Jiangsu Province Hospital
2024
Suzhou Municipal Hospital
2024
National Clinical Research Center for Digestive Diseases
2024
Genomics (United Kingdom)
2019-2021
Nantong University
2016-2017
The association between vitamin E and cancer risk has been widely investigated by observational studies, but the findings remain inconclusive. Here, we aimed to evaluate causal effect of circulating on ten common cancers, including bladder, breast, colorectal, esophagus, lung, oral pharynx, ovarian, pancreatic, prostate, kidney cancer.A Mendelian randomization (MR) analytic framework was applied data from a cancer-specific genome-wide study (GWAS) comprising total 297,699 cases 304,736...
Incidence of early-onset colorectal cancer (EOCRC), defined by a diagnosed age under 50 years, is increasing, but its heterogeneous etiologies that differ from general CRC remain undetermined. We initially characterize the genome, epigenome, transcriptome, and proteome tumors 79 patients in Chinese cohort. Data for an additional 126 EOCRC subjects are obtained International Cancer Genome Consortium cohort The Atlas European observe have high tumor mutation burden; increased DNA repair...
Inflammation-mediated crosstalk between neuroglial cells and endothelial (ECs) is a fundamental feature of many vascular diseases. Nevertheless, the landscape inflammatory processes during diabetes-induced microvascular dysfunction remains elusive. Here, we applied single-cell RNA sequencing to elucidate transcriptional diabetic retinopathy (DR). The transcriptome characteristics microglia ECs revealed two microglial subpopulations three EC populations. Exploration intercellular showed that...
The association between air pollution and childhood respiratory disease is inconsistent. In the present study, we investigated a short-term effect of ambient pollutants daily lower diseases (CLRD). Daily pollutants, weather data, CLRD data were collected from January 2014 to April 2015 (452 days) in Nanjing, China. Time-series regression generalized additive models used assess effects (PM10, PM2.5, NO2, SO2, O3, CO) on CLRD. We observed that an interquartile range (IQR) increase...
Element contamination, including that from heavy metals, is associated with gastrointestinal tumorigenesis, but the effects and mechanisms of crucial element exposure colorectal cancer remain unclear. We profiled 56 elements by ICP-MS used logistic regression, LASSO, BKMR, GAM to identify cancer-relevant elements. A series biochemical experiments were performed demonstrate cytotoxicity malignant transformation after metal exposure. Using an elementomics approach, we first found thallium (Tl)...
The development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise polygenic prognostic score (PPS) stratifying overall survival. Leveraging two cohorts 3703 patients, first perform genome-wide association analysis develop eight candidate PPSs. Further using independent cohort with 470 identify the 287 variants-derived PPS (i.e., PPS287) achieving optimal performance [hazard ratio (HR) per SD = 1.99, P 1.76 ×...
Abstract Genome-wide association studies (GWASs) underlying case-control design have uncovered hundreds of genetic loci involved in tumorigenesis and provided rich resources for identifying risk factors biomarkers associated with cancer susceptibility. However, the application GWAS determining architecture survival remains unestablished. Here, we systematically evaluated effects at genome-wide level on that included overall (OS) cancer-specific (CSS), leveraging data deposited UK Biobank...
Abstract Genetic variants in regions encoding 3′ untranslated (UTR) of mRNA potentially alter miRNA binding affinity and N6-methyladenosine (m6A) levels to affect gene expression. A better understanding the association these with colorectal cancer susceptibility could facilitate development prevention treatment approaches. Here, we analyzed expression profiles integrated genetic analyses from 8,533 individuals evaluate effects altered miRNA-binding sites on risk. The single-nucleotide...
Genetic and epigenetic alterations occur in many physiological pathological processes. The existing knowledge regarding the association of PIWI-interacting RNAs (piRNAs) their genetic variants on risk progression prostate cancer (PCa) is limited. In this study, three genome-wide study datasets are combined, including 85,707 PCa cases 166,247 controls, to uncover piRNAs. Functional investigations involved manipulating piRNA expression cellular mouse models its oncogenetic role PCa. A specific...
Abstract PIWI-interacting RNAs (piRNAs) are an emerging class of non-coding involved in tumorigenesis. Expression quantitative trait locus (eQTL) analysis has been demonstrated to help reveal the genetic mechanism single nucleotide polymorphisms (SNPs) cancer etiology. However, there no databases that have constructed provide eQTL between SNPs and piRNA expression. In this study, we collected genotyping expression data for 10 997 samples across 33 types from The Cancer Genome Atlas (TCGA)....
Abstract Polycyclic aromatic hydrocarbons (PAHs) widely exist in environmental substrates and are closely related to individual circulating vitamin D levels tumorigenesis. Therefore, we proposed evaluate the relationship between PAH exposure, D, risks for 14 cancer types via a causal inference framework underlying mediation analysis. We evaluated seven urine monohydroxylated (OH‐PAH) serum concentrations of 3306 participants from National Health Nutrition Examination Survey 2013 2016 survey...
The current study aimed to investigate associations of circRNAs and related genetic variants with risk prostate cancer (PCa) as well elucidate biological mechanisms underlying the associations. By using MiOncoCirc database, we first compared expression levels between 25 paired PCa adjacent normal tissues identify risk-associated circRNAs. We then used logistic regression models evaluate in candidate among 4662 patients 3114 healthy controls, identified <italic>circHIBADH</italic> rs11973492...
Environmental pollutants known as polycyclic aromatic hydrocarbons (PAHs) are produced through the incomplete combustion of organic material. While PAHs have been investigated genotoxicants, they can also operate nongenotoxic pathways in estrogen-dependent malignancies, such breast, cervical and ovarian cancer. However, whether induce colorectal cancer (CRC) risk estrogenic effects is still illusive. Here, we systematically abnormal expression activation estrogen receptor beta (ERβ)...
Abstract Background Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an unfavorable prognosis. A refined understanding age-based polygenic risk score (PRS) for (PCa) would essential personalized stratification. Methods We included 167,517 male participants [4882 cases including 205 and 4677 late-onset PCa (LOPC)] from UK Biobank....
Abstract Background Evidence suggests that serum retinol level is associated with prostate cancer risk, but the association between genetic variants in metabolism pathway genes and risk remains unclarified. Methods Single‐nucleotide polymorphisms (SNPs) 31 were genotyped to evaluate 4,662 cases 3,114 controls from Prostate, Lung, Colorectal Ovarian (PLCO) Cancer Screening Trial. The gene expression analysis was evaluated using data Gene Expression Omnibus (GEO) datasets Genome Atlas (TCGA)...