A5039059466- Cancer, Lipids, and Metabolism
- Advanced Proteomics Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Iron-based superconductors research
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Advanced Biosensing Techniques and Applications
- Rare-earth and actinide compounds
- Ferroptosis and cancer prognosis
- Corporate Taxation and Avoidance
- Esophageal Cancer Research and Treatment
- Ginger and Zingiberaceae research
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Physics of Superconductivity and Magnetism
- Pharmacological Effects of Natural Compounds
- Plant chemical constituents analysis
- Head and Neck Cancer Studies
- Essential Oils and Antimicrobial Activity
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Magnetic and transport properties of perovskites and related materials
- Genetic factors in colorectal cancer
Fudan University
2014-2025
Pudong Medical Center
2024-2025
Zhongshan Hospital
2022-2024
State Key Laboratory of Genetic Engineering
2022-2024
Fudan University Shanghai Cancer Center
2022-2023
Huashan Hospital
2023
Lanzhou University of Technology
2017-2019
Science and Technology on Surface Physics and Chemistry Laboratory
2016-2018
State Key Laboratory of Surface Physics
2014-2016
Collaborative Innovation Center of Advanced Microstructures
2015
Abstract Clear cell renal carcinoma (ccRCC) is a common and aggressive subtype of cancer. Here we conduct comprehensive proteogenomic analysis 232 tumor adjacent non-tumor tissue pairs from Chinese ccRCC patients. By comparing with tissues, find that shows extensive metabolic dysregulation an enhanced immune response. Molecular subtyping classifies tumors into three subtypes (GP1–3), among which the most GP1 exhibits strongest phenotype, increased metastasis, imbalance, linking...
Single-layer FeSe films with extremely expanded in-plane lattice constant of 3.99A are fabricated by epitaxially growing FeSe/Nb:SrTiO3/KTaO3 heterostructures, and studied in situ angle-resolved photoemission spectroscopy. Two elliptical electron pockets at the Brillion zone corner resolved negligible hybridization between them, indicating symmetry low energy electronic structure remains intact as a free-standing single-layer FeSe, although it is on substrate. The superconducting gap closes...
Abstract Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive heterogeneity and lack high-quality tissues for biomarker discovery, causative molecular mechanisms are far from being fully defined. Therefore, more studies needed improve current clinicopathological classification system, advanced treatment strategies such as targeted therapy immunotherapy yet be explored. Here, we performed largest integrative genomics, transcriptomics,...
Abstract Esophageal squamous cell carcinoma (ESCC) is malignant while the carcinogenesis still unclear. Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, covering 9 histopathological stages and 3 phases. Proteogenomics elucidates cancer-driving waves in progression, reveals molecular characterization alcohol drinking habit associated signatures. We discover chromosome 3q gain functions transmit nontumor to intraepithelial neoplasia...
Abstract Cetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 plasma samples originated from 147 CRC patients (CRCs) undergoing cetuximab with multi-course treatment, 90 healthy controls (HCs). COL12A1, THBS2, S100A8, S100A9 are screened as potential proteins to distinguish CRCs HCs both in tissue validation cohorts. We identify biomarkers (RRAS2, MMP8, FBLN1,...
Background and Aims: Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding few effective therapeutic approaches. We aimed at providing proteogenomic CCA characterization to inform biological processes treatment vulnerabilities. Approach Results: Integrative genomic analysis functional validation uncovered perturbations downstream of driver events including DPCR1 , RBM47 mutations, SH3BGRL2 copy number alterations, FGFR2 fusions in CCA. Proteomic clustering...
Abstract Diffuse gliomas are devastating brain tumors. Here, we perform a proteogenomic profiling of 213 retrospectively collected glioma Proteogenomic analysis reveals the downstream biological events leading by EGFR- , IDH1- TP53-mutations . The comparative illustrates distinctive features GBMs and LGGs, indicating CDK2 inhibitor might serve as promising drug target for GBMs. Further integrative combined with functional experiments highlight cis -effect EGFR alterations lead to tumor cell...
Quantitative proteomics is an indispensable tool in life science research. However, there a lack of reference materials for evaluating the reproducibility label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based measurements among different instruments and laboratories.Here, we develop Quartet standard as proteome material with built-in truths, distribute same aliquots to 15 laboratories nine conventional LC-MS/MS platforms across six cities China. Relative abundance over...
Abstract Soft tissue sarcoma is a broad family of mesenchymal malignancies exhibiting remarkable histological diversity. We portray the proteomic landscape 272 soft sarcomas representing 12 major subtypes. Hierarchical classification finds similarity features between angiosarcoma and epithelial sarcoma, elevated expression SHC1 in AS ES correlated with poor prognosis. Moreover, clustering classifies patients into 3 clusters diverse driven pathways clinical outcomes. In cluster featured high...
A key issue in heavy fermion research is how subtle changes the hybridization between $4f$ ($5f$) and conduction electrons can result fundamentally different ground states. ${\mathrm{CeRhIn}}_{5}$ stands out as a particularly notable example: when replacing Rh with either Co or Ir, antiferromagnetism gives way to superconductivity. In this photoemission study of ${\mathrm{CeRhIn}}_{5}$, we demonstrate that use resonant angle-resolved spectroscopy polarized light allows us extract detailed...
The search for novel materials with Dirac cone band dispersion is one of the most challenging and important works both fundamental physics technological applications. Here, we studied electronic structure FeSe thin films grown on $\mathrm{SrTi}{\mathrm{O}}_{3}$ substrates by angle-resolved photoemission spectroscopy (ARPES). We revealed existence dispersions in thicker than 1 unit cell below nematic transition temperature, whose apexes are located \ensuremath{-}10 meV Fermi energy. evolution...
The progression of urothelial bladder cancer (UC) is a complicated multi-step process. We perform comprehensive multi-omics analysis 448 samples from 190 UC patients, covering the whole spectrum disease stages and grades. Proteogenomic integration indicates mutations HRAS regulated mTOR signaling to form papilloma rather than papillary (PUC). DNA damage key pathway in carcinoma situ (CIS) related APOBEC signature. Glucolipid metabolism increase lower immune cell infiltration are associated...
Abstract The subtypes of duodenal cancer (DC) are complicated and the carcinogenesis process is not well characterized. We present comprehensive characterization 438 samples from 156 DC patients, covering 2 major 5 rare subtypes. Proteogenomics reveals LYN amplification at chromosome 8q gain functioned in transmit intraepithelial neoplasia phase to infiltration tumor via MAPK signaling, illustrates DST mutation improves mTOR signaling adenocarcinoma stage. Proteome-based analysis elucidates...
Abstract Background Fibroblast-like synoviocytes (FLS) are crucial for maintaining synovial homeostasis. SMYD5, a member of the histone lysine methyltransferase subfamily SMYDs, is involved in many pathological processes. This study aimed to investigate role SMYD5 regulating fibroblast homeostasis and pathogenesis rheumatoid arthritis (RA). Methods Proteomic screening was conducted assess expression synovium patients with osteoarthritis (OA) RA. In vitro, interleukin-1 beta (IL-1β) used...
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs derived from different organs with similar morphologies, it is challenging to distinguish the origin metastatic SCCs. Here we report a deep proteomic analysis 333 17 69 ACs 7 organs. Proteomic comparison between identifies distinguishable pivotal pathways molecules in those play consistent adverse or opposite prognostic roles A common rare highlights lipid metabolism may...
Upper tract urothelial carcinoma (UTUC) is often diagnosed late and exhibits poor prognosis. Limited data are available on potential non-invasive biomarkers for disease monitoring. Here, we investigate the proteomic profile of plasma in 362 UTUC patients 239 healthy controls. We present an integrated tissue-plasma approach to infer signature proteins identifying with muscle-invasive UTUC. discover a protein panel that reflects lymph node metastasis, which interest high risk also identify...
Chemoradiation and targeted therapies are the major treatments for colorectal cancer (CRC); however, molecular properties associated with therapy resistance incompletely characterized. Here, we profile proteome of 254 tumor tissues from patients CRC undergoing chemotherapy, chemoradiation, or chemotherapy combined therapy. Proteome-based classification reveals four subtypes featured distinct biological therapeutic characteristics. The integrative analysis cell lines clinical samples...
Abstract Prenatal diagnosis of congenital heart disease (CHD) relies primarily on fetal echocardiography conducted at mid‐gestational age—the sensitivity which varies among centers and practitioners. An objective method for early is needed. Here, we a case–control study recruiting 103 pregnant women with healthy offspring 104 cases CHD offspring, including VSD (42/104), ASD (20/104), other phenotypes. Plasma was collected during the first trimester proteomic analysis performed. Principal...
High-quality single crystals with nominal composition M0.05Fe0.95Te0.8Se0.2 (M = Cr, Mn, Co, Ni, Cu, and Zn) have been grown, through which the doping effect on magnetism superconductivity is studied. Elementary analysis reveals that smaller ionic radii for valence state 2+, can substitute effectively Fe levels near 5%. In contrast, solid solution of Zn in host system low. Magnetic electronic investigations show substitution or Cu leads to formation spin-glass suppression superconductivity....
Various Fe-vacancy orders have been reported in tetragonal $\ensuremath{\beta}\ensuremath{-}\mathrm{F}{\mathrm{e}}_{1\ensuremath{-}x}\mathrm{Se}$ single crystals and nanowires/nanosheets, which are similar to those found alkali-metal intercalated ${\mathrm{A}}_{1\ensuremath{-}x}\mathrm{F}{\mathrm{e}}_{2\ensuremath{-}y}\mathrm{S}{\mathrm{e}}_{2}$ superconductors. Here we report the situ angle-resolved photoemission spectroscopy study of disordered ordered phases FeSe multilayer thin films...
Two new monoterpenoid glycosides, trans-1,8-cineole-3,6-dihydroxy-3-O-β-D-glucopyranoside (1), and 5,9-dihydroxy borneol 2-O-β-D-glucopyranoside (2), together with four known glycosides (3-6), were isolated from the water-soluble constituents of fresh rhizome Tongling White Ginger (Zingiber officinale). Their structures decisively elucidated by spectroscopic analysis. In vitro tests for antimicrobial activity showed that compounds 1 3 possess significant against two Gram-positive organisms,...
We have investigated the pressure effect on superconductivity of Fe1+yTe1−xSx single crystals. show that applied leads to opposite variation in between homogeneous and inhomogeneous samples. With increasing 10 kbar, homogenous sample S1 is suppressed gradually, however Tcmag S4 can be raised up 21 K. The increase believed as stabilizing structure by strain sample, thereby avoiding structural transition under pressure. Our results imply higher Tc could expected iron chalcogenides if this...
We have studied the low-lying electronic structure of a new ${\mathrm{ThCr}}_{2}{\mathrm{Si}}_{2}$-type superconductor ${\mathrm{KNi}}_{2}{\mathrm{Se}}_{2}$ with angle-resolved photoemission spectroscopy. Three bands intersect Fermi level, forming complicated surface topology, which is sharply different from its isostructural ${\mathrm{K}}_{x}\mathrm{Fe}{\phantom{\rule{0.16em}{0ex}}}_{2\ensuremath{-}y}{\mathrm{Se}}_{2}$. The shows weak variation along ${k}_{z}$ direction, indicating...