Abstract Background Fibroblast-like synoviocytes (FLS) are crucial for maintaining synovial homeostasis. SMYD5, a member of the histone lysine methyltransferase subfamily SMYDs, is involved in many pathological processes. This study aimed to investigate role SMYD5 regulating fibroblast homeostasis and pathogenesis rheumatoid arthritis (RA). Methods Proteomic screening was conducted assess expression synovium patients with osteoarthritis (OA) RA. In vitro, interleukin-1 beta (IL-1β) used...

Abstract Background The blood‐brain barrier (BBB) plays a principal role in the healthy and diseased central nervous systems, BBB disruption after ischaemic stroke is responsible for increased mortality. Smyd2, member of SMYD‐methyltransferase family, vital disease by methylation diverse substrates; however, little known about its pathophysiology brain response to ischaemia‐reperfusion injury. Methods Using oxygen glucose deprivation reoxygenation (OGD/R)‐induced primary microvascular...

In this article, a PZT/Epoxy 1-3 piezoelectric composite based on picosecond laser etching technology is developed for the fabrication of high-frequency ultrasonic transducer. The design, fabrication, theoretical analysis, and performance piezocomposite transducer are presented discussed. According to test results, area PZT pillar [Formula: see text], average width kerf thickness text]. fabricated has resonant frequency 46.5 MHz, parallel 65 an electromechanical coupling coefficient 0.73....

Due to the small aperture of blood vessel, a considerable disadvantage current intravascular ultrasound (IVUS) imaging transducers is that their lateral resolution much lower than axial resolution. To solve this problem, single-element, 50 MHz, 0.6 mm diameter IVUS transducer with geometric focus at 3 was proposed in paper. The focusing based on geometric-shaped 1-3 piezocomposite. impedance/phase, pulse echo, acoustic intensity field, and were tested. For comparison, flat same...

Chirp coded excitation is an effective method to improve the signal-to-noise ratio (SNR) and penetration depth of high-frequency endoscopic ultrasound (EUS) imaging. In excitation, pulse compression applied compress elongated signals into a short pulse, which determines final imaging performance, including spatial resolution SNR. However, with current methods, it hard get high performance in peak sidelobe level (PSL), image contrast, axial at same time. To solve this problem, article, new...

Transmission cable has great influence upon the performance of high-frequency ultrasound transducers, especially for those intrusive applications, where front-end tuning circuits are unavailable. In this paper, a method modeling transducers by considering effect was proposed based on transmission line theory. A full examination various cables effects were achieved through model. Typical transducer characteristics, including output impedance and pulse-echo response attained good agreement...

The equivalent circuit simulation plays an important role in the design of ultrasound transducer. However, existing methods are difficult to achieve effect matching and backing layer, not able accurately simulate transducer with cable. Especially application high frequency ultrasound, long cable has a great influence on performance To overcome these limitations, this paper proposed improved method, which combined Leach model transmission line model. It can realize complete cable, layer...

High-frequency ultrasound has developed rapidly in clinical fields such as cardiovascular, ophthalmology, and skin with its high imaging resolution. However, the development of multi-elements high-frequency ultrasonic transducers multi-channel systems is extremely challenging. Here, a system based on mechanical scanning was proposed this paper. It adopts method reciprocating feed mechanism, which can achieve 14 mm range at 168 mm/s small 60 MHz transducer. A single-channel consisting...

Intravascular ultrasound has good prospects for clinical applications in sonothrombolysis. The catheter-based side-looking intravascular thrombolysis (e.g., Ekosonic catheters) used studies a high frequency (2 MHz). lower-frequency requires larger-diameter transducer. In our study, we designed and manufactured small ultrasound-based prototype catheter that can emit lower (1.1 order to evaluate the safety efficacy of local low-frequency ultrasound-enhanced thrombolysis, microbubble (MB) was...

Purpose The catheter-based ultrasound (CBUS) can reach the target tissue directly and achieve rapid treatment. frequency shift keying (FSK) signal is proposed to regulate evaluate tumor ablation by a miniaturized dual-frequency transducer.Methods A transducer prototype (3 × 7 0.4 mm) was designed fabricated for CBUS applicator (OD: 3.8 based on fundamental of 5.21 MHz third harmonic 16.88 MHz. Then, acoustic fields temperature field distributions using FSK signals (with 0, 25, 50, 75, 100%...

This paper presents a single piezoelectric transducer with dual-frequency characters by utilizing contour-extensional mode and thickness mode. A 2.5 MHz 8.5 frequency prototype is designed Finite element method (FEM) analyses verified experiment. Performance of the then evaluated through measurement admittance curves pulse-echo responses. It’s demonstrated experimentally that proposed has -6dB bandwidth 39.4% @1.0 Vpp at 2.4 34.6% @1.1 8.9 MHz, respectively. The potential applications in...

Ischemic stroke is known to cause the accumulation of misfolded proteins and loss calcium homeostasis, leading impairment endoplasmic reticulum (ER) function activating unfolded protein response (UPR). PARP16 an active (ADP-ribosyl)transferase tail-anchored ER transmembrane with a cytosolic catalytic domain. Here, we find highly expressed in ischemic cerebral hemisphere oxygen-glucose deprivation/reoxygenation (OGD/R)-treated immortalized hippocampal neuronal cell HT22. Using...

15-15Ti is one of the potential candidate materials for fuel rod cladding lead-based reactors, and its fatigue properties have been investigated. Low cycle (LCF) tests carried out under total strain amplitudes ranging from ±0.3% to ±0.9% at 20 550°C in vacuum. The results show LCF life decreases with increase temperature. Crack propagates more tortuously crack propagation (FCP) rate lower when it tested 20°C compared 550°C. In addition, effect twin boundaries (TBs) stacking fault energy...

Abstract The measurement of shear wave speed (SWS) or attenuation in soft materials, especially biological tissues, plays a crucial role acoustic radiation force elasticity imaging which provides quantitative elastic properties. In this study, with the first attempt to apply modal analysis theory imaging, we propose fast tracking algorithm based on assurance criterion (MAC) including 2D SWS-MAC for SWS and signed cross (CrossMAC) measurement. These approaches achieved high speedup framework...

Background: Vascular aging is one of the important factors contributing to pathogenesis cardiovascular diseases. However, systematic epigenetic regulatory mechanisms during vascular are still unclear. Histone methyltransferase SET and MYND domain-containing protein 2 (Smyd2) associated with multiple diseases including cancer inflammatory diseases, but whether it involved in endothelial cell senescence aging-related has not been directly proved. Thus, we aim address effects Smyd2 on...

Endoscopic transducer with small size and high frequency has been widely studied applied in medical ultrasound imaging. However, attenuation affects waves to a greater degree than lower waves, which results limited endoscopic detection depth poor signal-to-noise ratio the image. High sensitivity is an effective way improve this problem. In paper, (HSEUST) integrated miniature amplifier was proposed, where can effectively enhance received signal reduce impact of noise. According tests...

We present a united coherence factor beamformer for coherent plane-wave compounding (CPWC). CPWC is capable to reach an image quality comparable the conventional B-mode imaging with much higher frame rate and could be further applied Doppler imaging. Conventional (CF) based beamformers use only either spatial or angular information, which limits quality. To take full advantage of radio frequency (RF) data better quality, this paper proposes (uCF) using both information CPWC. The proposed uCF...

A practical intravascular ultrasound system prototype is presented. The designed to work in compliance with high frequency interventional imaging catheter, which has a center as 60MHz. Differ from former architecture, graphic processing unit utilized primary component accomplish most of the crucial computations this machine, based on which, real time algorithm verification becomes much easier. This paper explains motivation start project, introduces hardware architecture that have been...