A5014380715- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Advanced Proteomics Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Prostate Cancer Treatment and Research
- Cell Adhesion Molecules Research
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Treatments and Studies
- Metabolism, Diabetes, and Cancer
Affiliated Hospital of Southwest Medical University
2022-2024
Fudan University Shanghai Cancer Center
2017-2023
Fudan University
2018-2022
Zhongshan Hospital
2022
State Key Laboratory of Genetic Engineering
2022
ORCID
2021
Obstetrics and Gynecology Hospital of Fudan University
2019
Shanghai Medical College of Fudan University
2019
Abstract Clear cell renal carcinoma (ccRCC) is a common and aggressive subtype of cancer. Here we conduct comprehensive proteogenomic analysis 232 tumor adjacent non-tumor tissue pairs from Chinese ccRCC patients. By comparing with tissues, find that shows extensive metabolic dysregulation an enhanced immune response. Molecular subtyping classifies tumors into three subtypes (GP1–3), among which the most GP1 exhibits strongest phenotype, increased metastasis, imbalance, linking...
Abstract The tumorigenic role and underlying mechanisms of lipid accumulation, commonly observed in many cancers, remain insufficiently understood. In this study, we identified an AMP-activated protein kinase (AMPK)–GATA-binding 3 (GATA3)–enoyl-CoA hydratase short-chain 1 (ECHS1) pathway that induces accumulation promotes cell proliferation clear renal carcinoma (ccRCC). Decreased expression ECHS1, which is responsible for inactivation fatty acid (FA) oxidation activation de novo FA...
Abstract Background Urothelial carcinoma (UC) is the most common pathological type of bladder cancer, a malignant tumor. However, an integrated multi-omics analysis Chinese UC patient cohort lacking. Methods We performed analysis, including whole-exome sequencing, RNA-seq, proteomic, and phosphoproteomic 116 patients, comprising 45 non-muscle-invasive cancer patients (NMIBCs) 71 muscle-invasive (MIBCs). Result Proteogenomic integration indicated that SND1 CDK5 amplifications on chromosome 7q...
Abstract Chemotherapy and targeted therapy are the major treatments for gastric cancer (GC), but drug resistance limits its effectiveness. Here, we profile proteome of 206 tumor tissues from patients with GC undergoing either chemotherapy or anti-HER2-based therapy. Proteome-based classification reveals four subtypes (G-I–G-IV) related to different clinical molecular features. MSI-sig high benefit docetaxel combination treatment, accompanied by anticancer immune response. Further study T...
Abstract The KEAP1-NRF2 axis is the principal regulator of cellular responses to oxidative and electrophilic stressors. NRF2 hyperactivation frequently observed in many types cancer promotes initiation, progression, metastasis, resistance various therapies. Here, we determined that dipeptidyl peptidase 9 (DPP9) a pathway clear cell renal carcinoma (ccRCC). DPP9 was markedly overexpressed at mRNA protein levels ccRCC, high expression correlated with advanced tumor stage poor prognosis...
Abstract Esophageal squamous cell carcinoma (ESCC) is malignant while the carcinogenesis still unclear. Here, we perform a comprehensive multi-omics analysis of 786 trace-tumor-samples from 154 ESCC patients, covering 9 histopathological stages and 3 phases. Proteogenomics elucidates cancer-driving waves in progression, reveals molecular characterization alcohol drinking habit associated signatures. We discover chromosome 3q gain functions transmit nontumor to intraepithelial neoplasia...
Abstract Accumulation of nucleotide building blocks prior to and during S phase facilitates DNA duplication. Herein, we find that the anaphase-promoting complex/cyclosome (APC/C) synchronizes ribose-5-phosphate levels synthesis cell cycle. In late G 1 phases, transketolase-like (TKTL1) is overexpressed forms stable TKTL1-transketolase heterodimers accumulate ribose-5-phosphate. This accumulation occurs by asymmetric production from non-oxidative pentose phosphate pathway prevention removal...
Abstract Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is a rare type of kidney cancer, which not well characterized. Here we show the comprehensive proteogenomic analysis tRCC tumors and normal adjacent tissues to elucidate molecular landscape this disease. Our study reveals that defective DNA repair plays an important role in carcinogenesis progression. Metabolic processes are markedly dysregulated at both mRNA protein levels. Proteomic...
Next-generation sequencing of the exome and genome prostate cancers has identified numerous genetic alterations. SPOP (Speckle-type POZ Protein) is one most frequently mutated genes in primary cancer, suggesting that may be a potential driver cancer. The aim this work was to investigate how mutations contribute cancer development progression.To identify molecular mediators tumor suppressive function SPOP, we performed yeast two-hybrid screen HeLa cDNA library using full-length as bait....
Objective This study aims to identify potential prognostic and therapeutic biomarkers in papillary renal cell carcinoma (pRCC).Methods Two microarray datasets were downloaded from the Gene Expression Omnibus (GEO) database differentially expressed genes (DEGs) identified. The protein-protein interaction (PPI) networks functional annotations of DEGs established. Survival analysis was utilized evaluate significance association between expression level candidate various tumour-infiltrating...
Clear cell renal carcinoma (ccRCC) is the most common adult neoplasm and its incidence continues to increase. Collagen abundant extracellular matrix protein in stroma, contributes development progression of ccRCC. We examined human collagen type XXIII α1 chain (COL23A1) expression ccRCC relationship between COL23A1 patients' survival. found mRNA was elevated tumor compared with adjacent normal tissues, which further validated by TCGA cohort. IHC results from 151 cases suggested that high...
Abstract The tyrosine kinase inhibitor (TKI) Sunitinib is one the therapies approved for advanced renal cell carcinoma. Here, we undertake proteogenomic profiling of 115 tumors from patients with clear carcinoma (ccRCC) undergoing treatment and reveal molecular basis differential clinical outcomes TKI therapy. We find that chromosome 7q gain-induced mTOR signaling activation associated poor therapeutic treatment, whereas aristolochic acid signature VHL mutation synergistically caused...
Among all types of renal cancer, clear cell carcinoma (ccRCC) is the most common and lethal subtype associated with a high risk metastasis recurrence. Histone modifications regulate several biological processes that are fundamental to development cancer. Lysine methyltransferase 5C (KMT5C; also known as SUV420H2) an epigenetic modifier responsible for trimethylation H4K20, which drives critical cellular events, including genome integrity, growth epithelial‑mesenchymal transition (EMT), in...
Tribbles homolog 3 (TRIB3), a pseudokinase that regulates multiple intracellular signaling pathways, has been reported to promote the growth of tumors. However, its role in clear cell renal carcinoma (ccRCC) remains unelucidated. We evaluated TRIB3 ccRCC using publicly available data from The Cancer Genome Atlas and analyzed relationship with tumor microenvironment; moreover, we used gene knockout overexpression techniques detect effects on biological behavior cells. RT-qPCR western blotting...
OBJECTIVE: To investigate the association between tumor PD-L1 expression and patient survival to determine whether represents an independent prognostic feature for patients with nonmetastatic clear cell renal carcinoma. PATIENTS AND METHODS: Tissue bank of Fudan University Shanghai Cancer Center was queried identity tissue samples treated radical nephrectomy sporadic carcinoma during period 2008 2015. Real-time polymerase chain reaction immunohistochemistry staining performed detect level in...
<div>Abstract<p>The KEAP1-NRF2 axis is the principal regulator of cellular responses to oxidative and electrophilic stressors. NRF2 hyperactivation frequently observed in many types cancer promotes initiation, progression, metastasis, resistance various therapies. Here, we determined that dipeptidyl peptidase 9 (DPP9) a pathway clear cell renal carcinoma (ccRCC). DPP9 was markedly overexpressed at mRNA protein levels ccRCC, high expression correlated with advanced tumor stage...
Background: In the past decade, immunotherapy has been widely used in treatment of various tumors, such as PD-1/PD-L1 inhibitors. Although clear cell renal carcinoma (ccRCC) shown to be sensitive immunotherapy, it is effective only several cases, which brings great obstacles anti-tumor therapy for patients. Lawson et al. have successfully identified 182 “core cancer innate immune escape genes” whose deletion makes cells more or resistant T-cell attack. Methods: this research, we sought...
Background: Specific lifestyle factors including tobacco-exposure are vital etiologic for renal cell carcinoma (RCC), F2R Like Thrombin/Trypsin Receptor 3 (F2RL3) is associated with smoking but it unknown whether its expression translate into poor survival of clear RCC (ccRCC). In the current study, profiling and prognostic value F2RL3 in Chinese patients ccRCC were investigated. Methods: Using Quantitative PCR analysis immunohistochemistry, relative levels 367 paired adjacent normal tissues...
Liver hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and POLE, playing an important role in maintaining genetic stability, closely connected with cancer prognosis. This study aimed to explore significance POLE HCC prognosis, clinical treatment tumor immune microenvironment based on large-scale multiply cohorts.
Abstract We performed a comprehensive genomic, proteomic, and phosphoproteomic analysis of 756 trace-tumor-samples from 124 esophageal cancer (EC) patients, covering 9 major histopathological stages 22 substages. The results revealed significant diversity proteome patterns in the integrated multi-omics data identified genomic-proteomic aberrations revealing association TP53, ATM, EP400 mutations that affected cell cycle, DNA repair, glycolysis, with poor prognosis. Proteome-based elucidated...
<div>Abstract<p>The KEAP1-NRF2 axis is the principal regulator of cellular responses to oxidative and electrophilic stressors. NRF2 hyperactivation frequently observed in many types cancer promotes initiation, progression, metastasis, resistance various therapies. Here, we determined that dipeptidyl peptidase 9 (DPP9) a pathway clear cell renal carcinoma (ccRCC). DPP9 was markedly overexpressed at mRNA protein levels ccRCC, high expression correlated with advanced tumor stage...