A5034574218- Renal cell carcinoma treatment
- SARS-CoV-2 detection and testing
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Hedgehog Signaling Pathway Studies
- Cancer-related molecular mechanisms research
- COVID-19 diagnosis using AI
- Genomics and Chromatin Dynamics
- Immune Response and Inflammation
- Bladder and Urothelial Cancer Treatments
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Renal and related cancers
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Infection Control and Ventilation
- Cell Adhesion Molecules Research
- Structural Behavior of Reinforced Concrete
- Inflammatory Biomarkers in Disease Prognosis
Union Hospital
2024-2025
Huazhong University of Science and Technology
2024-2025
Hunan University of Humanities, Science and Technology
2024
Qinghai University Affiliated Hospital
2023
Shanghai Medical College of Fudan University
2010-2021
Fudan University Shanghai Cancer Center
2010-2021
Nanchang Hangkong University
2021
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2019
Shanghai University of Traditional Chinese Medicine
2019
Shenzhen University Health Science Center
2019
A worldwide outbreak of severe acute respiratory syndrome (SARS) had been reported. Over 8439 SARS cases and 812 SARS-related deaths were reported to the World Health Organization from 32 countries around world up 5 July 2003. The mechanism transmission SARS-CoV has limited only close contacts with patients. Attention was focused on possible by sewage system because laboratory studies showed that patients excreted coronavirus RNA in their stools Amoy Gardens Hong Kong. To explore whether...
The tumor microenvironment (TME) is integral to progression. However, its prognostic implications and underlying mechanisms in clear cell renal carcinoma (ccRCC) are not yet fully elucidated. This study aims examine the significance of genes associated with immune-stromal scores explore their ccRCC. Data from Cancer Genome Atlas (TCGA) International Consortium (ICGC) were subjected analysis compute immune stromal utilizing ESTIMATE algorithm. weighted gene co-expression network (WGCNA) was...
A 2009 global influenza pandemic caused by a novel swine-origin H1N1 virus has posted an increasing threat of potential the highly pathogenic avian (HPAI) H5N1 virus, driving us to develop vaccine which confers cross-protection against both and viruses. Previously, we have shown that tetra-branched multiple antigenic peptide (MAP) based on extracellular domain M2 protein (M2e) from (H5N1-M2e-MAP) induced strong immune responses different clades HPAI In this report, investigated whether such...
Abstract Background The highly pandemic 2009 influenza A H1N1 virus infection showed distinguished skewed age distribution with majority of and death in children young adults. Although previous exposure to related antigen has been proposed as an explanation, the mechanism protection is still unknown. Methods In this study, murine model different ages were inoculated intranasally (A/Beijing/501/09) susceptibility pathological response investigated. Results Our results that younger mice had...
Abstract HIF-1α has a broad impact on tumors, including enhanced utilization of glucose, tumor cell stemness, migration, metastasis and so on. In pilot study, we found that the expression significantly increased in breast cancer lines tissue samples with higher malignant behaviors decreased luminal subtype cells samples. We analyzed there is one large CpG island promoter around transcription start site, hypermethylation occurred at these CpGs their surrounding non-CpGs sites. Epigenetic...
We evaluated the prognostic value of 8th TNM staging system and assessed a modified N stage incorporating high risk human papillomavirus status in multicenter cohort.Included analysis were 292 patients with M0 penile squamous cell carcinoma from total 6 referral centers. High was examined. The Chinese cohort 230 used to validate propose classification. classification further validated an independent 62 at Moffitt Cancer Center.Median followup 48.9 months. Of 42% had node positive disease. In...
A new homozygous humanized transgenic mouse strain, HLA-A2.1+/+HLA-DP4+/+ hCD4+/+mCD4−/−IAβ−/−β2m−/− (HLA-A2/DP4), was obtained by crossing the previously characterized HLA-A2+/+β2m−/− (A2) and our created HLA-DP4+/+ hCD4+/+mCD4−/−IAβ−/− (DP4) mouse. We confirmed that transgenes (HLA-A2, HLA-DP4, hCD4) inherited from parental A2 DP4 mice are functional in HLA-A2/DP4 mice. After immunizing with a hepatitis B DNA vaccine, virus-specific antibodies, HLA-A2-restricted HLA-DP4-restricted...
Purpose: Aim of this study was to comprehensively analyze BRCA1-associated protein-1 (BAP1) somatic mutation in clear cell renal carcinoma (ccRCC) and explore potential therapeutic pathways molecules. Patients methods: In study, we analyzed 445 ccRCC cases from The Cancer Genome Atlas (TCGA). Comprehensive analysis including survival, transcriptome methylation between BAP1 mutated wild-type performed using bioinformatics tools silico. Pathways molecules related were Database for Annotation,...
Abstract Background Emerging evidences have revealed that long non-coding RNAs (lncRNAs) played critical roles in tumor occurrence and progression. LINC00641 has been reported to be involved the initiation development of several cancers recent years. However, detailed biological role renal cell carcinoma (RCC) remains largely unclear. Methods In this study, expression function were assessed both vitro vivo. Cell proliferation, migration colony formation assay performed explore effect...
Reinforced concrete structures play a pivotal role in island and reef engineering projects. Given the resource constraints typical of regions, substituting traditional manufactured sand aggregate with limestone not only reduces reliance on river but also addresses issue disposing waste slag generated during excavation. However, performance characteristics concrete, particularly its bond strength reinforcing steel, warrant further investigation. This is true for bond–slip behavior...
This study aimed to explore the role of ACSL4 in CD8+ T cell tumor infiltration and outcomes bladder cancer (BLCA) patients after immunotherapy.The correlation between expression immune cells was analyzed using Tumor Immune Estimation Resource database. The prognostic significance BLCA Kaplan-Meier curves. Immunohistochemistry used detect tumors with high low obtained from at Fudan University Shanghai Cancer Center. relationships checkpoint genes response were Genome Atlas IMvigor 210...
Notch3 can act as a tumor suppressor in the breast cancer epithelial cells. Unfortunately, expression is decreased or lost, especially triple-negative (TNBC) cells, and reasons remain unclear. Here, we found was upregulated MDA-MB-231 cells with 5-Aza treatment. Two CpG islands were observed notch3 promoter. Interestingly, bisulfite sequencing exhibited that large amounts of unconverted cytosines not only followed by guanine, but also adenine, cytosine thymine, which implied there...
OBJECTIVE: To investigate the association between tumor PD-L1 expression and patient survival to determine whether represents an independent prognostic feature for patients with nonmetastatic clear cell renal carcinoma. PATIENTS AND METHODS: Tissue bank of Fudan University Shanghai Cancer Center was queried identity tissue samples treated radical nephrectomy sporadic carcinoma during period 2008 2015. Real-time polymerase chain reaction immunohistochemistry staining performed detect level in...