A5101408818- biodegradable polymer synthesis and properties
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Chemotherapy-induced cardiotoxicity and mitigation
- CRISPR and Genetic Engineering
- Ion Transport and Channel Regulation
- Plant biochemistry and biosynthesis
- Potassium and Related Disorders
- Nicotinic Acetylcholine Receptors Study
- Rheumatoid Arthritis Research and Therapies
- Ferroptosis and cancer prognosis
- Microbial Metabolic Engineering and Bioproduction
- Cell death mechanisms and regulation
- Autoimmune and Inflammatory Disorders Research
- Herpesvirus Infections and Treatments
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Ion channel regulation and function
- Mycotoxins in Agriculture and Food
- Hippo pathway signaling and YAP/TAZ
- Polymer composites and self-healing
- Flame retardant materials and properties
- Cancer Cells and Metastasis
- Nitric Oxide and Endothelin Effects
- Epigenetics and DNA Methylation
Nanjing Normal University
2021-2025
Beijing University of Chemical Technology
2024-2025
State Key Laboratory of Microbial Technology
2025
Jinzhou Medical University
2024
Sichuan University
2023
Sixth Affiliated Hospital of Sun Yat-sen University
2019-2022
Sun Yat-sen University
2019-2022
Gansu Provincial Hospital
2019-2022
China Medical University
2020
Shantou University
2018
Abstract Antioxidants play a crucial role in inhibiting polypropylene (PP) oxidative damage and extending polymer lifetime. However, the high migration rate limited efficiency reduced protection, often requiring overdosing, which raises environmental health issues. Herein, more sustainable solution involves an ultrathin antioxidant intercalated layered double hydroxides (LDHs) with chitosan (CS) encapsulation to block antioxidants by tuning CS molecular weight fully encapsulate LDH unit. The...
Exploring and exploiting the catalytic promiscuity of enzymes is a central topic captivating challenge in enzymology. CYP152 peroxygenases are attractive biocatalysts for diverse reactions under mild conditions using H2O2 as cofactor. However, their substrate scope limited by carboxyl group required assisted acid‐base catalysis, following well‐accepted principle that heme‐dependent H2O2‐utilizing employ within active sites to facilitate activation. Herein, we reveal first time several family...
Exploring and exploiting the catalytic promiscuity of enzymes is a central topic captivating challenge in enzymology. CYP152 peroxygenases are attractive biocatalysts for diverse reactions under mild conditions using H2O2 as cofactor. However, their substrate scope limited by carboxyl group required assisted acid‐base catalysis, following well‐accepted principle that heme‐dependent H2O2‐utilizing employ within active sites to facilitate activation. Herein, we reveal first time several family...
Objective It remains unknown whether insulin-like growth factor-1 (IGF-1) can attenuate myocardial ischemia/reperfusion (I/R) injury in vivo by activating the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway. This study investigated possible interaction of IGF-1 with PI3K/Akt pathway cardioprotection against I/R rats. Methods We established a model rats through left anterior descending artery ligation for 40 minutes followed 6 hours reperfusion. The inhibitor, LY294002 (0.3...
Escherichia coli BL21 (DE3) is the most widely used host for recombinant protein expression. However, not every can be highly expressed in (DE3), so individual optimization strategies are often required different proteins, which time-consuming and difficult to apply rapidly industrial production. Constructing more hosts a good choice enrich expression selection. The level of T7 RNAP core control node pET system, regulating its an effective way improving production difficult-to-express...
Isotope-labeling-based mass spectrometry (MS) is widely used in quantitative proteomic studies. With this technique, the relative abundance of thousands proteins can be efficiently profiled parallel, greatly facilitating detection differentially expressed across samples. However, task remains computationally challenging. Here we present a new approach, termed Model-based Analysis Proteomic data (MAP), for task. Unlike many existing methods, MAP does not require technical replicates to model...
To compare the effects of two biologic disease-modifying antirheumatic drug (bDMARD) administration strategies on maintenance effect and safety patients with rheumatoid arthritis (RA) in remission, to analyze gradual reduction dose treatment clinical outcomes who have achieved remission different types bDMARDs, search screen out people may benefit from strategies, provide references for options RA so as help improve reduce economic burden.The study will be a 24-month non-inferiority...