A5086248772- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA modifications and cancer
- Cardiac electrophysiology and arrhythmias
- Neurological disorders and treatments
- Tissue Engineering and Regenerative Medicine
- PI3K/AKT/mTOR signaling in cancer
- Genomics and Phylogenetic Studies
- Protein Degradation and Inhibitors
- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Advances in Cucurbitaceae Research
- Protease and Inhibitor Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Chromosomal and Genetic Variations
- Cancer Cells and Metastasis
- Inflammatory Biomarkers in Disease Prognosis
- Bone and Joint Diseases
- Bone and Dental Protein Studies
- Infectious Diseases and Mycology
- Chemokine receptors and signaling
- Peptidase Inhibition and Analysis
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
Guangzhou Medical University
2022-2024
Huizhou University
2024
Third Affiliated Hospital of Guangzhou Medical University
2022
Shantou University
2018-2020
Cancer Hospital of Shantou University Medical College
2018-2020
Institut de génétique et de biologie moléculaire et cellulaire
2013
Inserm
2013
Université de Strasbourg
2013
Johns Hopkins University
2011
Abstract To decipher the genetic diversity within cucurbit genus Citrullus , we generated telomere-to-telomere (T2T) assemblies of 27 distinct genotypes, encompassing all seven species. This T2T super-pangenome has expanded previously published reference genome, T2T-G42, by adding 399.2 Mb and 11,225 genes. Comparative analysis unveiled gene variants structural variations (SVs), shedding light on watermelon evolution domestication processes that enhanced attributes such as bitterness sugar...
Genetic alterations of 16q21-q22, the locus a 6-cadherin cluster, are frequently involved in multiple tumors, suggesting presence critical tumor suppressor genes (TSGs). Using 1 Mb array comparative genomic hybridization (aCGH), we refined small hemizygous deletion (∼1 Mb) at 16q21-22.1, which contains single gene Cadherin-11 (CDH11, OB-cadherin). CDH11 was broadly expressed human normal adult and fetal tissues, while its silencing promoter CpG methylation were detected cell lines, but not...
Abstract HIF-1α has a broad impact on tumors, including enhanced utilization of glucose, tumor cell stemness, migration, metastasis and so on. In pilot study, we found that the expression significantly increased in breast cancer lines tissue samples with higher malignant behaviors decreased luminal subtype cells samples. We analyzed there is one large CpG island promoter around transcription start site, hypermethylation occurred at these CpGs their surrounding non-CpGs sites. Epigenetic...
MMP-11 is a bad prognosis paracrine factor in invasive breast cancers. However, its mammary physiological function remains largely unknown. In the present study we have investigated during postnatal gland development and using MMP-11-deficient (MMP-11−/−) mice. Histological immunohistochemical analyses as well whole-mount staining show alteration of absence MMP-11, where ductal tree, alveolar structures milk production are reduced. Moreover, series transplantation experiments allowed us to...
Adipocytes constitute a major component of the tumour microenvironment. Numerous studies have shown that adipocytes promote aggressiveness and invasion by stimulating cancer cells proliferation modulating their metabolism. Herein, we reported Notch3 promotes mouse 3T3-L1 pre-adipocytes differentiation performing integrative transcriptome TMT-based proteomic analyses. The results revealed aminoacyl-tRNA_biosynthesis pathway was significantly influenced with Nocth3 change during...
Our previous study found that Notch3 knockout mice exhibit defects in mammary gland development. To elucidate the underlaying mechanism, tissue samples were subjected to RNA-seq, GO, KEGG enrichment analyses and qRT-PCR validation. Of enriched pathways, chemokine signaling pathway cytokine-cytokine receptor interaction noticed both Notch3wt/wt/Notch3wt/- Notch3wt/wt/Notch3-/- mice. In which, expression of ligand 2 (CCL2) was sharply reduced Notch3wt/- Notch3-/- tissues. The Mouse ENCODE...
Notch3 can act as a tumor suppressor in the breast cancer epithelial cells. Unfortunately, expression is decreased or lost, especially triple-negative (TNBC) cells, and reasons remain unclear. Here, we found was upregulated MDA-MB-231 cells with 5-Aza treatment. Two CpG islands were observed notch3 promoter. Interestingly, bisulfite sequencing exhibited that large amounts of unconverted cytosines not only followed by guanine, but also adenine, cytosine thymine, which implied there...
Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens , has good anti-leukemia effect, but its key target and mechanism remains unclear. Here, we found only c-Myc could respond rapidly to matrine treatment in three myeloid leukemia cell lines, inhibited both transcription translation of c-Myc. Ribosome biogenesis nucleotide metabolism, downstream c-Myc, were significantly suppressed after treatment. Therefore, our results confirmed is special...
EMT allows a polarized epithelium to lose epithelial integrity and acquire mesenchymal characteristics. Previously, we found that overexpression of the intracellular domain Notch3 (N3ICD) can inhibit in breast cancer cells. In this study, aimed elucidate influence N3ICD or combined with transmembrane (TD+N3ICD) on expression distribution TJs/AJs polar molecules. We although upregulate levels above-mentioned molecules, TD+N3ICD more effectively than alone. upregulated endogenous full-length...