A5103217691- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Dietary Effects on Health
- Circadian rhythm and melatonin
- Cancer, Hypoxia, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
Fudan University Shanghai Cancer Center
2025
China Pharmaceutical University
2024-2025
The major histocompatibility complex class I (MHC I)-mediated tumor antigen processing and presentation (APP) pathway is essential for the recruitment activation of cytotoxic CD8
<title>Abstract</title> Gemcitabine resistance is a critical factor contributing to the recurrence and progression of bladder cancer. In this study, we utilized high-throughput drug screening cancer organoid models identify Bavachalcone (Bava) as sensitizing agent for gemcitabine, thereby inhibiting Bava targets transferrin receptor (TFRC) epidermal growth (EGFR), competitively binding TFRC with (Tf), which reduces influx iron ions activity mitochondrial respiratory chain complexes....
Ferroptosis is a form of nonapoptotic cell death characterized by iron-dependent peroxidation polyunsaturated phospholipids. However, much remains unknown about the regulators ferroptosis. Here, using CRISPR-Cas9-mediated genetic screening, we identify protein arginine methyltransferase 1 (PRMT1) as crucial promoter We find that PRMT1 decreases expression solute carrier family 7 member 11 (SLC7A11) to limit abundance intracellular glutathione (GSH). Moreover, show interacts with ferroptosis...
The clinical success of KRAS