A5064807549- Water Treatment and Disinfection
- Chemical and Physical Properties in Aqueous Solutions
- Protein Structure and Dynamics
- Analytical Chemistry and Chromatography
- X-ray Diffraction in Crystallography
- Chemical Thermodynamics and Molecular Structure
- Enzyme Structure and Function
- Advanced NMR Techniques and Applications
- Crystallization and Solubility Studies
- Irrigation Practices and Water Management
- Wastewater Treatment and Nitrogen Removal
- Minerals Flotation and Separation Techniques
- Urban Stormwater Management Solutions
- Chromatography in Natural Products
- thermodynamics and calorimetric analyses
- Mass Spectrometry Techniques and Applications
- Crystallography and molecular interactions
- Solid-state spectroscopy and crystallography
- Water Quality Monitoring Technologies
- Electrochemical sensors and biosensors
- Natural product bioactivities and synthesis
- DNA and Nucleic Acid Chemistry
- Constructed Wetlands for Wastewater Treatment
- RNA modifications and cancer
- Bacterial biofilms and quorum sensing
The University of Texas Medical Branch at Galveston
2011-2025
Tianjin University
2021-2025
China Pharmaceutical University
2024-2025
Panzhihua University
2024
Daqing Oilfield General Hospital
2024
Nanjing University of Science and Technology
2024
Lanzhou University
2024
State Key Laboratory of Marine Geology
2023
Tongji University
2023
China Agricultural University
2013-2022
RNA aptamers are synthetic oligonucleotide-based affinity molecules that utilize unique three-dimensional structures for their and specificity to a target such as protein. They hold the promise of numerous advantages over biologically produced antibodies; however, binding often insufficient successful implementation in diagnostic assays or therapeutic agents. Strong is important improve downstream applications. We report here use phosphorodithioate (PS2) substitution on single nucleotide...
The major histocompatibility complex class I (MHC I)-mediated tumor antigen processing and presentation (APP) pathway is essential for the recruitment activation of cytotoxic CD8
Micro–nanobubbles (MNBs) can generate ·OH in situ, which provides a new idea for the safe and efficient removal of pollutants water supply systems. However, due to difficulty obtaining stable MNBs, generation efficiency is low, cannot be guaranteed. This paper reviews application research MNB technology security from three aspects: process MNBs water, rule during collapse, control mechanisms on biofilms. We found that methods are divided into chemical mechanical (about 10 kinds) categories,...
Significance Bacteria stimulate host cells in part via secreted products, some of which are packaged membrane vesicles (MV). MV released by the major human pathogen Mycobacterium tuberculosis (Mtb) carry lipoprotein LpqH, a agonist for Toll-like receptor 2 (TLR2). This study identifies gene, rv0431 , appears to regulate mycobacterial formation, and therefore we suggest it be named “vesiculogenesis immune response regulator” ( virR ). gene encodes protein that includes unique fold, as...
Despite their importance in macromolecular interactions and functions, the dynamics of lysine side-chain amino groups proteins are not well understood. In this study, we have developed methodology for investigations NH3(+) by NMR spectroscopy computation. By using 1H−15N heteronuclear correlation experiments optimized 15NH3(+) moieties, analyzed dynamic behavior individual human ubiquitin at 2 °C pH 5. We modified theoretical framework previously CH3 used it to analyze 15N relaxation data...
Efficient and concise synthetic approaches have been developed for the rapid diverse installation of azide functionalities at C-1, C-2, or C-3 positions oridonin (1) with highly controlled regio- stereoselectivity, while keeping key reactive pharmacophores intact by utilizing unique preactivation strategies based on common synthon 4. Further functionalization these azides through click chemistry yielding triazole derivatives successfully provides access to an expanded natural scaffold-based...
Chemically synthesized small interfering RNAs (siRNAs) have been widely used to identify gene function and hold great potential in providing a new class of therapeutics. Chemical modifications are desired for therapeutic applications improve siRNA efficacy. Appropriately protected ribonucleoside-3′-yl S-[β-(benzoylmercapto)ethyl]pyrrolidino-thiophosphoramidite monomers were prepared the synthesis containing phosphorodithioate (PS2) substitutions which two non-bridging oxygen atoms replaced...
A mild and concise approach for the construction of a 3,4-dihydro-2<italic>H</italic>-pyran ring integrated into A-ring natural product oridonin is reported herein.
Abstract Exhaled breath analysis has emerged as a promising non-invasive method for diagnosing lung cancer (LC), whereas reliable biomarkers are lacking. Herein, standardized and systematic study was presented LC diagnosis, classification metabolism exploration. To improve the reliability of biomarkers, validation group included, quality control sampling analysis, comprehensive pollutants strict biomarker screening were performed. The performance exhaled shown to be excellent in even early...
Biofilm growth in drinking water distribution systems (DWDS) has become a concern due to various quality issues. Suitable disinfection methods are required ensure safety. Micro-nano bubbles...
Although nuclear magnetic resonance (NMR) spectroscopy is powerful for protein dynamics investigations, the anisotropy of internal motions has been difficult to analyze with NMR. In principle, NMR order parameters multiple bond vectors fixed on same plane can reveal motions. We investigated anisotropic asparagine (Asn) and glutamine (Gln) side chain NH2 groups using 2H 15N relaxation rates. Hindered rotations about C-N causing chemical exchange between two hydrogens Asn/Gln are far slower...
Amino acid side chains involved in hydrogen bonds and electrostatic interactions are crucial for protein function. However, detailed investigations of such solution rare. Here, through the combination long-range (15)N-(13)C scalar J-coupling measurements an atomic-detail molecular dynamics (MD) simulation, direct insight into structural dynamic behavior lysine human ubiquitin has been gained. On basis (1)H/(13)C/(15)N heteronuclear correlation experiments selective NH(3)(+) groups, we...
Micro nano bubbles (MNBs) can generate ·OH in situ, which provides a new idea for the safe and efficient removal of pollutants water supply systems. However, difficulty obtaining stable MNBs causes low efficiency generation, makes inability to guarantee pollutants. This paper reviews application research technology security from three aspects: generation process water, rule during collapse, control mechanism on biofilms. We found that methods are divided into chemical mechanical (about 10...
In order to evaluate the physical and chemical properties of polymer surfactants analyze their oil displacement mechanisms, three types poly-surfactant used in Daqing field were chosen be researched, effects studied using poly-surfactants different viscosity, dehydrating rate, core permeability. The main purpose is determine reasonable range characteristic indexes polymeric surfactant flooding. effect 15 cores was analyzed, rate emulsion, permeability on EOR (Enhanced Oil Recovery) analyzed....
Ferroptosis is a form of nonapoptotic cell death characterized by iron-dependent peroxidation polyunsaturated phospholipids. However, much remains unknown about the regulators ferroptosis. Here, using CRISPR-Cas9-mediated genetic screening, we identify protein arginine methyltransferase 1 (PRMT1) as crucial promoter We find that PRMT1 decreases expression solute carrier family 7 member 11 (SLC7A11) to limit abundance intracellular glutathione (GSH). Moreover, show interacts with ferroptosis...