A5007576118- Traditional Chinese Medicine Studies
- Cryptography and Data Security
- Rheumatoid Arthritis Research and Therapies
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- DNA Repair Mechanisms
- Cell Adhesion Molecules Research
- Pharmacological Effects of Natural Compounds
- Listeria monocytogenes in Food Safety
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Genetic factors in colorectal cancer
- Cell death mechanisms and regulation
- Medical Research and Treatments
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Extracellular vesicles in disease
- Systemic Lupus Erythematosus Research
- Cancer, Hypoxia, and Metabolism
- Molecular Biology Techniques and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Healthcare and Venom Research
- HIV Research and Treatment
Northwest A&F University
2023-2025
Zunyi Medical University
2025
Huazhong University of Science and Technology
2015-2024
Shanghai First People's Hospital
2024
Shanghai Jiao Tong University
2024
China Pharmaceutical University
2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2005-2023
Shanghai University of Traditional Chinese Medicine
2005-2023
Fujian Provincial Cancer Hospital
2023
University of Chinese Academy of Sciences
2022
Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control cell adhesions junctions), migration, polarization. Through its interaction with other proteins, Rap1 plays many roles during invasion metastasis different cancers. The function straightforward; it acts as switch signaling transduction regulated by binding to either guanosine triphosphate (GTP) or diphosphate (GDP). However,...
The distant metastasis of cancer cells is a risk factor for tumor lethality and poor prognosis in non-small-cell lung carcinoma (NSCLC). Increased SOX9 expression has been associated with clinical stage NSCLC, but the molecular mechanisms by which promotes NSCLC are still unknown.The relationship between T, N, M classification was assessed using χ2 test Spearman's analysis 142 immunohistochemically diagnosed specimens NSCLC. We also generated SOX9-overexpression SOX9-knockdown lines their...
Copper nanoclusters (CuNCs) exhibit susceptibility to oxidation in the subnanometer size range.
Studies have begun to emerge showing the protumor effects of tumor-associated neutrophils (TANs) in tumorigenesis, which may involve dysfunction NK cells. However, mechanism through these rebellious modulate cell immunity tumor-bearing state remains unclear. In present study, we demonstrate that can impair cytotoxicity and infiltration capability cells, downregulate CCR1 resulting weakened Moreover, decrease responsiveness NK-activating receptors, NKp46 NKG2D. Mechanistically, enhanced PD-L1...
The major histocompatibility complex class I (MHC I)-mediated tumor antigen processing and presentation (APP) pathway is essential for the recruitment activation of cytotoxic CD8
Transendothelial migration of malignant cells plays an essential role in tumor progression and metastasis. The present study revealed that treating human umbilical vein endothelial (HUVECs) with exosomes derived from metastatic breast cancer increased the number migrating through cell layer impaired tube formation HUVECs. Furthermore, expression intercellular junction proteins, including vascular cadherin (VE-cadherin) zona occluden-1 (ZO-1), was reduced significantly HUVECs treated...
Degradation mechanism of the K–Fe/oxalic acid/H<sub>2</sub>O<sub>2</sub>/visible light system.
In the present study, we showed that SPA-1, a Rap1 GTPase-activating protein (GAP), was bound to cytoskeleton-anchoring AF-6. SPA-1 and AF-6 were co-immunoprecipitated in 293T cells transfected with both cDNAs as well normal thymocytes. vitro binding studies using truncated fragments their mutants suggested PDZ domain of via probable internal ligand motif within GAP-related domain. The conserved among GAPs, it shown rapGAP I comparably SPA-1. RapV12 also N-terminal domain, only presence...
Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer, and its underlying molecular mechanisms are poorly understood. Recent large-scale genome-wide association studies in Chinese Han populations have identified an ESCC susceptibility locus within the SLC39A6 gene. Here, we sought to explore expression biological function of ESCC.Multiethnic validation protein was performed different cohorts patients from Kazakh Xinjiang region by immunohistochemistry. The associations among...
Increased dependence on aerobic glycolysis is characteristic of most cancer cells, whereas the mechanism underlying promotion in metastatic breast cells under ambient oxygen has not been well understood. Here, we demonstrated that aberrant expression signal-induced proliferation-associated 1 (SIPA1) enhanced and altered main source ATP production from oxidative phosphorylation to cells. We revealed SIPA1 promoted transcription EPAS1 , which known as gene encoding hypoxia-inducible factor-2α...