A5046551964- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Face Recognition and Perception
- Visual perception and processing mechanisms
- Nanoparticle-Based Drug Delivery
- Multisensory perception and integration
- Nanoplatforms for cancer theranostics
- Neuroscience and Music Perception
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Electron Spin Resonance Studies
- Acute Ischemic Stroke Management
- Educational Technology and Pedagogy
- Neurological Disease Mechanisms and Treatments
- Photoacoustic and Ultrasonic Imaging
- Tactile and Sensory Interactions
- Advanced NMR Techniques and Applications
- Action Observation and Synchronization
- Angiogenesis and VEGF in Cancer
- Aesthetic Perception and Analysis
- Intracerebral and Subarachnoid Hemorrhage Research
- Facial Nerve Paralysis Treatment and Research
- Biomedical and Engineering Education
- Photodynamic Therapy Research Studies
Binzhou University
2016-2025
Binzhou Medical University
2016-2025
Xian Central Hospital
2024
Guangdong Provincial People's Hospital
2023
Guangdong Academy of Medical Sciences
2023
Southern Medical University
2023
Guangxi University for Nationalities
2005
In this study, metalla-aromatic agents and a cluster of superparamagnetic iron oxide nanoparticles were loaded inside micellar carrier used for MRI/PA imaging-guided PTT/PDT synergistic cancer therapy.
Abstract Humans can easily recognize others' facial expressions. Among the brain substrates that enable this ability, considerable attention has been paid to face‐selective areas; in contrast, whether motion‐sensitive areas, which clearly exhibit sensitivity movements, are involved expression recognition remained unclear. The present functional magnetic resonance imaging (fMRI) study used multi‐voxel pattern analysis (MVPA) explore decoding both and areas. In a block design experiment,...
Glutamate dysregulation is one of the key pathogenic mechanisms major depressive disorder (MDD), and glutamate chemical exchange saturation transfer (GluCEST) has been used for measurement in some brain diseases but rarely depression.To investigate GluCEST changes hippocampus MDD relationship between hippocampal subregional volumes.Cross-sectional.Thirty-two patients (34% males; 22.03 ± 7.21 years) 47 healthy controls (HCs) (43% 22.00 3.28 years).3.0 T; magnetization prepared rapid gradient...
Abstract Vascular endothelial growth factor B (VEGF-B) was discovered a long time ago. However, its role in hyperglycemia- and VEGF-A inhibition-induced retinal apoptosis remains unknown thus far. Yet, drugs that can block VEGF-B are being used to treat patients with diabetic retinopathy other ocular neovascular diseases. It is therefore urgent have better understanding of the function these pathologies. Here, we report both streptozotocin (STZ)-induced diabetes rats Macugen intravitreal...
Background Abnormal levels of glutamate constitute a key pathophysiologic mechanism in epilepsy. The use chemical exchange saturation transfer (GluCEST) imaging to measure pediatric epilepsy is rarely reported research. Purpose To investigate hippocampal level variations and the correlation between subregional volumes. Study Type Cross‐sectional, prospective. Subjects A total 38 school‐aged patients with structurally normal MRI as determined by at least two independent radiologists (60%...
With the development of nanotechnology, a theranostics nanoplatform can have broad applications in multimodal image-guided combination treatment cancer precision medicine. To overcome limitations single diagnostic imaging mode and chemotherapeutic approach, we intend to combat tumor growth provide therapeutic interventions by integrating capabilities effective therapies on an advanced platform. So, constructed IO@MnO2@DOX (IMD) hybrid nanoparticles composed superparamagnetic iron oxide (IO),...
It is an important question how human beings achieve efficient recognition of others' facial expressions in cognitive neuroscience, and it has been identified that specific cortical regions show preferential activation to previous studies. However, the potential contributions connectivity patterns processing remained unclear. The present functional magnetic resonance imaging (fMRI) study explored whether could be decoded from (FC) using multivariate pattern analysis combined with machine...
Background Ketamine is a quick acting antidepressant drug, and an accurate detection method lacking. Ketamine's effects in rat depression model have not previously been well explored using glutamate chemical exchange saturation transfer (GluCEST). Purpose To investigate the GluCEST changes of chronic unpredictable mild stress (CUMS) rats after receiving either ketamine or saline injection. Study Type Randomized animal trial. Animal Model 12 CUMS 6 Sprague–Dawley rats. Divided into three...
Cerebral small vessel disease (CSVD) is a neurodegenerative with hidden symptoms and difficult to diagnose. The diagnosis mainly depends on clinical neuroimaging. Therefore, we explored the potential of combining detection MRI-based radiomics features for CSVD in large cohort. A total 118 patients 127 healthy controls underwent quantitative susceptibility mapping 3D-T1 scans, all completed multiple cognitive tests. Lasso regression was used select features, model constructed based...
Anti-VEGF-A therapy has proven to be effective for many neovascular diseases. However, drug resistance anti-VEGF-A treatment can develop. Also, not all patients with diseases are responsive treatment. The mechanisms underlying these important issues remain unclear. In this study, using different model systems, we found that inhibition of VEGF-A directly upregulated PDGF-CC and its receptors in multiple cell types pathological angiogenesis vitro vivo. Importantly, further revealed...
Background Adjusting abnormal glutamate neurotransmission is a crucial mechanism in the treatment of depression. However, few non‐invasive techniques could effectively detect changes neurotransmitters, and no consensus exists on whether affect resting‐state function Purpose To study chemical exchange saturation transfer (GluCEST) value hippocampus rat model exposed to chronic unpredictable mild stress (CUMS), explore effect this change activity hippocampal glutamatergic neurons. Study Type...
Our human brain can rapidly and effortlessly perceive a person's emotional state by integrating the isolated faces bodies into whole. Behavioral studies have suggested that encodes whole persons in holistic rather than part-based manner. Neuroimaging also shown body-selective areas prefer to sum of their parts. The played crucial role representing relationships between emotions expressed different However, it remains unclear which regions perception is represented combination bodies, what...
Imaging-guided cancer theranostic is a promising strategy for diagnostic and therapeutic. Photodynamic therapy (PDT), as an approved treatment modality, limited by the poor solubility dispersion of photosensitizers (PS) in biological fluids. Herein, it demonstrated that superparamagnetic iron oxide (SPIO)-based nanoparticles (SCFs), prepared conjugated with Chlorin e6 (Ce6) modified folic acid (FA) on surface, can be used versatile drug delivery vehicles effective PDT. The are great carriers...