Quantitative susceptibility mapping (QSM) can study the values of brain tissue which allows for noninvasive examination local iron levels in both normal and pathological conditions. Our compares deposition gray matter (GM) nuclei between cerebral small vessel disease (CSVD) patients healthy controls (HCs), exploring factors that affect cognitive function. A total 321 subjects were enrolled this study. All had including Stroop color word test (SCWT) MRI multiecho gradient echo (mGRE)...

Abstract We aimed to investigate alterations in functional brain networks and assess the relationship between impairment topological network changes cerebral small vessel disease (CSVD) patients with without microbleeds (CMBs). constructed individual whole‐brain, region of interest (ROI) level connectivity (FC) for 24 CSVD CMBs (CSVD‐c), 42 (CSVD‐n), 36 healthy controls (HCs). Then, we used graph theory analysis global nodal disruptions groups relate clinical parameters. found that both...

Neuroimaging studies have demonstrated extensive brain functional alterations in cognitive and motor areas Type 2 diabetes mellitus (T2DM) with diabetic peripheral neuropathy (DPN), suggesting potential large-scale networks related to DPN associated cognition dysfunction. In this study, using resting-state connectivity (FC) graph theory computational approaches, we investigated the topological disruptions of 28 DPN, 43 T2DM without (NDPN), 32 healthy controls (HCs) examined correlations...

This study explored the relationships between brain iron levels, emotion, and cognitive motor function in cerebral small vessel disease (CSVD) patients using quantitative susceptibility mapping (QSM). A total of 208 subjects were enrolled this study. QSM map was calculated from multiecho GRE data via morphology-enabled dipole inversion with an automatic uniform cerebrospinal fluid zero reference algorithm (MEDI+0). Multiple linear regression analysis applied to explore clinical factors...

Abstract Aims Emerging evidence suggests that cerebral small vessel disease (CSVD) pathology changes brain structural connectivity (SC) and functional (FC) networks. Although network‐level SC FC are closely coupled in the healthy population, how SC‐FC coupling correlates with neurocognitive outcomes patients different CSVD burdens remains largely unknown. Methods Using multimodal MRI, we reconstructed whole‐brain networks for 54 severe burden (CSVD‐s), 106 mild (CSVD‐m), 79 controls. We then...

Emerging evidence highlights cerebral microbleeds (CMBs) as hallmarks of small vessel disease (CSVD) underlying depression and cognitive dysfunction. This study aimed to reveal how cognition-related white matter (WM) abnormalities are topologically presented, the network-level structural disruptions associated with CMBs in CSVD. We used probabilistic diffusion tractography graph theory investigate brain WM network topology CSVD patients (n = 64, CSVD-c) without 138, CSVD-n) 90 healthy...

The effects of preeclampsia superimposed on chronic hypertension (CHTN-PE) the structure and function human brain are mostly unknown. purpose this study was to examine altered gray matter volume (GMV) its correlation with cognitive in pregnant healthy women, non-pregnant individuals, CHTN-PE patients.Twenty-five patients, thirty-five controls (PHC) (NPHC) were included underwent assessment testing. A voxel-based morphometry (VBM) approach applied investigate variations GMV among three...

Abstract To reveal the network-level structural disruptions associated with cognitive dysfunctions in different cerebral small vessel disease (CSVD) burdens, we used probabilistic diffusion tractography and graph theory to investigate brain network topology 67 patients a severe CSVD burden (CSVD-s), 133 mild (CSVD-m) 89 healthy controls. We one-way analysis of covariance assess altered topological measures between groups, then evaluated their Pearson correlation parameters. Both control...

This study aims to investigate the disrupted topological organization of gray matter (GM) structural networks in cerebral small vessel disease (CSVD) patients with microbleeds (CMBs). Subject-wise were constructed from GM volumetric features 49 CSVD CMBs (CSVD-c), 121 without (CSVD-n), and 74 healthy controls. The used graph theory analyze global regional properties network their correlation cognitive performance. We found that both control groups exhibited efficient small-world networks....

Diffusion tensor imaging (DTI) is recommended as a sensitive method to explore white matter (WM) microstructural alterations. Cerebral small vessel disease (CSVD) may be accompanied by extensive WM deterioration, while cerebral microbleeds (CMBs) are an important factor affecting CSVD. Fractional anisotropy (FA), mean diffusivity (MD), axial (AD) and radial (RD) images from 49 CSVD patients with CMBs (CSVD-c), 114 without (CSVD-n), 83 controls were analyzed using DTI-derived tract-based...

Cerebral small vessel disease (CSVD) is a neurodegenerative with hidden symptoms and difficult to diagnose. The diagnosis mainly depends on clinical neuroimaging. Therefore, we explored the potential of combining detection MRI-based radiomics features for CSVD in large cohort. A total 118 patients 127 healthy controls underwent quantitative susceptibility mapping 3D-T1 scans, all completed multiple cognitive tests. Lasso regression was used select features, model constructed based...

Cerebral small vessel disease (CSVD) is a universal neurological disorder in older adults that occurs connection with cognitive dysfunction and chief risk factor for dementia stroke. While whole-brain voxelwise structural functional abnormalities CSVD have been heavily explored, the degree of structure-function coupling abnormality possible patients different burdens remains largely unknown. This study included 53 severe burden (CSVD-s), 108 mild (CSVD-m) 76 healthy controls. A metric low...

We used probabilistic diffusion tractography and graph theory based on DTI to investigate the topologic organization of white matter (WM) structural networks in 54 patients with severe CSVD burden (CSVD-s), 117 mild (CSVD-m) 73 healthy controls. Compared CSVD-m controls, CSVD-s exhibited significantly increased local efficiency, normalized clustering coefficient small world index, partially reorganized hub distributions. In addition, showed nodal efficiency some brain regions. Intriguingly,...

<title>Abstract</title> <bold>Background: </bold>Quantitative susceptibility mapping (QSM) can study the values of brain tissue which allows for noninvasive examination local iron levels in both normal and pathological conditions. <bold>Purpose:</bold> Our compares deposition gray matter (GM) nuclei between cerebral small vessel disease (CSVD) patients healthy controls (HCs), exploring factors that affect cognitive function. <bold>Materials Methods:</bold> A total 321 subjects were enrolled...

Motivation: The factors that influence iron deposition in the normal-appearing white matter (NAWM) of brain have yet to be thoroughly examined. Goal(s): This study aimed measure levels a community population and identify affecting NAWM levels. Approach: Brain load was assessed using quantitative susceptibility mapping. Results: Age, hypertension, T2DM, smoking, BMI, APOE4 affect metabolism certain regions. Moreover, mean values corpus callosum are significantly related some cognitive tests....

Motivation: Brain iron deposition and analysis of risk factors in cerebral small vessel disease patients with different total (CSVD) scoresGoal(s): Our study compares brain gray matter (GM) nuclei between CSVD healthy controls (HCs), exploring that affect cognitive function. Approach: load was assessed using quantitative susceptibility mapping. Results: Age, diabetes, smoking may increase the basal ganglia, associated decline. The mean values neostriatum played a mediating role association...

Motivation: The impact of different cerebral small vessel disease (CSVD) burden on brain structural and functional connectivity coupling their correlation with neurocognitive outcomes remain largely unknown. Goal(s): To explore the alterations connection network (SC-FC) in whole modules patients CSVD compared healthy controls. Approach: Diffusion tensor imaging (DTI) Resting-state blood-oxygen-level-dependent (BOLD) fMRI techniques were used to analyze connections. Results: Severe exhibited...

Motivation: Diabetes is thought to be related an imbalance in iron homeostasis and abnormal accumulation. Goal(s): To explore the changing mode of brain metabolism basal ganglia type 2 diabetes (T2DM) patients with diabetic peripheral neuropathy (DPN) without DPN (NDPN) using quantitative susceptibility mapping (QSM). Approach: Brain T2DM was assessed QSM. Results: Susceptibilities putamen caudate nucleus were higher than healthy controls, while there no significant difference between NDPN...

Motivation: The deposition of excess iron in subcortical nuclei may be linked to the burden cerebral small vessel disease (CSVD) and could contribute decreased cognitive performance. Goal(s): To investigate relationship between CSVD severity, as well impairment. Approach: Brain was assessed by quantitative susceptibility mapping (QSM). Results: Susceptibility posterior part right hippocampus (pHIP-R) negatively correlated with performance positively severity. Impact: Iron pHIP-R an early...

<title>Abstract</title> Objective To reveal the network-level structural disruptions associated with cognitive dysfunctions in different cerebral small vessel disease (CSVD) burdens. Materials and Methods Probabilistic diffusion tractography graph theory were used to investigate brain network topology 67 patients a severe CSVD burden (CSVD-s), 133 mild (CSVD-m) 89 healthy controls. We one-way analysis of covariance assess altered topological measures between groups, then evaluated their...