A5100345961- Ginger and Zingiberaceae research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cardiac Ischemia and Reperfusion
- Cytokine Signaling Pathways and Interactions
- Helicobacter pylori-related gastroenterology studies
- Cardiac Fibrosis and Remodeling
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Endometriosis Research and Treatment
- Cancer, Lipids, and Metabolism
- Bone Metabolism and Diseases
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Extracellular vesicles in disease
- Apelin-related biomedical research
- Gut microbiota and health
- Biomarkers in Disease Mechanisms
- Cardiac electrophysiology and arrhythmias
- Reproductive System and Pregnancy
- Lipid metabolism and biosynthesis
- Viral Infections and Immunology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
Hebei University of Chinese Medicine
2016-2023
Yangzhou University
2016
National Natural Science Foundation of China
2016
To investigate the protection of cinnamic aldehyde (CA) against myocardial ischemia/hypoxia (I/H) injury and its potential mechanisms in vivo vitro. Mice were pretreated with CA for 7 days, then isoproterenol (85 mg/kg) was administered 2 consecutive days to assess cardioprotection. Furthermore, an vitro I/H model established by administering CoCl2 (600 μM) H9c2 cells 24 h. 12 h protection. We observed that improved electrocardiogram histopathological changes decreased creatine kinase...
Transforming growth factor-β1 (TGF-β1) is a potent stimulator of the epithelial-to-mesenchymal transition (EMT), which key event in initiation tumor cell metastasis. Aspirin-triggered resolvin D1 (AT-RvD1) known to be involved resolution inflammation; however, whether AT-RvD1 exerts effects on TGF-β1-induced EMT remains unclear. Thus, we first explored lung cancer cells. Treatment with TGF-β1 increased level reactive oxygen species (ROS) and reduced expression nuclear factor...
Hua-Zhuo-Jie-Du (HZJD), a Chinese herbal prescription consisting of 11 herbs, is commonly used in China to treat chronic atrophic gastritis (CAG). We aimed determine the effect HZJD on microbiome-associated metabolic changes CAG rats.The rat models were induced by 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) combined with irregular fasting and 2% sodium salicylate, which was intragastrically administrated fasted animals for 24 weeks. The rats medicine (CM) group administered daily dose 14.81...
10-Gingerol (10-Gin), an active ingredient extracted from ginger, has been reported to have beneficial effects on the cardiovascular system. However, its protective myocardial ischemia (MI) and underlying cellular mechanisms are still unclear. To investigate protection conferred by 10-Gin against MI injury potential in cardiomyocytes via patch-clamp molecular biology techniques. A rat model was established using subcutaneous injection of isoproterenol (85 mg/kg) administered two consecutive...
Objectives Alantolactone (AL) is a compound extracted from the roots of Inula Racemosa that has shown beneficial effects in cardiovascular disease. However, cardioprotective mechanism AL against hypoxic/ischemic (H/I) injury still unclear. This research aimed to determine AL’s ability protect heart isoproterenol (ISO)-induced MI vivo and cobalt chloride (CoCl 2 ) induced H/I vitro. Methods Electrocardiography (ECG), lactate dehydrogenase (LDH), creatine kinase (CK), cardiac troponin I (cTnI)...
Abstract Myocardial ischemia (MI) remains the leading cause of mortality worldwide. Therefore, it is urgent to seek treatment protect heart. [8]‐Gingerol (8‐Gin), one most active ingredients in ginger, has antioxidant, cardiotonic, and cardiovascular protective properties. The present study elucidated cardioprotection effects underlying mechanisms 8‐Gin isoproterenol (ISO)‐induced MI. ISO (85 mg/kg/d) was subcutaneously injected for 2 consecutive days induce acute MI model rats....
Atherosclerotic plaque rupture is an important pathophysiologic mechanism of acute coronary syndrome. Emerging microRNAs (miRNAs) have been implicated in the atherosclerotic formation and macrophage autophagy during development atherosclerosis (AS). Hence, this study was conducted to explore role microRNA-135b (miR-135b) macrophages mouse models AS. The expression miR-135b erythropoietin receptor (EPOR) altered mice clarify their effect on inflammation, cell activities aortic tissues,...
Aim: Alzheimer's disease (AD) is the most frequent cause of dementia and characterized by accumulation β-amyloid peptides in plaques vessel walls. This study proposed a hypothesis an inhibitory role miR-96-5p AD via regulating Foxo1. Methods & methods: mouse models were established injecting with 1% pentobarbital. Results: Knockdown presence naringin was shown to reduce expression Foxo1 contents superoxide dismutase, catalase glutathione peroxidase, yet increase lipocalin-2 as well...
Purpose: Roscovitine (Rosc) is a selective inhibitor of cyclin-dependent kinases (CDKs) and promising therapy for various cancers. However, limited information available on the biological significance Rosc in vascular smooth muscle cells (VSMCs), cell type critical development proliferative diseases. In this study, we address effects regulating VSMC proliferation, both vitro vivo, exploring underlying molecular mechanisms. Methods: The proliferations cell-cycle distributions cultured VSMCs,...
Abstract Background: This study will systematically synthesize the evidence on potential association between gastroesophageal reflux disease (GERD) and depression disorder (DD). Methods: We search following electronic bibliographic databases: PubMed/MEDLINE, Embase, Cochrane Library, Web of Science, Chinese Bio Medical Literature Database, China National Knowledge Infrastructure (CNKI), Science Technology Journal database (VIP) Wanfang Data. In addition, ongoing trials be retrieved from WHO...
Abstract Objectives Gingerols are bioactive compounds derived from ginger, our experiment investigates the effects of 6-, 8- and 10-Gin on human ether-à-go-go-related gene (hERG) K+ channels by using patch clamp technology. Key findings hERG currents were suppressed in a concentration-dependent manner. The IC50 values 41.5, 16.1 86.5 μM for currents, respectively. maximum inhibitory caused 44.3% ± 2.0%, 88.6% 1.3% 63.1% 1.1%, respectively, almost completely reversible. Conclusion These...
Abstract Objective: This study aimed to evaluate the protective effect and underlying mechanisms of daisy leaf gentian, also known as bellidifolin (BEL), against heart injury in mice. Methods: Mice were randomly divided into four groups: Control, ADM (ADM alone), ADM+BEL plus gentian ketone monomer), ADM+CAP captopril). We sacrificed mice using cervical dislocation.Heart structure function evaluated echocardiography hemodynamic testing. The serum levels creatine kinase,aspartate...
Objective To explore the mechanism of phlegm-resolving and stasis- removing herbals on NAFLD by observing expressions PGC1α mRNA insulin resistance. Methods A total 60 male SD rats were randomly divided into normal group, model positive medication control high-dose, middle-dose low-dose group. The fed with high-fat forage for 8 weeks. group gavaged Dongbao-Gantai liquid (0.9 g/kg/day), Xiaotan-Huayu (43.34、32.50、21.67 equal volume distilled water. drugs given 1 ml/100 g last levels...