A5070606285- Ginger and Zingiberaceae research
- Retinoids in leukemia and cellular processes
- Ion channel regulation and function
- Immune cells in cancer
- Genomics, phytochemicals, and oxidative stress
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Arsenic contamination and mitigation
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
- Saffron Plant Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac electrophysiology and arrhythmias
- Vitamin C and Antioxidants Research
- Inflammasome and immune disorders
- Pharmacological Effects of Natural Compounds
- Circular RNAs in diseases
- Microbial Metabolism and Applications
- Caveolin-1 and cellular processes
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Nuclear Receptors and Signaling
- Heat shock proteins research
- Mangiferin and Mango Extracts
- Ion Channels and Receptors
Hebei University of Chinese Medicine
2017-2025
Hebei Science and Technology Department
2025
Hesperetin (HSP) is a natural flavonoid that offers useful curative effects for cardiovascular diseases, but its effect on myocardial ischemia and precise mechanism remains unclear. The aim of this study to explore the potential cardioprotective HSP caused by isoproterenol (ISO). Adult male Kunming mice were randomly divided into five groups: control, ISO, low-dose (L-HSP, 25 mg/kg/d), high-dose (H-HSP, 50 verapamil (VER) group. Treatment groups received or VER seven days, other than control...
Tannic acid (TA), a group of polyphenolic compounds, has multiple anticancer, antimutagenic, antioxidant and anti-inflammatory activities. However, the effects TA on arsenic trioxide (ATO)-induced nephrotoxicity are still relatively unknown. This study investigated protective potential mechanisms ATO-induced in rats. Rats were intragastrically administered with concurrent ATO infused intraperitoneally over 10 days. Renal morphology changes observed through light microscopy. The levels...
Liquiritigenin (LQ) has protective effects against various hepatotoxicities. However, its specific role on arsenic trioxide (ATO)-induced hepatotoxicity and the related biomolecular mechanisms remain unclear. The purpose of this study is to explore actions LQ ATO-induced in mice. was administered orally at 20 40 mg/kg per day for seven consecutive days with an intraperitoneal injection ATO (5 mg/kg). Liver injury induced by alleviated treatment as reflected reduced histopathological damage...
Background and Purpose Natural flavonoids are ubiquitous in dietary plants vegetables have been proposed to antiviral, antioxidant, cardiovascular protective anticancer effects. Transmembrane member 16A (TMEM16A)‐encoded Ca 2+ ‐activated Cl − channels play a variety of physiological roles many organs tissues. Overexpression TMEM16A is also believed be associated with cancer progression. Therefore, inhibition current may potential target for therapy. In this study, we screened broad spectrum...
Objective: This study aimed to investigate the therapeutic effect of Yueju Pill (YJP) on functional dyspepsia (FD) rats and its mechanism promoting gastrointestinal motility. Methods: We replicated FD rat models using classical tail pinching irregular feeding for 14 days. After 28 days YJP treatment, we measured gastric emptying rate intestinal propulsion rats. Hematoxylin-eosin (H&E) staining was used observe pathological damage in antrum. The serum levels related brain-gut peptides...
8-gingerol (8-Gin) is the series of phenolic substance that extracted from ginger. Although many studies have revealed 8-Gin has multiple pharmacological properties, possible underlying mechanisms against myocardial fibrosis (MF) remains unclear. The study examined exact role and potential isoproterenol (ISO)-induced MF. Male mice were intraperitoneally injected with (10 20 mg/kg/d) concurrently subcutaneously ISO for 2 weeks. Electrocardiography, pathological heart morphology, enzymes,...
Purpose: Despite significant advances in interventional treatment, myocardial infarction (MI) and subsequent cardiac fibrosis remain major causes of high mortality worldwide. Liquiritin (LQ) is a flavonoid extract from licorice that possesses variety pharmacological properties. However, to our knowledge, the effects LQ on after MI have not been reported detail. The aim research was explore potential role mechanism MI-induced damage. Methods: models were established by ligating left anterior...
Xianglianhuazhuo formula (XLHZ) has a potential therapeutic effect on chronic atrophic gastritis (CAG). However, the specific molecular mechanism remains unclear.
Arsenic trioxide (ATO) is a frontline chemotherapy drug used in the therapy of acute promyelocytic leukemia. However, clinical use ATO hindered by its cardiotoxicity. The present study aimed to observe potential effects and underlying mechanisms tannic acid (TA) against ATO‑induced Male rats were intraperitoneally injected with (5 mg/kg/day) induce TA (20 40 was administered evaluate cardioprotective efficacy heart injury rats. Administration resulted pathological damage increased oxidative...
Safranal (SFR) is the major constituent of saffron. The purpose this study was to observe effect SFR on myocardial ischemia induced by isoprenaline (ISO) and explore its possible mechanism. rat model established subcutaneous injection ISO (85 mg/kg/d) 8th 9th day experiment. Serum creatine kinase (CK), lactate dehydrogenase (LDH), malondialdehyde (MDA) superoxide dismutase (SOD) were measured, as changes in calcium concentration, reactive oxygen species (ROS) cardiac morphology tissue....
Ferulic acid (FA) is a natural polyphenol compound existing in many plants. The purpose of this study was to investigate the effect FA on non-alcoholic steatohepatitis (NASH) induced by high-cholesterol and high-fat diet (HCHF) its possible mechanism. Rats were fed HCHF for 12 weeks establish NASH model. improved liver coefficients had no body weight changes. could reduce serum alanine transferase (ALT) aspartate (AST) activities. attenuated increase total cholesterol (TC), triglyceride (TG)...
6-Gingerol (6G) is the main phenolic active component of ginger, which has a certain protective effect against liver injury induced by drugs, and chemical pollutants. However, mechanism protection 6G arsenic trioxide (ATO)-induced remains unclear. The network pharmacology animal experiment results respectively indicated that oxidative stress inflammatory responses were closely related to ATO-induced injury. can alleviate stress. Furthermore, attenuate release pro-inflammatory factors ATO...
Abstract Myocardial ischemia (MI) remains the leading cause of mortality worldwide. Therefore, it is urgent to seek treatment protect heart. [8]‐Gingerol (8‐Gin), one most active ingredients in ginger, has antioxidant, cardiotonic, and cardiovascular protective properties. The present study elucidated cardioprotection effects underlying mechanisms 8‐Gin isoproterenol (ISO)‐induced MI. ISO (85 mg/kg/d) was subcutaneously injected for 2 consecutive days induce acute MI model rats....
Background and Objective: Arsenic trioxide (As2O3) induced cardiotoxicity to limit the clinical applications of effective anticancer agent. 6-Gingerol (6G) is main active ingredient ginger, a food with many health benefits. The present study aims investigate potential pharmacological mechanisms 6G on As2O3-induced myocardial injury. Methods Results: Fifty KunMing mice were divided into five groups (n = 10) receiving: 1) physiological saline; 2) (20 mg/kg) alone; 3) As2O3 (5 mg/kg); 4) (10 5)...
Liquiritin (LIQ) is a flavonoid known for its cardioprotective properties, extracted from <em>Glycyrrhiza</em> <em>uralensis</em> Fisch. The purpose of the present study was to investigate protective mechanism LIQ against hypoxia/reoxygenation (H/R) injury through <em>in</em> <em>vitro</em> experiments, with goal enhancing pharmacological effects. Initially, network pharmacology employed explore targets and mechanisms LIQ. Subsequently, an H/R model established using H9c2 cells. Potential...
Ischemia/hypoxia (I/H)-induced myocardial injury has a large burden worldwide. Hesperetin (HSP) cardioprotective effect, but the molecular mechanism underlying this is not clearly established. Here, we focused on protective mechanisms of HSP against I/H-induced myocardium injury. H9c2 cardiomyocytes were challenged with CoCl2 for 22 h to imitate hypoxia after treatment groups received 4 h. The viability was evaluated, and cardiac function indices, reactive oxygen species, apoptosis,...
Previous studies have found that Salvia miltiorrhiza (SM) injection a protective effect on the iron overloaded (IO) heart. However, mechanisms are not completely known. In present study, we investigated underlying based transport-related proteins. The rats were randomly divided into five groups: control, IO group, low-dose SM high-dose and deferoxamine control group. Iron dextran was injected to establish model. After 14 days of treatment, cardiac histological changes observed by hematoxylin...