A5048211525- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Click Chemistry and Applications
- Helicobacter pylori-related gastroenterology studies
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Pancreatic and Hepatic Oncology Research
- Glycosylation and Glycoproteins Research
- Endometrial and Cervical Cancer Treatments
- Diabetes and associated disorders
- HVDC Systems and Fault Protection
- Transgenic Plants and Applications
- Infant Nutrition and Health
- Seaweed-derived Bioactive Compounds
- Viral Infections and Vectors
- Gut microbiota and health
- Toxin Mechanisms and Immunotoxins
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Diabetes Management and Research
- Diet and metabolism studies
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Sichuan University
2020-2024
West China Hospital of Sichuan University
2024
Nanjing University
2024
Nanjing Medical University
2024
Augusta University
2023
Binzhou Medical University
2013
Augusta University Health
2012
The incidence of intestinal diseases increases with age, yet the mechanisms governing gut aging and its link to diseases, such as colorectal cancer (CRC), remain elusive. In this study, while considering sex proximal-distal variations, we used a multi-omics approach in non-human primates (Macaca fascicularis) shed light on heterogeneity identify potential regulators aging. We explored roles several regulators, including those from tryptophan metabolism, function lifespan Caenorhabditis...
Abstract Intestinal tuft cells, a kind of epithelial immune rapidly expand in response to pathogenic infections, which is associated with infection‐induced interleukin 25 (IL‐25) upregulation. However, the metabolic mechanism IL‐25‐induced cell expansion largely unknown. Folate metabolism provides essential purine and methyl substrates for proliferation differentiation. Thus, we aim investigate roles folate playing by enteroviral infection recombinant murine IL‐25 (rmIL‐25)...
BACKGROUND Pancreatic cancer is one of the most lethal malignancies, characterized by poor prognosis and low survival rates. Traditional prognostic factors for pancreatic offer inadequate predictive accuracy, often failing to capture complexity disease. The hypoxic tumor microenvironment has been recognized as a significant factor influencing progression resistance treatment. This study aims develop model based on key hypoxia-related molecules enhance prediction accuracy patient outcomes...
Parkinson's disease (PD) is one of the neurodegenerative diseases that characterized by obvious motor and some nonmotor symptoms. Various therapeutics failed in effective treatment PD because impaired neurological function brain various complications. Periplaneta Americana oligosaccharides (OPA), main active ingredients extracted from medicine residues (P. Americana), have been reported to exert anti-inflammatory effects. The purpose this study was evaluate possible mechanisms OPA against...
Plant lectins are carbohydrate-binding proteins with nonimmune origin, which can reversibly bind carbohydrates, agglutinate cells, and precipitate polysaccharides glycoconjugates. have attracted much attention for their anti-virus, anti-proliferation, pro-apoptosis properties. Thus the exploration of new has received special attention. Here we purified a mannose-binding lectin from rhizomes Liparis nervosa by ion exchange chromatography on DEAE-Sepharose, affinity Mannose-Sepharose 4B, gel...
While astrocyte-to-neuron (AtN) reprogramming holds great promise in regenerative medicine, the molecular mechanisms that govern this unique biological process remain elusive. To understand function of miRNAs during AtN process, we performed RNA-seq both mRNAs and on human astrocyte (HA) cultures upon NeuroD1 overexpression. Bioinformatics analyses showed not only activated essential neuronal genes to initiate but also induced miRNA changes HA. Among upregulated miRNAs, identified miR-375...
ABSTRACT While astrocyte-to-neuron (AtN) reprogramming holds great promise in regenerative medicine, the molecular mechanisms that govern this unique biological process remain elusive. MicroRNAs (miRNAs), as post-transcriptional regulators of gene expression, play crucial roles during development and under various pathological conditions. To understand function miRNAs AtN process, we performed RNA-seq both mRNAs on human astrocyte (HA) cultures upon NeuroD1 overexpression. Bioinformatics...
Histone methylation/demethylation facilitate to maintain balanced histone methylation levels and underpin gene regulation, playing the key roles in epigenetic regulation. Suppressor of variegation 4-20 homolog 1 (SUV420H1), a member class Lysine Methyltransferase enzyme regulation pathways controlling metabolism tumorigenesis, is crucial cell homeostasis. The inhibition SUV420H1 has emerged as promising candidate for drug development cancer therapy. Herein, two potential potent inhibitors...
To investigate the relationships of leukemia inhibitory factor receptor (LIFR) with cervical cancer invasion and metastasis.From January 2021 to December 2022, 45 patients treated for lung metastases were identified. Western blotting was used determine expression Hippo-YAP signaling pathway-related proteins. Meanwhile, 40 healthy Sprague-Dawley nude mice evenly randomized into two groups, which injected LIFR-overexpressing (study group) or normal cells (control group). The tissue removed...
Objective To explore the clinicopathology characteristics of endometrial adenocarcinoma and non-endometrial adenocarcinoma.Methods The clinical data 306 patients with endometrioid cancer were analyzed retrospectively.Results accounted for 90％ all patients,and 10％.Compared adenocarcinoma,the average age was older[(59.32 ± 7.77)years],the constitution ratio postmenopausal higher(90％),the clinicopathologic stage later(P =0.000),the grade histology higher(P myometrial invasion deeper(P...
Early drug discovery for cancer treatment was based on targeting known proliferation mechanisms and the disruption of essential cellular functions. These therapies, although specific, were shown to have a wide range toxicities. In contrast, therapies targeted non functions less toxic effective. Currently, phase has shifted identify without specific molecular targets in mind. This approach allows identification compounds against multiple or pathway molecules. Furthermore, that are efficacious...