A5057661877- Bone and Dental Protein Studies
- dental development and anomalies
- RNA modifications and cancer
- Cancer-related gene regulation
- Toxin Mechanisms and Immunotoxins
- Cancer-related molecular mechanisms research
- Oral Health Pathology and Treatment
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Spine and Intervertebral Disc Pathology
- Oral and Maxillofacial Pathology
- Glycosylation and Glycoproteins Research
- Oral and gingival health research
- Dendrimers and Hyperbranched Polymers
- Nanoparticle-Based Drug Delivery
- Proteoglycans and glycosaminoglycans research
- Periodontal Regeneration and Treatments
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Parathyroid Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Cervical and Thoracic Myelopathy
- Spinal Hematomas and Complications
Harbin Medical University
2014-2025
First Affiliated Hospital of Harbin Medical University
2019-2025
Texas A&M University
2019
Autophagy inhibition is emerging as a new paradigm for efficient cancer therapy by overcoming multidrug resistance (MDR). Here, we developed an effective chemotherapeutic system oral squamous cell carcinoma (OSCC) based on polymeric nanomicelles codelivery of the anticancer drug doxorubicin (DOX) and autophagy inhibitor LY294002 (LY). The hydrophobic DOX was conjugated onto hydrophilic pH-responsive hyperbranched polyacylhydrazone (HPAH), forming DOX-conjugated HPAH (HPAH-DOX). Due to its...
Interleukin-24(IL-24), also referred to as melanoma differentiation-associated gene-7(mda-7), is a unique member of the IL-10 gene family, which displays nearly ubiquitous cancer-specific toxicity. The most notable feature IL-24 selectively induced growth suppression and apoptosis in various cancer cells, with no harmful effects toward normal cells. Autophagy self-protective mechanism many kinds tumor cells that respond anticancer treatment. It reported autophagy inhibition could enhance...
ABSTRACT Background Although triptolide has demonstrated efficacy in treating oral squamous cell carcinoma (OSCC), its precise molecular mechanism remains unclear. This study investigated the underlying triptolide's action lncRNA‐mediated competing endogenous RNA (ceRNA) regulation. Methods The impact of on OSCC vivo was validated using a xenograft tumor model. Whole‐transcriptome sequencing and bioinformatics analysis were conducted to construct lncRNA‐miRNA‐mRNA regulatory network....
Amelogenesis imperfecta (AI) is a type of hereditary diseases that manifest defects in the formation or mineralization enamel. Recently, it reported inactivation FAM20C, well-known Golgi casein kinase, caused AI. However, mechanism still unknown. The aim this study was to explore molecular AI, which by ablation FAM20C.In Sox2-Cre;Fam20Cfl/fl (cKO) mouse, we found abnormal differentiation ameloblasts, improper and enamel, downregulation both mRNA protein level enamel matrix proteins,...
The current study was aimed to investigate the association of nudix hydrolase 1 (NUDT1) levels with prognosis oral squamous cell carcinoma (OSCC) patients.Western immunoblotting and qRT-PCR were used detect protein mRNA NUDT1 in 31 cases OSCC normal tissues. paraffin-embedded 62 18 tissues collected, pathological alterations assessed by immunohistochemistry. all patients followed up. Kaplan-Meier method analyze survival rate, Cox regression for multivariate analysis.Both gene statistically...
This investigation examined the effects of microRNA miR-34c-5p on proliferation, migration, and invasion oral squamous cell carcinoma (OSCC) mechanisms involved.The Gene Expression Omnibus (GEO) database was used to filter chips, GEO2R software (https://www.ncbi.nlm.nih.gov/geo/geo2r/) analyze microarray data (GSE28100 GSE45238). set enrichment analysis (GSEA) study relationship between expression distant metastasis pathological grade OSCC. The correlation TRIM29 (tripartite motif containing...
This study focused on investigating relation between biglycan (BGN) and decorin (DCN) expression prognostic outcome for oral squamous cell carcinoma (OSCC) cases.BGN DCN mRNA protein was detected by qRT-PCR Western-blotting (WB) assays from 31 OSCC samples as well healthy samples. work harvested 101 paraffin-embedded together with 30 samples, conducted immunohistochemical (IHC) staining assessing pathological changes. Association of BGN within explored Spearman's analysis. Survival rate...
Abstract Family with sequence similarity 20‐member C (FAM20C) is a kinase specific to most of the secreted phosphoproteome. FAM20C has been identified as causative gene Raine syndrome, initially characterized by lethal osteosclerosis bone dysplasia. However, since identification cases nonlethal syndrome hypophosphatemia rickets, previous definition become debatable and raised question about role mutations in controversial skeletal manifestation two forms disease. In this study, we aimed...