A5039398431- Vagus Nerve Stimulation Research
- Acupuncture Treatment Research Studies
- Anesthesia and Sedative Agents
- Neurogenesis and neuroplasticity mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Rate Variability and Autonomic Control
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Spinal Dysraphism and Malformations
- Airway Management and Intubation Techniques
- Neonatal and fetal brain pathology
- Respiratory Support and Mechanisms
- Epilepsy research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Pain Management
- Cerebrospinal fluid and hydrocephalus
- Enhanced Recovery After Surgery
- Cardiac Ischemia and Reperfusion
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroscience of respiration and sleep
- Congenital gastrointestinal and neural anomalies
- Music Therapy and Health
- Cancer, Stress, Anesthesia, and Immune Response
- Body Contouring and Surgery
- Advanced Glycation End Products research
Shuguang Hospital
2015-2025
Shanghai University of Traditional Chinese Medicine
2016-2025
Center for Clinical Research (United States)
2024
University of California, San Francisco
2024
University of Hong Kong
2024
University of South China
2023
Shanghai University
2020
Shanghai Jiao Tong University
2009-2015
Renji Hospital
2015
Second Military Medical University
2005-2012
Background Recent advances have indicated a complex interplay between the autonomic nervous system and innate immune system. Targeting neural networks for treatment of sepsis is being developed as therapeutic strategy. Because electroacupuncture at select acupoints can modulate activities system, we tested hypothesis that specific could systemic inflammatory responses improve survival via its impact on in rat model sepsis. Methods Sprague-Dawley male rats received 45 min before 1, 2, or 4 h...
Abstract Lack of liver regenerative capacity is the primary cause hepatic failure and even mortality in patients undergoing hepatectomy, with no effective intervention strategies currently available. Therefore, identifying efficacious interventions to enhance regeneration pivotal for optimizing clinical outcomes. Recent studies have demonstrated that vagotomy exerts an inhibitory effect on following partial thereby substantiating role played by vagus nerve process regeneration. In recent...
The emergence of myelinating oligodendrocytes represents a pivotal developmental milestone in vertebrates, given their capacity to ensheath axons and facilitate the swift conduction action potentials. It is widely accepted that cortical oligodendrocyte progenitor cells (OPCs) arise from medial ganglionic eminence (MGE), lateral/caudal (LGE/CGE), radial glial (RGCs). Here, we used two different fate mapping strategies challenge established notion LGE generates OPCs. Furthermore,...
Elderly frailty patients are at particular risk of sedation-related adverse events (SRAEs) during sedation. This study aimed to assess whether intravenous lidocaine could reduce the incidence SRAEs in elderly undergoing endoscopic retrograde cholangiopancreatography (ERCP). A total 210 scheduled for ERCP were randomly divided into two groups: and control. Patients group received (1.0 mg/kg) before anesthesia induction, followed by continuous infusion (2.0 mg/kg/h) ERCP. The control an equal...
Abstract Excessive release of high mobility group box-1 (HMGB1) protein from ischemic cardiomyocytes activates inflammatory cascades and enhances myocardial injury after reperfusion. Here we report evidence that electroacupuncture mice at Neiguan acupoints can inhibit the up-regulation cardiac HMGB1 following ischemia attenuate associated responses during These benefits were partially reversed by administering recombinant to further potentiated anti-HMGB1 antibody. Electroacupuncture-induced...
The study examined the global metabolic and some biochemical changes in rats with cholestasis induced by bile duct ligation (BDL). Serum samples were collected male Wistar BDL (n = 8) sham surgery at day 3 after for metabolomics analysis using a combination of reversed phase chromatography hydrophilic interaction (HILIC) quadrupole-time-of-flight mass spectrometry (Q-TOF MS). serum levels malondialdehyde (MDA), total antioxidative capacity (T-AOC), glutathione (GSH) disulfide (GSSG),...
In Brief BACKGROUND: Electroacupuncture (EA) is widely applied for pain management, but the analgesic effects of EA have not been fully elucidated. this study, we investigated effect on inflammatory caused by intraplantar injection complete Freund's adjuvant (CFA) and apelin/APJ expression in spinal cord rats. METHODS: The study was conducted 3 parts. part 1, Sprague-Dawley rats were divided into 4 groups (n = 10): sham, CFA, (CFA + 2 Hz at acupoints), NA-EA acupuncture without electrical...
Obstructive jaundice is associated with enhanced susceptibility to hypotensive shock, renal failure, and toxic effects of endotoxin, which results in high perioperative morbidity mortality. Since the normal arterial baroreflex function necessary for hemodynamic homeostasis improving survival sepsis, this study aimed determine whether sensitivity was impaired jaundiced patients.Thirty-five patients obstructive scheduled surgery were included, 30 nonjaundiced served as controls. A modified...
Some studies suggest that behavioral complications of cholestasis, such as fatigue and pruritus, may be associated with altered neurotransmission in the brain. Because inhaled anesthetics primarily act on ion channels receptors neuronal cell membrane alter synaptic transmission central nervous system, it is possible sensitivity to occur cholestatic patients. Therefore, authors compared minimum alveolar concentration (MAC)-awake desflurane obstructive jaundiced patients MACawake nonjaundiced...
Patients with obstructive jaundice have increased sensitivity to inhaled anesthetics. In rodent brain, bilirubin can enhance γ-aminobutyric acid A/glycinergic synaptic transmission. Etomidate is a nonbarbiturate hypnotic that induces sedation through A receptors in the central nervous system. We tested hypothesis patients an altered etomidate.The study design was comparison of etomidate requirements reach Bispectral Index 50 versus chronic cholelithiasis and normal levels. infused at 30...
Early growth response- (Egr-) 1 is an upstream master switch in controlling inflammatory responses following myocardial ischemia-reperfusion (I/R). Activation of extracellular signal-regulated protein kinase-1 and kinase-2 (ERK1/2) signaling known to upregulate Egr-1. ERK1/2 pathway has been previously shown mediate the therapeutic action electroacupucture (EA). Thus, we hypothesized that EA would reduce I/R injury through inhibiting Egr-1 expression via pathway. Mice were pretreated with...
Background: Utilizing high-flow nasal cannula (HFNC) oxygen therapy may prevent the collapse of alveoli and improve overall alveolar ventilation. In this study, we aimed to investigate impact HFNC on postoperative atelectasis in individuals undergoing robotic-assisted laparoscopic surgery. Methods: Patients surgery for rectal cancer were randomly assigned control or groups. After surgical procedure was complete trachea extubated, both groups underwent an initial lung ultrasound (LUS) scan....
Electroacupuncture (EA) has been reported to improve intestinal motility in mice with postoperative ileus (POI). Previous studies, however, have yielded heterogeneous results regarding the effect of EA on POI.
The emergence of myelinating oligodendrocytes represents a pivotal developmental milestone in vertebrates, given their capacity to ensheath axons and facilitate the swift conduction action potentials. It is widely accepted that cortical oligodendrocyte progenitor cells (OPCs) arise from medial ganglionic eminence (MGE), lateral/caudal (LGE/CGE), radial glial (RGCs). Here, we used two different fate mapping strategies challenge established notion LGE generates OPCs. Furthermore,...
Abstract Background Responsiveness of the "jaundiced heart" to propofol is not completely understood. The purpose this study was evaluate effect on myocardial performance in rats with obstructive jaundice. Methods Male Sprague-Dawley (n = 40) were randomly allocated into two groups, twenty underwent bile duct ligation (BDL), and 20 a sham operation. Seven days after surgery, administered vivo ex (Langendorff preparations). Heart rate, left ventricular end-systolic pressure (LVESP)...
Objective The repair of great toe donor site defect after wrap‐around flap transfer is still controversial. bilobed superficial circumflex iliac artery perforator (SCIP) can improve the aesthetics while maintaining its function. Thus, this study aimed to report our experience in reconstruction big defects with SCIP and describe clinical outcomes. Methods This was a retrospective trial. From May 2017 2020, 13 patients were included study. average age 44 years (range, 23–60 years). All...
Abstract Background Cardiac surgery involving cardiopulmonary bypass (CPB) is known to be associated with a transient postoperative immunosuppression. When severe and persistent, this immune dysfunction predisposes patients infectious complications, which contributes prolonged stay in the intensive care unit (ICU), even mortality. Effective prevention treatment methods are still lacking. Recent studies revealed that acupuncture-related techniques, such as electroacupuncture transcutaneous...
Song, J. C.; Sun, Y. M.; Zhang, M. Z.; Yang, L. Q.; Tao, T. A.; Yu, W. F. Author Information
The emergence of myelinating oligodendrocytes represents a pivotal developmental milestone in vertebrates, given their capacity to ensheath axons and facilitate the swift conduction action potentials. It is widely accepted that cortical oligodendrocyte progenitor cells (OPCs) arise from medial ganglionic eminence (MGE), lateral/caudal (LGE/CGE) radial glial (RGCs). Here, we used two different fate mapping strategies challenge established notion LGE generates OPCs. Furthermore, Cre-loxP...
The emergence of myelinating oligodendrocytes represents a pivotal developmental milestone in vertebrates, given their capacity to ensheath axons and facilitate the swift conduction action potentials. It is widely accepted that cortical oligodendrocyte progenitor cells (OPCs) arise from medial ganglionic eminence (MGE), lateral/caudal (LGE/CGE) radial glial (RGCs). Here, we used two different fate mapping strategies challenge established notion LGE generates OPCs. Furthermore,...
The aim of this study is to assess the feasibility and safety monitored anesthesia care (MAC) versus intubated general (IGA) for patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB). This prospective observational included scheduled involving CPB at our institution between April 2012 February 2017. enrolled were categorized into MAC IGA groups. involved local sternotomy site, sedation dexmedetomidine, analgesia remifentanil/sufentanil, electroacupuncture (EA)....