A5075224871- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Adenosine and Purinergic Signaling
- Electrospun Nanofibers in Biomedical Applications
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Tissue Engineering and Regenerative Medicine
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Function and Risk Factors
- Cytokine Signaling Pathways and Interactions
- Metabolism and Genetic Disorders
- Eicosanoids and Hypertension Pharmacology
- Calpain Protease Function and Regulation
- Cancer Cells and Metastasis
- Cardiac Ischemia and Reperfusion
- Ion channel regulation and function
- ATP Synthase and ATPases Research
- Cell Adhesion Molecules Research
- Cardiovascular Issues in Pregnancy
- Bone Tissue Engineering Materials
- RNA Research and Splicing
- Cellular Mechanics and Interactions
- Cancer Research and Treatments
Second Affiliated Hospital of Zhejiang University
2023-2025
Zhejiang University
2023-2024
Blood Center of Zhejiang Province
2024
Sichuan University
2019-2023
West China Hospital of Sichuan University
2019-2023
Jilin University
2018
Cardiac fibrosis is associated with an adverse prognosis in cardiovascular disease, which results a decreased cardiac compliance and ultimately heart failure. Recent studies have identified the role of long non-coding RNA (lncRNA) fibrosis. However, functions many lncRNAs remain to be characterized. Through whole-transcriptome sequencing bioinformatics analysis on mouse model pressure overload-induced fibrosis, we screened key lncRNA termed thrombospondin 1 antisense (THBS1-AS1), was...
P2X7 purinergic receptor (P2X7R) has been implicated in several cardiovascular diseases. However, whether it regulates cardiac fibrosis remains elusive. Herein, its involvement the development of was examined using a transverse aortic constriction (TAC) mice model and fibroblasts (CFs) hyperstimulated by TGF- β 1 for 48 hours. Results showed that TAC treatment increased expression P2X7R. Silencing P2X7R with siP2X7R ameliorated effects on activation. Similarly, inhibition Brilliant Blue G...
Abstract Bioprosthetic heart valves (BHVs) for transcatheter replacement often face deterioration due to thrombosis, inflammation, and calcification, which are irreversible. Here, a multidimensional endothelium‐mimicking healable hydrogel shielded BHV that not only withstand the complex valvular physiological hemodynamic environment but also able reverse damage‐induced structural degeneration by in situ healing is proposed. Polydopamine/selenocystamine nanoparticles with photothermal effect...
Abstract Metal ions participate in many metabolic processes the human body, and their homeostasis is crucial for life. In cardiovascular diseases (CVDs), equilibriums of metal are frequently interrupted, which related to a variety disturbances physiological leading abnormal cardiac functions. Exogenous supplement has potential work as therapeutic strategies treatment CVDs. Compared with other drugs, possess broad availability, good stability safety diverse drug delivery strategies. The...
Cardiac hypertrophy initially serves as an adaptive response to physiological and pathological stimuli. Sustained progress cardiac hypertrophy, fibrosis ultimately lead heart failure, one of the leading medical causes mortality worldwide. Intervention can effectively reduce occurrence failure. Abundant factors, such adrenergic, angiotensin, endothelin (ET-1) receptors, have been shown participate in regulation hypertrophy. Recently, increasing number studies indicated that circRNA...
Cardiac fibrosis is characterized by the excessive deposition of extracellular matrix in myocardium with cardiac fibroblast activation, leading to chronic remodeling and dysfunction. However, little known about metabolic alterations fibroblasts during fibrosis, there a lack pharmaceutical treatments that target dysregulation. Here, we provided evidence fatty acid β-oxidation (FAO) dysregulation contributes activation fibrosis. With transcriptome, metabolome, functional assays, demonstrated...
Myocardial Infarction (MI) is a leading cause of death worldwide. Metabolic modulation promising therapeutic approach to prevent adverse remodeling after MI. However, whether material-derived cues can treat MI through metabolic regulation mainly unexplored. Herein, Cu
Cardiac fibroblasts (CFs) activation is a hallmark feature of cardiac fibrosis caused by remodeling. The purinergic signaling molecules have been proven to participate in the CFs. In this study, we explored expression pattern P2Y receptor family mice model induced transverse aortic constriction (TAC) operation and CFs triggered transforming growth factor β1 (TGF-β1) stimulation. We then investigated role P2Y1receptor (P2Y1R) activated results showed that among members, only P2Y1R was...
Dendritic cell (DC)-based immunotherapy has been a promising strategy for colon cancer therapy, but the efficacy of dendritic vaccines is in part limited by immunogenicity loaded antigens.In this study, we aimed to identify putative tumor antigen that can generate or enhance anti-tumor immune responses against cancer.CD44 + stem cells (CCSCs) were isolated from mouse colorectal carcinoma CT-26 cultures and induced form defective ribosomal products-containing autophagosome-rich blebs...
Oncostatin M (OSM) induces the differentiation of liver cancer stem cells (LCSCs) and increases sensitivity to chemotherapeutic agent 5-fluorouracil, whereas salinomycin (Sal) apoptosis in inhibits proliferation cells. However, there have been no studies investigating anticancer effects combination treatment with OSM Sal. In present study, we investigated synergistic Sal on LCSCs, CD133+ subpopulations from HepG2 human LCSCs were isolated using an immunomagnetic bead technique identified...
The purpose of this study is to investigate the injury liver and kidney tissues in overload pressure induced cardiac hypertrophy/heart failure mice model changes macrophage activation level.6-8 week-old C57BL/6 were subjected transverse aortic constriction (TAC) surgery establish mouse by overload, while was not ligated Sham group. At 4 weeks 8 after TAC, each group echocardiography blood collection. And sacrificed collect samples heart, liver, tissues. contents plasma alanine...