A5043968489- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Polymer Surface Interaction Studies
- Bone Tissue Engineering Materials
- Microfluidic and Bio-sensing Technologies
- Graphene and Nanomaterials Applications
- Cardiac Valve Diseases and Treatments
- Micro and Nano Robotics
- Hydrogels: synthesis, properties, applications
- Nanofabrication and Lithography Techniques
- Cell Adhesion Molecules Research
- Cardiac Fibrosis and Remodeling
- Nerve injury and regeneration
- Neuroscience and Neural Engineering
- Cardiovascular Function and Risk Factors
- Pancreatic function and diabetes
- Advancements in Transdermal Drug Delivery
- Aortic Disease and Treatment Approaches
- Modular Robots and Swarm Intelligence
- Wound Healing and Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Mechanical stress and fatigue analysis
- Surface Modification and Superhydrophobicity
Second Affiliated Hospital of Zhejiang University
2020-2025
Zhejiang University
2012-2024
Blood Center of Zhejiang Province
2024
Stanford University
2020-2022
University of Pittsburgh
2000-2018
McGowan Institute for Regenerative Medicine
2017-2018
Lanzhou University
1992
Abstract Calcific aortic valve disease is a prevalent cardiovascular with no available drugs capable of effectively preventing its progression. Hence, an efficient drug delivery system could serve as valuable tool in screening and potentially enhance therapeutic efficacy. However, due to the rapid blood flow rate associated stenosis lack specific markers, achieving targeted for calcific has proved be challenging. Here we find that protease-activated-receptor 2 (PAR2) expression up-regulated...
Cell migration participates in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation remoulding, tissue regeneration, immune surveillance inflammation. The cells specifically migrate to destiny sites induced by the gradually varying concentration (gradient) soluble signal factors ligands bound with extracellular matrix body during wound healing process. Therefore, regulation cell behaviours is paramount importance...
Post-traumatic massive hemorrhage demands immediately available first-aid supplies with reduced operation time and good surgical compliance. In-situ crosslinking gels that are flexibly adapting to the wound shape have a promising potential, but it is still hard achieve fast gelation, on-demand adhesion, wide feasibility at same time.A white-light crosslinkable natural milk-derived casein hydrogel bioadhesive presented for first time. Benefiting from abundant tyrosine residues, was...
Selective adhesion and migration of endothelial cells (ECs) over smooth muscle (SMCs) is very important in the rapid endothelialization blood-contacting implants to prevent vascular restenosis. In this study, a uniform cell-resistant layer methacrylate-functionalized hyaluronic acid (HA) was first immobilized on poly(ε-caprolactone) (PCL) film via polydopamine coupling. Then, density gradient thiol-functionalized Arg-Glu-Asp-Val (REDV) peptide prepared HA thiol-ene click chemistry continuous...
Diagnostic and therapeutic illumination on internal organs tissues with high controllability adaptability in terms of spectrum, area, depth, intensity remains a major challenge. Here, we present flexible, biodegradable photonic device called iCarP micrometer scale air gap between refractive polyester patch the embedded removable tapered optical fiber. ICarP combines advantages light diffraction by fiber, dual refractions gap, reflection inside to obtain bulb-like illumination, guiding...
Untethered mini-robots can move single cells or aggregates to build complex constructs in confined spaces and may enable various biomedical applications such as regenerative repair medicine biosensing bioengineering. However, a significant challenge is the ability control multiple microrobots simultaneously same space operate toward common goal distributed operation. A locomotion strategy that guide formation operation of robots response acoustic stimulus developed. The scaffold-free...
Abstract Anisotropic 3D tissue interfaces with functional gradients found in nature are replicated vitro for drug development and engineering. Even though different fabrication techniques, based on material science engineering microfluidics, used to generate such microenvironments, mimicking the native gradient is still a challenge. Here, of structures described linear/random porosity distribution hydroxyapatite microparticles which combined growth factors generated by dual chamber...
Directional migration of cells mediated by gradient cues in vitro can mimic the corresponding biological events vivo and thereby provides a way to disclose cascade responses tissue regeneration processes develop novel criteria for design tissue-inductive biomaterials. In this work, molecular weight poly(2-hydroxyethyl methacrylate) (PHEMA) brushes with thickness ranging from 3 30 nm slopes 0.8-3.2 nm/mm were fabricated using surface-initiated atom transfer radical polymerization (ATRP)...
Selective enhancement of directional migration endotheliocytes (ECs) over vascular smooth muscle cells (SMCs) plays a significant role for the fast endothelialization blood-contacting implants, in particular antirestenosis stents. Herein, complementary density gradient poly(2-hydroxyethyl methacrylate) (PHEMA) brushes and YIGSR peptide, sequence specifically improving mobility ECs, was fabricated using dynamically controlled reaction process. The gradients were visualized by fluorescent...
Central nervous system neurons often degenerate after trauma due to the inflammatory innate immune response injury, which can lead neuronal cell death, scarring, and permanently lost neurologic function. Extracellular matrix bioscaffolds, derived by decellularizing healthy tissues, have been widely used in both preclinical clinical studies promote positive tissue remodeling, including neurogenesis, numerous with extracellular from homologous tissues inducing more responses. hydrogels are...
Abstract Heart valves have extraordinary fatigue resistance which beat ≈3 billion times in a lifetime. Bioprosthetic heart (BHVs) made from fixed heteroplasm that are incrementally used valve replacement fail to sustain the expected durability due thrombosis, poor endothelialization, inflammation, calcification, and especially mechanical damage induced biocompatibility change. No effective strategy has been reported conserve biological properties of BHV after long‐term test. Here,...
Tissue engineering raised a high requirement to control cell distribution in defined materials and structures. In "ink"-based bioprintings, such as 3D printing photolithography, cells were associated with inks for spatial orientation; the conditions suitable one ink are hard apply on other inks, which increases obstacle their universalization. The Magneto-Archimedes effect based (Mag-Arch) strategy can modulate locomotion directly without impelling inks. paramagnetic medium, repelled from...
Abstract Bioprosthetic heart valves (BHVs) for transcatheter replacement often face deterioration due to thrombosis, inflammation, and calcification, which are irreversible. Here, a multidimensional endothelium‐mimicking healable hydrogel shielded BHV that not only withstand the complex valvular physiological hemodynamic environment but also able reverse damage‐induced structural degeneration by in situ healing is proposed. Polydopamine/selenocystamine nanoparticles with photothermal effect...
In peripheral nerve (PN) injuries requiring surgical repair, as in PN transection, cellular and ECM remodeling at epineurial repair sites is hypothesized to reduce functional outcomes by slowing, misdirecting, or preventing axons from regrowing appropriately across the site. Herein this study reports on deriving analyzing fetal porcine urinary bladder extracellular matrix (fUB-ECM) vacuum assisted decellularization, fabricating fUBM-ECM wraps, testing fUB-ECM wrap biocompatibility...
Abstract Metal ions participate in many metabolic processes the human body, and their homeostasis is crucial for life. In cardiovascular diseases (CVDs), equilibriums of metal are frequently interrupted, which related to a variety disturbances physiological leading abnormal cardiac functions. Exogenous supplement has potential work as therapeutic strategies treatment CVDs. Compared with other drugs, possess broad availability, good stability safety diverse drug delivery strategies. The...
The surface-grafted poly(hydroxylethyl methacrylate) (PHEMA) molecules were demonstrated to show a brush state regardless of their molecular length (molecular weight). Adsorption proteins from 10% fetal bovine serum (FBS), fibronectin (Fn) and albumin (BSA) was quantified by ellipsometry, revealing that the amounts FBS Fn decreased monotonously along with increase PHEMA thickness, whereas not detectable for BSA when thickness larger than 6 nm. Radio immunoassay found adsorption had no...