A5102947632- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Sarcoma Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Occupational and environmental lung diseases
- Congenital Diaphragmatic Hernia Studies
- Peptidase Inhibition and Analysis
- Occupational exposure and asthma
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- Kruppel-like factors research
- Fungal Infections and Studies
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Cancer-related gene regulation
- Protein Tyrosine Phosphatases
Tongji University
2015-2025
Tongji Hospital
2015-2025
Shanghai Pulmonary Hospital
2002-2017
X-Fab (Germany)
2017
Chongqing Medical University
2017
Guangzhou University
2009
Yahoo (United Kingdom)
2008
Army Medical University
2007
Xinqiao Hospital
2007
High salt is positively associated with the risk of many diseases. However, little known about mechanisms. Here we showed that high increased proinflammatory molecules, while decreased anti-inflammatory and proendocytic molecules in both human mouse macrophages. also potentiated lipopolysaccharide-induced macrophage activation suppressed interleukin 4-induced activation. induced aspects by activating p38/cFos and/or Erk1/2/cFos pathways, inhibited Erk1/2/signal transducer activator...
The definition of tumour deposit (TD) in colorectal cancer (CRC) was changed recently the American Joint Commission on Cancer (AJCC) Staging Manual, 7th edition. We aimed to examine prognostic values newly defined TD and perineural invasion (PNI) this population study.We identified incidental CRC cases with known or PNI status Surveillance, Epidemiology, End Results (SEER) programme diagnosed 2010 2011. Kaplan-Meier survival analysis multivariable Cox proportional hazards models were used...
Abstract Purpose: Despite the challenge to directly target mutant KRAS due its high GTP affinity, some agents are under development against downstream signaling pathways, such as MEK inhibitors. However, it remains controversial whether inhibitors can boost current chemotherapy in KRAS-mutant lung tumors clinic. Considering genomic heterogeneity among patients with cancer, is valuable test potential therapeutics mutation–driven mouse models. Experimental Design: We first compared pERK1/2...
Latest study showed that a novel translocation between programmed cell death ligand 1 (PD-L1) (cluster of differentiation 274) and TP63 (tumor protein 63) can be found in diffuse large B-cell lymphoma (DLBCL), resulting their conjunct overexpression tumor cells at RNA level. However, the expressed pattern these 2 genes level DLBCL remains largely unknown, clinical relevance PD-L1 expression are also unclear. Tumor tissues from 76 Chinese patients were immunostained for (PD-1), PD-L1, using...
Abstract Patients with pulmonary fibrosis often have low vitamin D levels, the effects of which are largely unknown. We here report that early supplementation significantly reduced severity and inflammatory cell accumulationin in bleomycin-induced mouse model on supplementary days 14, 21 28 ( P < 0.001). Vitamin also prevented some ultrastructural changes response to bleomycin administration, including basement membrane thickening, interstitial fibrin deposition microvilli flattening or...
Background Patients with diffuse panbronchiolitis (DPB) are routinely treated erythromycin, clarithromycin, and roxithromycin. The clinical effect of azithromycin on DPB has not been confirmed in a large cohort. Objective present study was undertaken to investigate the effects patients DPB. Methods Fifty-one Shanghai Pulmonary Hospital, China, from July 2001 April 2007 were analyzed retrospectively. Azithromycin (500 mg day) administrated intravenously first 1-2 weeks, taken orally mg, once...
Abstract Recent studies have linked appearance of Paneth cells in colorectal adenomas to adenoma burden and male gender. However, the clinical importance cells’ associations with synchronous advanced (AA) carcinoma (CRC) is currently unclear. We performed a comprehensive case-control study using 1,900 including 785 from females 1,115 males. prospectively reviewed recorded cell status consecutively collected between February 2014 June 2015. Multivariable logistic regression analyses revealed...
Emerging molecular diagnostic methods are more sensitive and objective, which can overcome the intrinsic failings of morphological diagnosis. Here, a RT-PCR-based in vitro test kit (LungMe ® ) was developed characterized to simultaneously quantify DNA methylation SHOX2 RASSF1A FFPE tissue specimens. The clinical manifestations were evaluated 251 samples with specificity sensitivity 90.4 89.8%, respectively. Furthermore, quantitative analysis shows that degree correlated stages lung cancer,...
Objective: The aim of this study was to investigate the inhibitory effect dexamethasone on state proliferation/apoptosis pulmonary inflammatory cells in a rat fibrosis model induced by bleomycin. Methodology: Seventy‐five pathogen‐free Sprague‐Dawley (SD) rats were randomly divided into three groups: control, bleomycin (BLM) and (DXM) groups with 25 each group. Each group then five subgroups based time (1‐, 3‐, 7‐, 14‐ 28‐days). BAL fluid obtained, counted differential performed. A lower DNA...
Prostate cancer (PCa) has become a prevalent malignant disease in males globally. Accumulating data suggested that hsa-microRNAs (miRNAs) could be potential biomarkers for tumor diagnosis due to their important roles the cell cycle. This study investigated diagnostic and prognostic values of hsa-miR-203 hsa-miR-30c PCa tissues. There were 44 pathologically confirmed patients who enrolled this study. Tissue samples collected from both tissues adjacent normal RNA was extracted expression...
Objective: To clarify the clinicopathologic and ultrastructural features of primary pulmonary cryptococcosis (PC).Methods: 43 cases PC were observed by light microscopy histochemical staining, including mucicarmine (MC), Alcian blue (AB), periodic acid–Schiff (PAS), Grocott methenamine–silver (GMS). Transmission electron (TEM) was performed on 11 fresh 8 formalin-fixed specimens.Results: The detective rate Cryptococcus neoformans (CN) MC, AB, PAS, GMS TEM 61.3% (19/31), 62.2% (23/37), 85.7%...
Idiopathic pulmonary fibrosis (IPF) and idiopathic nonspecific interstitial pneumonia (INSIP) are two related diseases involving varying degrees of with no effective cure. Bone morphogenetic protein 3 (BMP3) is a member the transforming growth factor-β (TGF-β) super-family, which has not been implicated in previously. In this study, we aimed to investigate potential role BMP3 playing from clinical diagnosis molecular signaling regulation. RNA sequencing was performed explore biomarker IIP...