A5075345429- COVID-19 Impact on Reproduction
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Maternal Mental Health During Pregnancy and Postpartum
- Ovarian function and disorders
- Infant Health and Development
- Cardiovascular Issues in Pregnancy
- Endometriosis Research and Treatment
- Breastfeeding Practices and Influences
- Neuroscience of respiration and sleep
- Health and Medical Studies
- Uterine Myomas and Treatments
- Immune Response and Inflammation
- Neonatal and Maternal Infections
- Congenital Diaphragmatic Hernia Studies
- Esophageal and GI Pathology
- Neuroendocrine regulation and behavior
- Obesity, Physical Activity, Diet
- Gynecological conditions and treatments
- Cancer Risks and Factors
Klinik für Frauenheilkunde
2015-2024
University of Regensburg
2015-2024
University Hospital Regensburg
2015-2022
Krankenhaus Barmherzige Brüder
2017-2022
St. Hedwig-Krankenhaus
2019-2021
GTx (United States)
2017
Institut für Frauengesundheit
2017
Otto-von-Guericke University Magdeburg
2007-2014
Yale University
2009
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2009
Abstract Regulatory T cells (Treg) expand during pregnancy and are present at the fetal-maternal interface very early stages in pregnancy. The migration mechanisms of Treg to pregnant uterus still unclear. Human chorionic gonadotropin (hCG) is secreted by blastocyst immediately after fertilization has chemoattractant properties. Therefore, we sought analyze whether hCG trophoblasts attracts hence contributes maternal tolerance toward fetus. Decidua placenta tissue samples from patients...
Problem Toll‐like receptors (TLRs) recognize conserved sequences on the surface of pathogens and trigger effector cell functions. Previously, we described expression TLR3 by human trophoblast their ability to respond (Poly[I:C]). Here evaluate effect Poly[I:C] mouse pregnancy characterize local systemic response. Method study C57B/6 wild type (wt) knockout (TLR3KO) mice were treated with at 16.5 dpc outcome recorded. Morphologic changes, cytokines chemokines levels in blood utero‐placental...
Background Mast cells (MCs) have long been suspected as important players for implantation based on the fact that their degranulation causes release of pivotal factors, e.g., histamine, MMPs, tryptase and VEGF, which are known to be involved in attachment posterior invasion embryo into uterus. Moreover, MC correlates with angiogenesis during pregnancy. The number MCs uterus has shown fluctuate menstrual cycle human estrus rat mouse indicating a hormonal influence recruitment from periphery...
A COVID-19 vaccine can be an important key for mitigating the spread of pandemic, provided that it is accepted by a sufficient proportion population. This study investigated parents' intention to get vaccinated and have one's child against COVID-19. In May 2020, 612 parents participating with their in KUNO-Kids health completed online survey. Multivariable logistic regression models were calculated analyze predictors vaccinate. Fifty-eight percent intended COVID-19, 51% vaccinated....
(1) Background: Data on coronavirus 2 infection during pregnancy vary. We aimed to describe maternal characteristics and clinical presentation of SARS-CoV-2 positive women requiring intensive care treatment for COVID-19 postpartum period based data a comprehensive German surveillance system in obstetric patients. (2) Methods: from Related Obstetric Neonatal Outcome Study (CRONOS), prospective multicenter registry pregnant women, was analyzed with respect ICU treatment. All were included...
Symptoms of gastro-esophageal reflux disease (GERD) in pregnancy are reported with a prevalence 30-80%. The aim this study was to assess the and severity GERD symptoms during course pregnancy. Furthermore current practice medical care for assessed.We performed prospective longitudinal cohort on 510 pregnant women (mean age 28.12, SD 5.3). Investigations where based use validated reflux-disease questionnaire (RDQ). Additional information collected about therapy. A group non-pregnant 24.56,...
Introduction Extracorporeal Membrane Oxygenation (ECMO) may be used in the setting of pregnancy or peripartal period, however its utility has not been well-characterized. This study aims to give an overview on prevalence peripartel ECMO cases and further assess indications outcomes this across multiple centers countries. Methods A retrospective, multicenter, international cohort pregnant peripartum was performed. Data were collected from six three continents over a 10-year period. Results...
Problem Survivin, a tumor‐promoting antiapoptotic molecule, is expressed in the human placenta. Here, we analyzed its expression during normal and pathological murine pregnancy investigated participation first trimester trophoblast cell survival proliferation. Method of study We survivin on mRNA protein level at fetal–maternal interface pregnant (CBA/J × BALB/c) abortion‐prone DBA/2J) mice different stages by RT‐PCR immunohistochemistry. also evaluated apoptosis trophoblasts both mating...
Heartburn is known to be common during pregnancy, however validated data on gastroesophageal reflux disease (GERD) are missing. The aim of this survey was study the prevalence GERD, frequency and severity typical GERD symptoms, their impact quality life therapeutic management in advanced pregnancy.One hundred thirty-five consecutive pregnant women third trimester were included a prospective using questionnaires: RDQ, QOLRAD self-administered questionnaire detailing sociodemographic...
Problem Thrombophilia is associated with pregnancy complications. Treatment low molecular weight heparin ( LMWH ) improves outcome, but the underlying mechanisms are not clear. Methods of study We analyzed T reg frequency in blood from thrombophilic pregnancies treated n = 32) or untreated 33) and healthy 39) at all trimesters. Additionally, we pregnant wild‐type, heterozygous homozygous factor‐ V ‐ L eiden FVL mice PBS determined frequency, pro‐/anti‐inflammatory cytokine levels C...
Typical symptoms of gastroesophageal reflux disease (GERD) are known to be frequent in pregnancy. The aim this study was gain a first estimation the occurrence extraesophageal context.A prospective longitudinal performed on 166 pregnant women and control group 285 women. diagnosis GERD based Montreal classification using questionnaire (RDQ). Extraesophageal were recorded with self-administered questionnaire. each trimester pregnancy.The prevalence during pregnancy 16.9% first, 25.3% second...
Abstract Objectives In the current Severe Acute Respiratory Distress Coronavirus 2 (SARS-CoV-2) pandemic there is still great uncertainty about effects of an infection in pregnancy especially regarding a possible fetal transmission antibodies to SARS-CoV-2 and longevity this immunity. Methods Sixteen women who were infected with during their offspring included. The antibody response was measured mother umbilical cord blood peripartum follow-up examination 6–11 weeks after birth. Medical...
Abstract Purpose Despite the health benefits of full breastfeeding for both infants and mothers, less than 50% mothers in Germany practice this method at least 4 months after childbirth. Because growing importance literacy to improve public health, we investigated role maternal behavior. Methods We analyzed data 1172 mother–child dyads KUNO-Kids study University Children’s Maternity Hospital Regensburg. Maternal was assessed with HLS-EU-Q47 questionnaire (sub-index care) up 48 h Outcome 6...
Sister Mary Joseph's nodule is an inconspicuous and uncommon clinical sign of advanced malignant disease, especially gastric cancer.Pregnancy-associated cancer extremely rare condition can be difficult to diagnose, due the absence or misinterpretation symptoms as pregnancy-related.Diagnostic aids, such a basic chemistry panel imaging techniques, may not show any abnormalities.We present case 37-yearold pregnant patient whose umbilical was first presenting physical cancer, which had...
Objective Pregnant women often suffer from gastroesophageal reflux disease (GERD). GERD symptoms are known to influence the quality of life; however, there is a lack data in pregnant women. The aim this study was establish impact on health-related life (HRQOL) during pregnancy. Participants and methods A prospective longitudinal cohort investigate HRQOL carried out 510 330 nonpregnant as controls. Two validated questionnaires, Reflux Disease Questionnaire Quality Life Dyspepsia...
Several studies show that donor red blood cells (RBCs) can be processed by gravity separation with a hollow-fiber filtration system. This study investigated whether fetal could filtered in the same way.Twelve newborns born after healthy pregnancies were included study. Placental was sampled standard procedures. The separated specially designed system (Sangofer neonatal, Heim Group). RBC bag contained 10 mL of saline, adenine, glucose-mannitol (SAG-M) for stabilization. After processing,...
Problem The immune modulatory effect of heme oxygenase‐1 ( HO ‐1) is well documented in studies about sepsis and transplantation. This work evaluates the influence ‐1 on innate response during pregnancy. Method Study Human first‐trimester trophoblasts derived from normal pregnancies or spontaneous abortions were analyzed for their basal ‐1, BCL ‐associated athanogene‐1 (Bag‐1), cytokine production before after LPS treatment. In vivo , pregnant Hmox1 +/+ +/− female mice treated with Bag‐1 was...
Abstract Background The aim of this study was to examine the interaction a multitude socio-economic, lifestyle, environmental, psychosocial and birth related determinants their effect on maternal health four weeks after delivery. Methods We used data from German cohort study, KUNO-Kids study. Social determinants, as well self-rated physical mental status mothers (indicated by means SF-12-questionnaire) were assessed through standardized questionnaires personal interviews right delivery...
Background: The SARS-CoV-2 pandemic and its influence on peripartum processes worldwide led to issues in breastfeeding support. Research Aim: aim of this study was describe behavior in-hospital management during the Germany Austria. Methods: This a descriptive using combination secondary longitudinal data cross-sectional online survey. Registry from prospective multicenter COVID-19 Related Obstetric Neonatal Outcome Study (CRONOS) cohort (longitudinal, medical records 1,815 parent-neonate...
We report on a 27‐year‐old primipara suffering from pre‐eclampsia who died within 2 days postpartum. Toxemia with disseminated intravascular coagulation (DIC) and acute renal failure had masked the symptoms of invasive candida esophagitis candidiasis in both lungs. Candida sepsis was discovered as cause death at postmortem examination. Myeloperoxidase (MPO) deficiency identified having supported infection. conclude that combination MPO‐deficiency gestational toxemia may indicate increased...
Problem Neonatal sepsis is a serious threat especially for preterm infants. As existing in vitro and vivo models have limitations, we generated novel neonatal model using humanized mice tested the effect of Betamethasone Indomethacin which are used clinic case premature birth. Method study Humanized were infected with Escherichia coli (E. coli) . Subsequently, infection itself, treatment on survival, recovery, bacterial burden, leukocyte populations, cytokine production, was analyzed....