A5038274554- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Liver physiology and pathology
- Gallbladder and Bile Duct Disorders
- Metabolism and Genetic Disorders
- Clinical Nutrition and Gastroenterology
- Drug Transport and Resistance Mechanisms
- Transplantation: Methods and Outcomes
- Liver Diseases and Immunity
- Child and Adolescent Health
- Health and Medical Studies
- Congenital Anomalies and Fetal Surgery
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Organometallic Complex Synthesis and Catalysis
- Intestinal Malrotation and Obstruction Disorders
- Birth, Development, and Health
- Childhood Cancer Survivors' Quality of Life
- Asthma and respiratory diseases
- Endoplasmic Reticulum Stress and Disease
- Inflammatory Bowel Disease
- Breastfeeding Practices and Influences
University Hospital Regensburg
2016-2025
University of Regensburg
2015-2024
Kinderklinik Regensburg
2008-2024
Klinik und Poliklinik für Kinder- und Jugendmedizin
2013-2024
Krankenhaus Barmherzige Brüder
2011-2022
St. Hedwig-Krankenhaus
2011-2022
Uniwersytecki Szpital Dziecięcy
2018-2020
Children's Clinical University Hospital
2020
National Defense Medical College
2011
Medizinische Hochschule Hannover
1998-2009
Because of its availability, ease collection, and correlation with physiology pathology, urine is an attractive source for clinical proteomics/peptidomics. However, the lack comparable data sets from large cohorts has greatly hindered development proteomics. Here, we report establishment a reproducible, high resolution method peptidome analysis naturally occurring human urinary peptides proteins, ranging 800 to 17,000 Da, using samples 3,600 individuals analyzed by capillary electrophoresis...
Background Chemokines play an essential role in regulating the infiltration of leukocytes into allografts experimental models. Little is known their expression or function after human cardiac transplantation. Methods and Results We analyzed 169 sequential endomyocardial biopsies by immunocytochemistry for CD3 + T cells chemokine receptors CCR1, CCR3, CCR5, CXCR3. In both cross-sectional longitudinal analyses, each correlated with degree T-cell infiltration. particular, CXCR3 was temporally...
A COVID-19 vaccine can be an important key for mitigating the spread of pandemic, provided that it is accepted by a sufficient proportion population. This study investigated parents' intention to get vaccinated and have one's child against COVID-19. In May 2020, 612 parents participating with their in KUNO-Kids health completed online survey. Multivariable logistic regression models were calculated analyze predictors vaccinate. Fifty-eight percent intended COVID-19, 51% vaccinated....
Liver transplantation is the final therapeutic option for about 10% of patients with autoimmune hepatitis (AIH) who do not respond to medical therapy. The aim this study was evaluate long-term outcome in serologically defined subgroups AIH after transplantation.Pre- and post-transplantation data 28 transplanted between 1987 1999 were retrospectively analyzed compared 24 patients, underwent liver because Wilson's disease glycogen storage type 1.Serological analyses identified 1 (n = 13), 2...
Purpose To identify prognostic factors of survival in pediatric post-transplantation lymphoproliferative disorder (PTLD) after solid organ transplantation. Patients and Methods A multicenter, retrospective case analysis 55 graft recipients (kidney, liver, heart/lung) developing PTLD were reported to the German Pediatric-PTLD registry. Patient charts analyzed for tumor characteristics (histology, immunophenotypes, cytogenetics, Epstein-Barr virus [EBV] detection), stage, treatment, outcome....
Abstract Liver regeneration can be impaired by permanent oxidative stress and activation of nuclear factor erythroid 2-related 2 (Nrf2), known to regulate the cellular antioxidant response, has been shown improve process liver regeneration. A variety factors hepatic tissue regeneration, among them augmenter (ALR), attained great attention as being survival for with proproliferative antiapoptotic properties. Here we determined Nrf2/ response element (ARE) regulated expression ALR show a...
Adenoviral (AdV) infections after transplantation remain a challenge in pediatric patients. Qualitative and quantitative PCR offer new approaches to early diagnosis monitoring. However, their role the management of AdV transplant recipients remains be determined. We report six children with positive qualitative serum-PCR for on routine follow-up (liver n = 4, hematopoetic stem cells (HSCT) 1, combined liver HSCT 1). None these were symptomatic at time first detection AdV. Two patients...
Birth cohort studies can contribute substantially to the understanding of health and disease — in childhood over life course. The KUNO-Kids birth study was established investigate various aspects child health, using novel omics technologies a systems medicine approach. After 3 years recruitment, 2515 infants their families have joined study. Parents with higher education are overrepresented as many other cohorts more likely complete follow-up assessments via self-report questionnaires. vast...
Progressive familial intrahepatic cholestasis (PFIC) usually presents with pruritus, jaundice, hepatomegaly, and growth failure. A group of PFIC is recognized by marked elevation total serum bile acids, decreased apolipoprotein A-1, high-density lipoprotein, but normal gamma-glutamyltranspeptidase cholesterol. Although medical therapy generally fails, partial external biliary diversion (DIV) has been used promising results for cholestasis. However, little reported its effect on linear...
Patients with Wilson's disease (WD), Indian childhood cirrhosis (ICC), and idiopathic copper toxicosis (ICT) develop severe liver morphologically characterized by ballooning of hepatocytes, inflammation, cytoskeletal alterations, Mallory body (MB) formation, finally leading to mostly micronodular cirrhosis. The pathogenesis MBs in is still unresolved. Immunohistochemical analysis different types intoxication revealed that keratin, p62, ubiquitin are integral components. Thus associated...
Biliary atresia (BA) is the leading indication for liver transplantation (LTx) during childhood. Predictive markers progression are lacking. We investigated correlation between quantified fibrosis of at time Kasai hepatic portoenterostomy (KPE) and clinical course. Liver tissue was obtained KPE in 53 children stained with Picrosirius red. The mean volume per number periportal fields (Vfib) Ishak score were calculated. Vfib 3.9%. Transplant-free survival significantly higher those patients <...
OBJECTIVE Postoperative adjuvant steroid treatment is reported to improve jaundice-free survival in biliary atresia (BA) patients and reduce the need for early liver transplantation. However, evidence of all retrospective studies very limited, although high-dose corticosteroids were favored. The aim this dosage finding study was test most promising corticosteroid protocol a smaller but representative series, order optimize settings upcoming prospective long-term multicenter studies. METHODS...
Four loop-mutants of the blue copper protein amicyanin from Paracoccus versutus have been constructed and characterized. The mutations replaced loop containing three (Cys93, His96, Met99) four ligands in by "ligand loops" P. aeruginosa azurin (AmiAzu), A. faecalis pseudoazurin (AmiPaz), nigra plastocyanin (AmiPcy), aureofaciens nitrite reductase (AmiNiR). centers all variants appear to be perfect type-1 Cu sites although AmiNiR variant exhibits diminished stability. optical spectra AmiAzu...
Current management of extrahepatic portal vein thrombosis (EPVT) comprises endoscopic eradication therapy esophageal varices and conventional shunt surgery. The authors have used the novel technique mesenterico-left bypass (Rex shunt) in seven children with symptomatic EPVT, report their results here.Median age was 12 years (range, 2-16 years). All had hypertension hypersplenism recurrent bleeding from varices. Furthermore, one patient suffered a severe hepatopulmonary syndrome. Preoperative...
ABSTRACT Background The development of graft fibrosis after pediatric liver transplantation (PLT) remains a major concern as it can lead to failure and ultimately loss. Elastography is non‐invasive method assess fibrosis, but its role in the posttransplant setting unclear. aim our study was evaluate shear wave elastography (SWE) assessment PLT, including split‐liver recipients. Methods We retrospectively analyzed data from PLT recipients who underwent surveillance biopsy concurrent 2D‐SWE...
Ligation of endothelial cell (EC) CD40 induces the expression several proinflammatory cytokines as well angiogenesis factors, including vascular growth factor (VEGF). Moreover, despite reported importance in cell-mediated immunity, little is known CD40-induced signaling pathways EC. In this study, we have investigated function Ras pathway(s) for overexpression VEGF. EC were transiently transfected with a full-length VEGF promoter-luciferase construct and dominant-inhibitory mutant (Ras17N)....
Biliary atresia (BA) is a rare but potentially devastating disease. The European Atresia Registry (EBAR) was set up to improve data collection and develop pan-national interdisciplinary strategy clinical outcomes. From 2001 2005, 100 centers from 22 countries registered with EBAR via its website (www.biliary-atresia.com). In June 2006, the first meeting held evaluate results launch further initiatives. During 5-year period, 60 19 Israel sent completed registration forms for total of 514 BA...